NCCN Guidelines for prostate cancer initial risk stratification
NCCN guidelines revise frequently. Suggest checking the latest version.
(Screen capture from version 3.2022 — January 10, 2022, page PROS-2)
D'Amico risk classification for localized disease
Clinical stages T3a, T3b, and T4 are not considered here.
PRECISE scores for active surveillance
Prostate Cancer Radiological Estimation of Change in Sequential Evaluation (PRECISE)
PRECISE scores (1-5) definition:
Resolution of previous features suspicious on MRI
Reduction in volume and/or conspicuity of previous features suspicious on MRI
Stable MRI appearance: no new focal/diffuse lesions
Significant increase in size and/or conspicuity of features suspicious for prostate cancer
Definitive radiologic stage progression
PRECISE scores example:
Previously enhancing area no longer enhances
Reduction in size of previously seen lesion that remains suspicious for clinically significant disease
Either no suspicious features or all lesions stable in size and appearance
Lesion becomes visible on diffusion-weighted imaging; significant increase in size of previously seen lesion
Appearance of extracapsular extension, seminal vesicle involvement, lymph node involvement, or bone metastasis