The Genomic Analysis Laboratory focuses on studying the occurrence of genetic variants and their effects on functional phenotypic changes through large-scale genomic data analysis. Specifically, we specialize in somatic mutations that accumulate during cell division and the resulting phenomenon of somatic mosaicism, where individual cell populations form unique genomic patterns.

 Our lab develops experimental and analytical methodologies to detect somatic mosaicism from large-scale genomic sequencing data. Through mutational signature analysis of detected somatic mutations, we trace the origins of these variations. Furthermore, we utilize mutational lineage analysis to explore early human developmental processes that are experimentally challenging to study.

 Additionally, we perform functional interpretation of somatic mutations by integrating diverse multi-omic datasets. This allows us to investigate the impact of somatic mutations on human development, aging, and their associations with various diseases.

Key Research Areas

• High-sensitivity detection of somatic mutations using single-cell and ultra-high-resolution whole-genome sequencing data analysis

• Mosaic genome analysis to uncover mechanisms of development, aging, and disease progression

• Functional interpretation of genetic variants through integrated multi-omics data analysis

News

July, 2025. YuJin Kim joined the lab as Student intern. Welcome!

March, 2025. Seoyeon Kim joined the lab as an incoming Ph.D student. Welcome!

March, 2025. Dongwon Yun, Minje Sung, Younghoon Jung joined the lab as an incoming master's student. Welcome!

November, 2024. Jiwon Lee joined the Lab as Student intern. Welcome!

September, 2024. The Genomic Analysis Lab opened.