Research　Projects

Student Research Projects

Developing a Decision-Making Process Model for the Organizational Adoption of Injury Prevention Technology in Sports Teams

Research Projects

"Osekkai" (Behavior Change) Platform

Health-related behavior change depends not only on the individual's own intentions but also on changes in their surrounding environment and the people around them. We are exploring system designs that promote behavior change for lifestyle disease prevention, detect stress, share information with others, and modify the environment to prevent mental illness.

We are planning and conducting demonstration experiments where subjective and objective stress data are entered into the platform, and the analysis results are shared not only with the individual but also with members of their organization.

(Collaborative research with researchers from Institute of Science Tokyo, Keio University, Osaka University, and Tokyo Information Design Professional University, along with student and public volunteers)

https://koara.lib.keio.ac.jp/xoonips/modules/xoonips/listitem.php?index_id=78895 https://www.kgri.keio.ac.jp/docs/L0120250206_digest.pdf https://www.kgri.keio.ac.jp/docs/L0120250206_full.pdf

Perceptions of Health among People with Diseases and Disabilities

We are developing a behavior change platform for health promotion. In the process, we noticed that the current concept of healthy life expectancy may implicitly exclude people with diseases and disabilities. Health policies are premised on the value of being healthy, but as society ages, the number of people living with diseases and disabilities will continue to grow. This research aims to critically examine the current concept of healthy life expectancy and construct a new perspective on health that incorporates the viewpoints of people with diseases and disabilities.

So far, our surveys on perceptions of healthy life expectancy among cancer patients and dialysis patients in Japan have suggested a correlation between high life satisfaction and the belief that "healthy life expectancy can be achieved even with illness or disability." In addition to our research in Japan, we are conducting surveys in the UK, where individual rights and inclusion are strongly advocated, to compare perceptions of healthy life expectancy between people with and without diseases.

https://doi.org/10.1002/hsr2.71533
https://doi.org/10.1016/j.ahr.2025.100262

Simulation of Social Impact of the "Osekkai" (Behavior Change) Platform

We are using system dynamics methods to simulate the impact of a platform promoting healthy behavior change on the number of lifestyle disease patients and healthcare costs across Japan, as well as the diffusion of such behavior change platform services.

(Institute of Science Tokyo, Keio University, Tokyo Information Design Professional University)

https://doi.org/10.1504/ijasm.2025.10072431

https://doi.org/10.1504/ijasm.2024.10065075 https://doi.org/10.3233/atde240937

Building Agile Organizations that Respond to Changing External Environments

During the COVID-19 pandemic, demand for both diagnostic and screening tests surged at university hospitals, making it impossible to cope with existing testing systems alone. At many universities, affiliated hospitals with clinical functions collaborated with medical schools possessing PCR equipment and specialized personnel to spontaneously establish temporary testing systems. However, due to the exceptional circumstances of the crisis, the processes for building such collaborative structures, decision-making, and structural relationships between organizations were not systematically recorded. Only scattered descriptive reports of individual institutions' efforts exist, and comprehensive nationwide surveys or verifiable structural records are extremely rare.

From an organizational theory perspective, existing research on temporary organizations has mainly focused on projects within single organizations. The complex dynamics of multiple existing organizations with different functions and institutional backgrounds rapidly collaborating to build temporary systems under unpredictable circumstances, flexibly restructuring in response to changing situations, and dissolving as crises subside are not well understood.

We are using the Unified Architecture Framework (UAF), a standardized systems engineering framework, to structurally visualize architectural information on inter-organizational collaboration in the temporary PCR testing systems that Japanese medical schools and affiliated hospitals collaboratively established during the COVID-19 pandemic. Our goal is to provide practical design insights for future crisis response.

(Institute of Science Tokyo, Keio University)

https://doi.org/10.2147/rmhp.s441618

https://doi.org/10.21820/23987073.2023.2.42

Papers

・Perceptions of “Healthy Life Expectancy” of Individuals With Diseases: An Online Survey in Japan
　Kyunghee Lee, Kazumi Ota, Tetsuya Toma, Masako Toriya
　Health Science Reports, Nov 2025

・Disease and Disability Representation in Japanese Newspaper Articles on Healthy Life Expectancy: A Text Mining Analysis
　Kazumi Ota, Kyunghee Lee, Masako Toriya
　Aging and Health Research, Sep 2025

・System Design of Behavioural Change Platform Service for Health Promotion Using Digital Healthcare Technologies
　Tetsuya Toma, Masako Toriya, Shingo Kawai
　International Journal of Agile Systems and Management, 1(1), Jan 2025

・Research Team Diversity Impacts Scientific Output in Allergy and Immunology Programs
　Takeya Adachi, Norika Narimatsu, Yasushi Ogawa, Masako Toriya, Tamami Fukushi, Masashi Shirabe, Masaki Futamura, Takenori Inomata, Keigo Kainuma, Keiko Kan-O, Yosuke Kurashima, Katsunori Masaki, Saeko Nakajima, Masafumi Sakashita, Sakura Sato, Mayumi Tamari, Hideaki Morita, Amane Koizumi
　The World Allergy Organization Journal, 18(1), 101004, Jan 2025

・System Dynamics Simulation for Reducing the Number of Lifestyle-Related Disease Patients and Medical Costs in Japan by Promoting Behavioural Changes in Multiple Generations
　Tetsuya Toma, Masako Toriya, Shingo Kawai
　International Journal of Agile Systems and Management, 1(18), 52–73, 2025

・System Design of Behavioural Change Platform Service Using Digital Healthcare Technologies
　Shingo Kawai, Masako Toriya, Tetsuya Toma
　Advances in Transdisciplinary Engineering, Dec 3, 2024

・Development of a Museum Evaluation Framework for Finding Museum Values through Dialogue
　Masako Toriya, Takayuki Ako, Atsushi Noguchi
　The KeMCo Review, 02, 47–62, Apr 2024

・Using a Systems Engineering Approach to Build a PCR Testing System at a Medical School During the COVID-19 Pandemic
　Junna Oba, Masako Toriya, Yoshifumi Uwamino, Koichi Matsuo
　Risk Management and Healthcare Policy, 17, 649–662, Mar 2024

・Multiple Use Case Analysis of an AI Hospital Using the AIDAF and Intelligence Amplification Design Canvas
　Jean Paul Sebastian Piest, Masahiro Jinzaki, Yoshimasa Masuda, Masako Toriya, Osamu Nakamura, Tetsuya Toma
　Lecture Notes in Business Information Processing (LNBIP), 498, 5–22, Mar 2024

・System Dynamics Simulation to Reduce the Number of Patients with Lifestyle-Related Diseases and Medical Costs in Japan by Promoting Behavioral Change
　Shingo Kawai, Masako Toriya, Tetsuya Toma
　Advances in Transdisciplinary Engineering, 41, 791–800, Nov 7, 2023

・A Team Performance Measurement by Pulse Survey Results of Corporate Planning Members
　Tomiya Kimura, Midori Sugihara, Mayu Takaramoto, Masako Toriya, Tetsuya Toma
　Advances in Transdisciplinary Engineering, 28, 259–268, Oct 31, 2022

・Research Impact Analysis of International Funding Agencies in the Realm of Allergy and Immunology
　Takeya Adachi, Yasushi Ogawa, Tamami Fukushi, Kei Ito, Amane Koizumi, Masashi Shirabe, Masako Toriya, Jun Hirako, Takenori Inomata, Katsunori Masaki, Ryohei Sasano, Sakura Sato, Keigo Kainuma, Masaki Futamura, Keiko Kan-O, Yosuke Kurashima, Saeko Nakajima, Masafumi Sakashita, Hideaki Morita, Aikichi Iwamoto, Sankei Nishima, Mayumi Tamari, Hajime Iizuka
　Allergy, 77(5), 1602–1606, May 2022

・Five Indicators for Comprehensive Assessment of University Research Capacity (“Quantity,” “Quality,” and “Thickness”) and a Proposal for a New International Benchmarking Method
　Amane Koizumi, Masashi Shirabe, Masako Toriya
　STI Horizon, 7(1), 2021

・System Design of Science, Technology and Innovation Policy: Discussion of the Fifth Science and Technology Basic Plan Using System Design Method
　Masako Toriya, Nobuyuki Shirakawa, Amane Koizumi, Masashi Shirabe
　STI Horizon, 6(3), 33–37, Jun 2020

・Visualization of Countermeasures against COVID-19 Infections in Japan by Systems Thinking: Why the Japanese Government and Its Council of Experts Could Not Increase PCR Testing
　Masashi Shirabe, Masako Toriya, Amane Koizumi
　Japanese Journal of Science Communication, (27), 21–30, Apr 2020

・System Design of Science, Technology and Innovation Policy: Issues of STI Policy from an Overview and Structural Analysis of the Fifth Science and Technology Basic Plan
　Masako Toriya, Nobuyuki Shirakawa, Amane Koizumi, Masashi Shirabe
　STI Horizon, 6(2), 44–49, 2020

・Introducing Design Thinking in Medical Education
　Masako Toriya et al.
　Kanazawa Medical University Liberal Arts Review, 47, 1–6, 2019

・Brain-Derived Neurotrophic Factor in VMH as the Causal Factor for and Therapeutic Tool to Treat Visceral Adiposity and Hyperleptinemia in Type 2 Diabetic Goto-Kakizaki Rats
　Fumihiko Maekawa, Ken Fujiwara, Masako Toriya, Yuko Maejima, Takashi Nishio, Yukiyasu Toyoda, Keiko Nohara, Takashi Yashiro, Toshihiko Yada
　Frontiers in Synaptic Neuroscience, 5(OCT), 7, 2013

・Neurohormones, Rikkunshito and Hypothalamic Neurons Interactively Control Appetite and Anorexia
　Toshihiko Yada, Daisuke Kohno, Yuko Maejima, Udval Sedbazar, Takeshi Arai, Masako Toriya, Fumihiko Maekawa, Hedeharu Kurita, Akira Niijima, Koji Yakabi
　Current Pharmaceutical Design, 18(31), 4854–4864, Oct 2012

・Downregulation of Notch Mediates the Seamless Transition of Individual Drosophila Neuroepithelial Progenitors into Optic Medullar Neuroblasts during Prolonged G1
　Minako Orihara-Ono, Masako Toriya, Keiko Nakao, Hideyuki Okano
　Developmental Biology, 351(1), 163–175, Mar 1, 2011

・A Study of Research Administrators in Japan
　Masako Toriya, Miyuki Inagaki
　Japan Journal of University Administrative Management, (15), 33–40, 2011

・Long-term Infusion of Brain-Derived Neurotrophic Factor Reduces Food Intake and Body Weight via a Corticotrophin-Releasing Hormone Pathway in the Paraventricular Nucleus of the Hypothalamus
　M. Toriya, F. Maekawa, Y. Maejima, T. Onaka, K. Fujiwara, T. Nakagawa, M. Nakata, T. Yada
　Journal of Neuroendocrinology, 22(9), 987–995, Sep 2010

・Distinct functions of human numb isoforms revealed by misexpression in the neural stem cell lineage in the Drosophila larval brain
　Masako Toriya, Akinori Tokunaga, Kazunobu Sawamoto, Keiko Nakao, Hideyuki Okano
　Developmental Neuroscience, 28(1–2), 142–155, Feb 2006

・Downregulation of Notch, mediated by numb and β-adaptin, is required for the differentiation of postembryonic neural stem cells in Drosophila
　Keiko Nakao, Masako Toriya, Minako Orihara, Miwa Takahashi, Hideyuki Okano
　Zoological Science, 22(12), 1468, Dec 2005

・Function of RNA-binding protein Musashi-1 in stem cells
　Hideyuki Okano, Hironori Kawahara, Masako Toriya, Keiko Nakao, Shinsuke Shibata, Takao Imai
　Experimental Cell Research, 306(2), 349–356, Jun 10, 2005

・Vitronectin promotes neurite extension and regulates DNA synthesis in retinoic acid-induced neuronal differentiated cells in an autocrine manner
　Miyamoto, Y.; Shimizu, S.; Kondo, M.; Toriya, M.; Kaneko, A.; Hayashi, M.
　Molecular Biology of the Cell, 13, 2002

Misc

・【Full Text】Proposal for a Behavioral Transformative Digital Platform for Extending Healthy Life Expectancy Aimed at 2040
　The Extending Healthy Life Expectancy Project Team, Aging Society Innovation Center
　Feb 2025

・【Digest】Proposal for a Behavioral Transformative Digital Platform for Extending Healthy Life Expectancy Aimed at 2040
　The Extending Healthy Life Expectancy Project Team, Aging Society Innovation Center
　Feb 2025

・Identifying Key Issues in Building a Multi-Sided Non-Medical Digital Healthcare Platform Through Pretotyping
　Masako Toriya, Takeo Kato, Wataru Takano, Chizuru Nakajima, Shingo Kawai, Yutaro Hori
　Abstracts of Annual Conference of the Japan Society for Management Information, 202411, 235–238, Jan 31, 2025

・Data Utilization and Governance in Snow Sports Training
　Yoshiaki Fukami, Masako Toriya, Naoki Teramoto, Manami Miyamoto
　Information Systems and Social Environment (IS), 2024-IS-167(15), 1–2, Feb 2024

・International Comparison of the Benefits of Disciplinary Diversity in Research Teams in the Field of Allergy
　Norika Narimatsu, Takeya Adachi, Yasushi Ogawa, Masako Toriya, Tamami Fukushi, Masashi Shirabe, Amane Koizumi
　Proceedings of the Annual Academic Conference, 38, 71–73, Oct 28, 2023

・Proposal for a Behavioral Transformative Digital Platform for Extending Healthy Life Expectancy toward 2040 (Digest Version)
　Independent and Autonomous Society Project, Healthy Life Expectancy Extension Team
　KGRI Working Papers, FY2023, Sep 2023

・Proposal for a Behavioral Transformative Digital Platform for Extending Healthy Life Expectancy toward 2040 (Full Text)
　Independent and Autonomous Society Project, Healthy Life Expectancy Extension Team
　KGRI Working Papers, FY2023, 1–53, Sep 2023

・Envisioning the Future of the Healthcare Industry: Necessary Ecosystem for the Dissemination of Digital Health Technologies – A Backcasting Approach
　Masako Toriya
　Bioscience and Industry, 81(4), 346–348, Jul 2023

・Building a Versatile Medical Test System in a Pandemic
　Junna Oba, Masako Toriya, Koichi Matsuo
　Impact, 2(3), 42–44, Apr 2023

・Research Capability Analysis Considering the Comprehensiveness of Development Methods: A Case Study of COVID-19 Vaccine Development
　Masako Toriya, Masashi Shirabe, Amane Koizumi
　Proceedings of the Annual Academic Conference, 37, 358–360, Oct 29, 2022

・Multidimensional Research Impact Analysis in the Dermatology and Allergy Fields Using Thickness Indicators and Natural Language Processing
　Takeya Adachi, Yasushi Ogawa, Masako Toriya, Tamami Fukushi, Jun Hirako, Masashi Shirabe, Amane Koizumi
　Proceedings of the Japan Society for Research and Innovation Management Annual Conference (CD-ROM), 37th, 2022

・Visualization and Co-Creation of Science, Technology and Innovation Policy Using System Design Methodology: A Theoretical Examination
　Masako Toriya, Masashi Shirabe, Nobuyuki Shirakawa, Amane Koizumi
　Proceedings of the Annual Academic Conference, 35, 501–503, Oct 31, 2020

・Visualization and Co-Creation of Science, Technology and Innovation Policy Using System Design Methodology: Case Analysis
　Masashi Shirabe, Masako Toriya, Nobuyuki Shirakawa, Amane Koizumi
　Proceedings of the Japan Society for Research and Innovation Management Annual Conference (CD-ROM), 35th, 2020

・Survey on the Utilization of Research Evaluation for Formulating University Research Strategies
　Masako Toriya, Amane Koizumi
　Abstracts of the Annual Academic Conference of the Japan Society for Research Policy and Innovation Management, (33), 351–354, Oct 27, 2018

・Impressions through the Wajima Collaboration Project
　Masako Toriya
　Kanazawa Cultural Resource Studies, (18), 20–46, Mar 2018

・Comparison of Tools for Research Performance Analysis
　Masako Toriya
　Journal of the Information Science and Technology Association, 67(4), 171–178, Apr 2017

・Analysis for Research Strategic Planning and Assessment
　Masako Toriya
　Journal of Information Processing and Management, 57(11), 841–844, Feb 2015

・Survey Report on Diabetes Management Using Smartphone Applications
　Shuya Ishida et al., Masako Toriya, Toshinari Takamura
　Journal of the Japan Diabetes Society, 58(Supplement 1), 2015

・Overview of Research Evaluation Tools for University Strategy
　Masako Toriya, Masahiro Yamano
　Current Awareness, (322), 2–4, Dec 20, 2014

・Data Integration for Research Performance Analysis to Strengthen Research Capacity: From the Perspective of a Research Administrator
　Masako Toriya
　Journal of Information Processing and Management, 57(7), 490–493, Oct 2014

・Research Administration and Research Information Resources of University Libraries
　Masako Toriya
　Journal of Information Processing and Management, 57(3), 193–195, Jun 2014

・Exploring the Japanese Model of Research Administrators: Implications of URA Skill Standards for Evaluation, Professionalization, and Human Resource Development
　Makiko Takahashi, Masako Toriya, Shu Yamashita
　Journal of Industry–Academia–Government Collaboration, 9(7), 2013

・Education Programs and Certification for Research Administrators in the United States
　Masako Toriya
　Proceedings of the Annual Conference of the Japan Society for Science and Technology Policy, (27), 511–512, Oct 27, 2012

・Regulation of Feeding by Brain-Derived Neurotrophic Factor (BDNF)
　Fumihiko Maekawa, Masako Toriya, Yuko Maejima
　Endocrinology, Diabetes and Metabolism Clinics, 34(1), 59–64, 2012

・Genetic Disorders of BDNF and TrkB in Obesity
　Fumihiko Maekawa, Udval Sedbazar, Masako Toriya
　Japanese Journal of Clinical Medicine, 68, 268–271, 2010

・Age-Dependent Hyperphagia and Visceral Fat Accumulation in GK Rats and Central Nervous Mechanisms
　Fumihiko Maekawa, Akihiko Ando, Masako Toriya, Toshihiko Yada
　Japanese Journal of Obesity, 15(Supplement), 2009

・Brain-Derived Neurotrophic Factor (BDNF) in the Paraventricular Nucleus Decreases Food Intake
　Masako Toriya, Masanori Nakata, Toshihiko Yada
　Journal of the Japan Society for the Study of Obesity, 15(1), 97–99, 2009

・Central Nervous Mechanisms of Feeding Regulation
　Masako Toriya, Yuko Maejima, Hideharu Kurita, Toshihiko Yada
　Therapeutics, 41(7), 2007

・Mechanisms of Appetite Suppression by Brain-Derived Neurotrophic Factor (BDNF)
　Masako Toriya, Tatsushi Onaka, Toshihiko Yada
　Japanese Journal of Obesity, 13(Supplement), 257, 2007

・Hypothalamic Nuclei Sense Metabolic Signals and Regulate Feeding
　Daisuke Kohno, Masako Toriya, Toshihiko Yada, Hideharu Kurita, Motoki Kuramochi
　Nippon Rinsho (Japanese Journal of Clinical Medicine), 64(Suppl 9), 91–97, Dec 28, 2006

・Downregulation of NOTCH Mediated by Numb and Alpha-Adaptin Is Required for the Differentiation of Postembryonic Neural Stem Cells in Drosophila
　Keiko Nakao, Masako Toriya, Miwa Takahashi, Minako Orihara, Hideyuki Okano
　Mechanisms of Development, 122, S184, Sep 2005

・The Potential of Endogenous Adult Neural Stem Cells for Brain Repair
　Kazunobu Sawamoto, Masako Toriya, Yoshitomo Nomura, Hideyuki Okano
　Journal of Pediatric Surgery, 36(11), 1351–1356, 2004

・Vitronectin Promotes Neurite Extension and DNA Synthesis in Retinoic Acid-Induced Neuronal Differentiated Cells
　Seiko Shimizu, Yasunori Miyamoto, Mitsue Kondo, Masako Toriya, Akira Kaneko, Masao Hayashi
　Annual Meeting of the Japan Matrix Club, 50, 22, 2003

・Regulation of Integrin αv Expression by Transcription Factors Sp1, Ets, and NF-κB in Neuroblastoma Cells
　Yasunori Miyamoto, Ayako Hashimoto, Masako Toriya, Masao Hayashi
　Proceedings of the Annual Meeting of the Japanese Society for Cell Biology, 55th, 68, 2002

・Effects of Vitronectin and Fibronectin on Neuronal Differentiation of Mouse Teratocarcinoma P19 Cells
　Masako Toriya, Yasunori Miyamoto, Masao Hayashi
　Proceedings of the Annual Meeting of the Japanese Society for Cell Biology, 52nd, 49, 1999

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