・Takashi Horie, Wataru Takagi, Naotaka Aburatani, Manabu Yamazaki, Mayu Inokuchi, Masaya Tachizawa, Kataaki Okubo, Ritsuko Ohtani-Kaneko, Kotaro Tokunaga, Marty Kwok-Sing Wong, Susumu Hyodo  

"Segment-Dependent Gene Expression Profiling of the Cartilaginous Fish Nephron Using Laser Microdissection for Functional Characterization of Nephron at Segment Levels."

Zoolog Sci.  2023 Apr;40(2):91-104. doi: 10.2108/zs220092. PMID: 37042689 

・Shiono S, Tsutiya A, Ohtani-Kaneko R. 

"Early Detection of Male-Predominant Phenotypes in the Pattern of Ultrasonic Vocalizations Emitted by Autism Spectrum Disorder Model ( Crmp4-Knockout) Mice."

Brain Sciences. Brain Sci. 2022 May 20;12(5):666. doi: 10.3390/brainsci12050666. PMID: 35625052 

・Oda A, Inoue S, Kaneko R, Narita Y, Shiono S, Kaneko T, Tseng YC, Ohtani-Kaneko R. 

"Involvement of IGF-1R-PI3K-AKT-mTOR pathway in increased number of GnRH3 neurons during androgen-induced sex reversal of the brain in female tilapia."

Sci Rep. 2022 Feb 14;12(1):2450. doi: 10.1038/s41598-022-06384-4. PMID: 35165334

・Ohtani-Kaneko R. 

"Crmp4-KO Mice as an Animal Model for Investigating Certain Phenotypes of Autism Spectrum Disorders."

 Int J Mol Sci. 2019 May 20;20(10):2485. doi: 10.3390/ijms20102485. PMID: 31137494

・Narita Y, Tsutiya A, Nakano Y, Ashitomi M, Sato K, Hosono K, Kaneko T, Chen RD, Lee JR, Tseng YC, Hwang PP, Ohtani-Kaneko R.
"Androgen induced cellular proliferation, neurogenesis, and generation of GnRH3 neurons in the brain of mature female Mozambique tilapia."
Sci Rep 2018 Nov 15;8(1):16855. doi: 10.1038/s41598-018-35303-9. PMID: 30442908

・Iketani M, Sekimoto K, Igarashi T, Takahashi M, Komatsu M, Sakane I, Takahashi H, Kawaguchi H, Ohtani-Kaneko R, Ohsawa I.
"Administration of hydrogen-rich water prevents vascular aging of the aorta in LDL receptor-deficient mice."
Sci Rep 2018 Nov 14;8(1):16822. doi: 10.1038/s41598-018-35239-0. PMID: 30429524

・Tsutiya A, Nakano Y, Hansen-Kiss E, Kelly B, Nishihara M, Goshima Y, Corsmeier D, White P, Herman GE, Ohtani-Kaneko R.
"Human CRMP4 mutation and disrupted Crmp4 expression in mice are associated with ASD characteristics and sexual dimorphism."
Sci Rep 2017 7: 16812–16825.

・Ohtani-Kaneko R, Sato K, Tsutiya A, Nakagawa Y, Hashizume K, Tazawa H.
"Characterisation of human induced pluripotent stem cell-derived endothelial cells under shear stress using an easy-to-use microfluidic cell culture system."
Biomed Microdevices 2017 19: 91.

・Tazawa H, Sunaoshi S, Tokeshi M, Kitamori T, Ohtani-Kaneko R.
"An Easy-to-Use Polystyrene Microchip-based Cell Culture System."
Anal Sci 2016 32: 349–353.

・Tsutiya A, Watanabe H, Nakano Y, Nishihara M, Goshima Y, Ohtani-Kaneko R.
"Deletion of collapsin response mediator protein 4 results in abnormal layer thickness and elongation of mitral cell apical dendrites in the neonatal olfactory bulb."
J Anat 2016 228: 792–804.

・Tsutiya A, Nishihara M, Goshima Y, Ohtani-Kaneko R.
"Mouse pups lacking collapsin response mediator protein 4 manifest impaired olfactory function and hyperactivity in the olfactory bulb."
Eur J Neurosci 2015 42: 2335–2345.

・Tazawa H, Sato K, Tsutiya A, Tokeshi M, Ohtani-Kaneko R.
"A microfluidic cell culture system for monitoring of sequential changes in endothelial cells after heat stress."
Thromb Res 2015 136: 328–334.

・Sato K, Yamanaka Y, Ishii M, Ishibashi K, Ogura Y, Ohtani-Kaneko R, Nishihara M, Nedachi T.
"Dual cell protective mechanisms activated by differing levels of oxidative stress in HT22 murine hippocampal cells."
Biosci Biotechnol Biochem 2014 78: 1495–1503.

・Iwakura T, Sakoh M, Tsutiya A, Yamashita N, Ohtani A, Tsuda MC, Ogawa S, Tsukahara S, Nishihara M, Shiga T, Goshima Y, Kato T, Ohtani-Kaneko R.
"Collapsin response mediator protein 4 affects the number of tyrosine hydroxylase-immunoreactive neurons in the sexually dimorphic nucleus in female mice."
Dev Neurobiol 2013 73: 502–517.

・Tsutiya A, Ohtani-Kaneko R.
"Postnatal alteration of collapsin response mediator protein 4 mRNA expression in the mouse brain."
J Anat 2012 221: 341–351.

・Koseki N, Kitaoka Y, Munemasa Y, Kumai T, Kojima K, Ueno S, Ohtani-Kaneko R.
"17β-estradiol prevents reduction of retinal phosphorylated 14-3-3 zeta protein levels following a neurotoxic insult."
Brain Res 2012 1433: 145–152.

・Kuramochi A, Tsutiya A, Kaneko T, Ohtani-Kaneko R.
"Sexual dimorphism of gonadotropin-releasing hormone type-III (GnRH3) neurons and hormonal sex reversal of male reproductive behavior in Mozambique tilapia."
Zoolog Sci 2011 28: 733–739.

・Wu Y, Moriya-Ito K, Iwakura T, Tsutiya A, Ichikawa M, Ohtani-Kaneko R.
"Sexually dimorphic effects of estrogen on spines in cultures of accessory olfactory bulb."
Neurosci Lett 2011 500: 77–81.

・Ooka S, Nakano H, Matsuda T, Okamoto K, Suematsu N, Kurokawa MS, Ohtani-Kaneko R, Masuko K, Ozaki S, Kato T.
"Proteomic surveillance of autoantigens in patients with Behcet's disease by a proteomic approach."
Microbiol Immunol 2010 54: 354–361.

・Iwakura T, Iwafuchi M, Muraoka D, Yokosuka M, Shiga T, Watanabe C, Ohtani-Kaneko R.
"In vitro effects of bisphenol A on developing hypothalamic neurons."
Toxicology 2010 272: 52–58.

・Ohtani-Kaneko R, Iwafuchi M, Iwakura T, Muraoka D, Yokosuka M, Shiga T, Watanabe C.
"Effects of estrogen on synapsin I distribution in developing hypothalamic neurons."
Neurosci Res 2010 66: 180–188.

・Ohtani-Kaneko R, Tazawa H, Yokosuka M, Yoshida M, Satoh M, Watanabe C.
"Suppressive effects of cadmium on neurons and affected proteins in cultured developing cortical cells."
Toxicology 2008 253: 110–116.

・Munemasa Y, Kitaoka Y, Hayashi Y, Takeda H, Fujino H, Ohtani-Kaneko R, Hirata K, Ueno S.
"Effects of unoprostone on phosphorylated extracellular signal-regulated kinase expression in endothelin-1-induced retinal and optic nerve damage."
Vis Neurosci 2008 25: 197–208.

・Fujisawa H, Ohtani-Kaneko R, Naiki M, Okada T, Masuko K, Yudoh K, Suematsu N, Okamoto K, Nishioka K, Kato T.
"Involvement of post-translational modification of neuronal plasticity-related proteins in hyperalgesia revealed by a proteomic analysis."
Proteomics 2008 8: 1706–1719.

・Yokosuka M, Ohtani-Kaneko R, Yamashita K, Muraoka D, Kuroda Y, Watanabe C.
"Estrogen and environmental estrogenic chemicals exert developmental effects on rat hypothalamic neurons and glias."
Toxicol In Vitro 2008 22: 1–9.

・Kato T, Ohtani-Kaneko R, Shiga T.
"Dorsal root ganglion regulates the transient ERK activation in the dorsal horn of the spinal cord during development."
Neurosci Res 2007 58: 402–405.

・Hayashi Y, Kitaoka Y, Munemasa Y, Ohtani-Kaneko R, Kikusui T, Uematsu A, Takeda H, Hirata K, Mori Y, Ueno S.
"Neuroprotective effect of 17beta-estradiol against N-methyl-D-aspartate-induced retinal neurotoxicity via p-ERK induction."
J Neurosci Res 2007 85: 386–394.

・Kamijo-Ikemori A, Sugaya T, Obama A, Hiroi J, Miura H, Watanabe M, Kumai T, Ohtani-Kaneko R, Hirata K, Kimura K.
"Liver-type fatty acid-binding protein attenuates renal injury induced by unilateral ureteral obstruction."
Am J Pathol 2006 169: 1107–1117.

・Munemasa Y, Ohtani-Kaneko R, Kitaoka Y, Kumai T, Kitaoka Y, Hayashi Y, Watanabe M, Takeda H, Hirata K, Ueno S.
"Pro-apoptotic role of c-Jun in NMDA-induced neurotoxicity in the rat retina."
J Neurosci Res 2006 83: 907–918.

・Ohtani-Kaneko R.
"Mechanisms underlying estrogen-induced sexual differentiation in the hypothalamus."
Histol Histopathol 2006 21: 317–324. Review.

・Hiroi J, Miyazaki H, Katoh F, Ohtani-Kaneko R, Kaneko T.
"Chloride turnover and ion-transporting activities of yolk-sac preparations (yolk balls) separated from Mozambique tilapia embryos and incubated in freshwater and seawater."
J Exp Biol 2005 208: 3851–3858.

・Igarashi-Migitaka J, Takeshita A, Koibuchi N, Yamada S, Ohtani-Kaneko R, Hirata K.
"Differential expression of p160 steroid receptor coactivators in the rat testis and epididymis."
Eur J Endocrinol 2005 153: 595–604.

・Hiroi J, McCormick SD, Ohtani-Kaneko R, Kaneko T.
"Functional classification of mitochondrion-rich cells in euryhaline Mozambique tilapia (Oreochromis mossambicus ) embryos, by means of triple immunofluorescence staining for Na+/K+-ATPase, Na+/K+/2Cl- cotransporter and CFTR anion channel."
J Exp Biol 2005 208: 2023–2036.

・Munemasa Y, Ohtani-Kaneko R, Kitaoka Y, Kuribayashi K, Isenoumi K, Kogo J, Yamashita K, Kumai T, Kobayashi S, Hirata K, Ueno S.
"Contribution of mitogen-activated protein kinases to NMDA-induced neurotoxicity in the rat retina."
Brain Res 2005 1044: 227–240.

・Kato T, Ohtani-Kaneko R, Ono K, Okado N, Shiga T.
"Developmental regulation of activated ERK expression in the spinal cord and dorsal root ganglion of the chick embryo."
Neurosci Res 2005 52: 11–19.

・Hayami R, Sato K, Wu W, Nishikawa T, Hiroi J, Ohtani-Kaneko R, Fukuda M, Ohta T.
"Down-regulation of BRCA1-BARD1 ubiquitin ligase by CDK2."
Cancer Res 2005 65: 6–10.

・Kamijo A, Sugaya T, Hikawa A, Okada M, Okumura F, Yamanouchi M, Honda A, Okabe M, Fujino T, Hirata Y, Omata M, Kaneko R, Fujii H, Fukamizu A, Kimura K.
"Urinary excretion of fatty acid-binding protein reflects stress overload on the proximal tubules."
Am J Pathol 2004 165: 1243–1255.

・Tanaka M, Ohtani-Kaneko R, Yokosuka M, Watanabe C.
"Low-dose perinatal diethylstilbestrol exposure affected behaviors and hypothalamic estrogen receptor-alpha-positive cells in the mouse."
Neurotoxicol Teratol 2004 26: 261–269.

・Hiroi J, Maruyama K, Kawazu K, Kaneko T, Ohtani-Kaneko R, Yasumasu S.
"Structure and developmental expression of hatching enzyme genes of the Japanese eel Anguilla japonica: an aspect of the evolution of fish hatching enzyme gene."
Dev Genes Evol 2004 214: 176–184.

・Iigo M, Fujimoto Y, Gunji-Suzuki M, Yokosuka M, Hara M, Ohtani-Kaneko R, Tabata M, Aida K, Hirata K.
"Circadian rhythm of melatonin release from the photoreceptive pineal organ of a teleost, ayu (Plecoglossus altivelis ) in flow-thorough culture."
J Neuroendocrinol 2004 16: 45–51.

・Igarashi-Migitaka J, Yamada S, Hara M, Sano T, Ozawa Y, Ohtani-Kaneko R, Hirata K.
"Gene expression study of thyrotropin releasing hormone (TRH) receptor using RT-PCR: relationship to clinical and immunohistochemical phenotypes in a series of human pituitary adenomas."
Endocr J 2003 50: 459–467.

・Iigo M, Mizusawa K, Yokosuka M, Hara M, Ohtani-Kaneko R, Tabata M, Aida K, Hirata K.
"In vitro photic entrainment of the circadian rhythm in melatonin release from the pineal organ of a teleost, ayu (Plecoglossus altivelis) in flow-through culture."
Brain Res 2003 982: 131–135.

・Hara M, Yoshida M, Nishijima H, Yokosuka M, Iigo M, Ohtani-Kaneko R, Shimada A, Hasegawa T, Akama Y, Hirata K.
"Melatonin, a pineal secretory product with antioxidant properties, protects against cisplatin-induced nephrotoxicity in rats."
J Pineal Res 2001 30: 129–138.

・Ohtani-Kaneko R, Shiga T, Yamashita K, Masaki R, Hirata K.
"Developmental changes in the localization of activated C-JUN N-terminal kinase (JNK/SAPK) in the chick spinal cord."
J Comp Neurol 2000 426: 622–631.

・Masaki R, Saito T, Yamada K, Ohtani-Kaneko R.
"Accumulation of phosphorylated neurofilaments and increase in apoptosis-specific protein and phosphorylated c-Jun induced by proteasome inhibitors."
J Neurosci Res 2000 62: 75–83.

・Yokosuka M, Matsuoka M, Ohtani-Kaneko R, Iigo M, Hara M, Hirata K, Ichikawa M.
"Female-soiled bedding induced fos immunoreactivity in the ventral part of the premammillary nucleus (PMv) of the male mouse."
Physiol Behav 1999 68: 257–261.

・Hara M, Igarashi J, Yamashita K, Iigo M, Yokosuka M, Ohtani-Kaneko R, Hirata K, Herbert DC.
"Proteins recognized by antibodies against isolated cytological heterochromatin from rat liver cells change their localization between cell species and between stages of mitosis (interphase vs metaphase)."
Tissue Cell 1999 31: 505–513.

・Ohtani-Kaneko R, Takada K, Iigo M, Hara M, Yokosawa H, Kawashima S, Ohkawa K, Hirata K.
"Proteasome inhibitors which induce neurite outgrowth from PC12h cells cause different subcellular accumulations of multi-ubiquitin chains."
Neurochem Res 1998 23: 1435–1443.

・Hara M, Herbert DC, Taniguchi T, Hattori A, Ohtani-Kaneko R, Iigo M, Kato Y, Hirata K.
"Effects of a low-protein diet on prolactin- and growth hormone-producing cells in the rat pituitary gland."
Anat Rec 1998 251: 37–43.

・Iigo M, Sánchez-Vázquez FJ, Hara M, Ohtani-Kaneko R, Hirata K, Shinohara H, Tabata M, Aida K.
"Characterization, guanosine 5'-O-(3-thiotriphosphate) modulation, daily variation, and localization of melatonin-binding sites in the catfish (Silurus asotus ) brain."
Gen Comp Endocrinol 1997 108: 45–55.

・Iigo M, Hara M, Ohtani-Kaneko R, Hirata K, Tabata M, Aida K.
"Photic and circadian regulations of melatonin rhythms in fishes."
Biol Signals 1997 6: 225–232. Review.

・Iigo M, Furukawa K, Hattori A, Ohtani-Kaneko R, Hara M, Suzuki T, Tabata M, Aida K.
"Ocular melatonin rhythms in the goldfish, Carassius auratus."
J Biol Rhythms 1997 12: 182–192.

・Hara M, Iigo M, Ohtani-Kaneko R, Nakamura N, Suzuki T, Reiter RJ, Hirata K.
"Administration of melatonin and related indoles prevents exercise-induced cellular oxidative changes in rats."
Biol Signals 1997 6: 90–100.

・Iigo M, Ohtani-Kaneko R, Hara M, Hattori A, Takahashi H, Tabata M, Suzuki T, Aida K.
"Regulation by guanine nucleotides and cations of melatonin binding sites in the goldfish brain."
Biol Signals 1997 6: 29–39.

・Ohtani-Kaneko R, Asahara M, Takada K, Kanda T, Iigo M, Hara M, Yokosawa H, Ohkawa K, Hirata K.
"Nerve growth factor (NGF) induces increase in multi-ubiquitin chains and concomitant decrease in free ubiquitin in nuclei of PC12h."
Neurosci Res 1996 26: 349–355.

・Iigo M, Furukawa K, Hattori A, Hara M, Ohtani-Kaneko R, Suzuki T, Tabata M, Aida K.
"Effects of pinealectomy and constant light exposure on day-night changes of melatonin binding sites in the goldfish brain."
Neurosci Lett 1995 197: 61–64.

・Hattori A, Migitaka H, Iigo M, Itoh M, Yamamoto K, Ohtani-Kaneko R, Hara M, Suzuki T, Reiter RJ.
"Identification of melatonin in plants and its effects on plasma melatonin levels and binding to melatonin receptors in vertebrates."
Biochem Mol Biol Int 1995 35: 627–634.

・Iigo M, Kobayashi M, Ohtani-Kaneko R, Hara M, Hattori A, Suzuki T, Aida K.
"Characteristics, day-night changes, subcellular distribution and localization of melatonin binding sites in the goldfish brain."
Brain Res 1994 644: 213–220.

・Ohtani-Kaneko R, Hattori A, Hara M, Iigo M, Takada K, Suzuki T.
"Increase in ubiquitin-immunoreactive nuclei in rat pituitary luteinizing hormone cells after castration."
Endocrinology 1992 130: 2545–2548.

・Ohtani R, Kaneko T, Kline LW, Labedz T, Tang Y, Pang PK.
"Localization of calcitonin gene-related peptide in the small intestine of various vertebrate species."
Cell Tissue Res 1989 258: 35–42.

・Kaneko T, Ohtani R, Lewanczuk RZ, Pang PK.
"A novel cell type in the parathyroid glands of spontaneously hypertensive rats."
Am J Hypertens 1989 2: 549–552.

・Oka Y, Ohtani R, Satou M, Ueda K.
"Location of forelimb motoneurons in the Japanese toad (Bufo japonicus): a horseradish peroxidase study."
J Comp Neurol 1989 286: 376–383.

・Ohtani R, Kawashima S.
"Reduction of lipofuscin by centrophenoxine and chlorpromazine in the neurons of rat cerebral hemisphere in primary culture."
Exp Gerontol 1983 18: 105–112.

・対談　藁谷友紀、金子（大谷）律子、坂井徹　【子供たちが夢や希望を育める】「幼児期・学童期の教育のあり方」とは？　『週刊東洋経済』特大号　2023-6-24

・金子（大谷）律子　「成長に不可欠なホルモンたち」　『エデュカーレ』　2023年3月号（0・1・2歳児の深ボリ「発達」シリーズ）

・小野和哉、金子律子、安藤久美子、小野芳世、神山昌也、塚原さち子、塩野鈴佳、鈴木亜也加：デジタル耳栓の自閉スペクトラム症音響過敏者への臨床応用に関する研究．最新精神医学 第27巻 第5号 p377-381,2022.9.25

・金子（大谷）律子　「ニューロダイバーシティとは何か」　『月刊先端教育』2022年6月号(真の国際人に必要な資質・能力の育成法 グローバル人材どう育てる)

・金子（大谷）自閉症スペクトラム症(ASD)モデル動物(CRMP4欠損マウス)研究から明らかになったこと.　 行動科学 = Behavioral science research 59 (2), 57-64, 2021-03

・ホルモンのはたらきパーフェクトガイド : とことん解説人体と健康ビジュアル.　 Whitlock, Catherine, Temple, Nicola, 金子 (大谷） 律子（監修）、 関谷　冬華（訳）日経ナショナルジオグラフィック社 2021

・チャート基礎医学シリーズ3　発生学　著：志水義房、白澤信行、金子律子　医学評論社 1992-7-23

・金子律子（大谷律子）．自閉症性差形成メカニズム「性ステロイド仮説」を自閉症モデルマウスを用いて検証する

　基盤研究（C）　2020-04-01－2023-03-31

・土屋貴大．近位依存性ビオチン標識を用いたライリンの新規相互作用分子の同定による機能解明

　若手研究　2019-04-01－2021-03-31

・金子律子（大谷律子）．CRMP4タンパク質が関わる脳の性差についての研究

　基盤研究（C）　2016-10-21－2019-03-31

・金子律子（大谷律子）．CRMP4タンパク質の機能解析－視床下部と嗅球を中心として－

　基盤研究（C）　2013-04-01－2016-03-31

・土屋貴大．ＣＲＭＰ４蛋白質による脳発達機構の解明

　形態・構造　2013-04-01－2016-03-31

・金子律子（大谷律子）．脳の性差形成におけるコラプシン応答メディエーター蛋白質4(CRMP4)の機能解析 

　基盤研究（C）　2010-2012

・金子豊二．魚類の浸透圧調節機構における鰓、腸、腎臓の相互作用および内分泌系による機能の統合

　基盤研究（B）　2007-2009

・金子律子（大谷律子）．脳の性差発現機構の解明

　特定領域研究　2007-2008

・渡辺知保．作用点が複数ある低用量化学物質の毒性の解析法

　萌芽研究　2006-2007

・長田賢一．抗うつ薬奏功蛋白質の新規ケミカルプロテオミクス法を用いた探索と蛋白質クローニング

　基盤研究（C）　2006-2007

・吉田稔．胎生期の低濃度の複合水銀暴露による神経行動毒性に対する加齢及び遺伝的要因の影響

　基盤研究（C）　2006-2007

・金子律子（大谷律子）．シナプス形成に及ぼすステロイドホルモンのnon-genomicな作用と作用機序

　基盤研究（C）　2005-2007

・金子律子（大谷律子）．周生期の視床下部シナプス形成に及ぼすエストロゲンの作用と作用機序

　特定領域研究　2005-2006

・渡辺知保．視床下部ニューロンのシナプス形成における内分泌攪乱物質の低用量効果

　特定領域研究　2002-2003

・金子律子（大谷律子）．神経系発生過程でのc-Jun N-terminal Kinase(JNK)の機能

　基盤研究（C）　2001-2003

・渡辺知保．内分泌攪乱物質の低用量効果のメカニズムとしてのGnRHニューロンのシナプス形成

　特定領域研究（A）　2001

・金子律子．NGFにより誘導されるPC12細胞該内のユビキチンおよびユビキチン化蛋白

　基盤研究（C）　1995-1996

・金子律子．発生過程において神経細胞核内に出現するユビキチン蛋白の機能についての研究

　奨励研究（A）　1993

・金子律子．幼若ラット皮質脊髄路で起こる軸索側枝消去過程の形態学的研究

　一般研究（C）　1991-1992

・金子律子．ラット皮質脊髄路起始ニューロンの樹状突起の発達

　奨励研究（A）　1986

・金子律子．ラット皮質脊髄路起始ニューロンの生後発達

　奨励研究（A）　1985