Research interests:

(1) Inflammation and Primary Immune Deficiencies - The immune system protects the body through inflammation, but when this response becomes dysregulated, it can cause harm. My research explores these mechanisms in genetic disorders that predispose individuals to infections and chronic inflammation. I have investigated conditions arising from defects in viral nucleic acid sensors and proteins essential for immune cell activation.

(2) Cytokines as Regulators of Immune Cell Behavior - Identifying genetic causes is only the first step, patients are often treated with broad immunosuppressants that lack precision. My work focuses on cytokines, the signaling proteins that coordinate immune responses, to develop targeted strategies for controlling inflammation. A key discovery was revealing a novel role of IL-2 in driving T cell dysfunction in HLH, advancing cytokine biology and informing potential therapies for affected children.

(3) Other Projects - I am currently developing diagnostic tools for immune-related diseases. Previously, I co-led projects on single-cell immune profiling to assess cytokine secretion and the cytotoxic activity of immune effector cells. Additionally, I contributed to an in vivo CRISPR/Cas9-based approach aimed at correcting mutations responsible for sight loss.