Recent Publications
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2022
Noncanonical activation of GLI signaling in SOX2+ cells drives medulloblastoma relapse.
Swiderska-Syn M, Mir-Pedrol J, Oles A, Schleuger O, Salvador AD, Greiner SM, Seward C, Yang F, Babcock BR, Shen C, Wynn DT, Sanchez-Mejias A, Gershon TR, Martin V, McCrea HJ, Lindsey KG, Krieg C, Rodriguez-Blanco J.Sci Adv. 2022 Jul 22;8(29):eabj9138. doi: 10.1126/sciadv.abj9138. Epub 2022 Jul 20. PMID: 35857834
Enhancing CDK4/6 inhibitor therapy for medulloblastoma using nanoparticle delivery and scRNA-seq-guided combination with sapanisertib.
Lim C, Dismuke T, Malawsky D, Ramsey JD, Hwang D, Godfrey VL, Kabanov AV, Gershon TR, Sokolsky-Papkov M.Sci Adv. 2022 Jan 28;8(4):eabl5838. doi: 10.1126/sciadv.abl5838. Epub 2022 Jan 26. PMID: 35080986
Neoplastic and immune single-cell transcriptomics define subgroup-specific intra-tumoral heterogeneity of childhood medulloblastoma.
Riemondy KA, Venkataraman S, Willard N, Nellan A, Sanford B, Griesinger AM, Amani V, Mitra S, Hankinson TC, Handler MH, Sill M, Ocasio J, Weir SJ, Malawsky DS, Gershon TR, Garancher A, Wechsler-Reya RJ, Hesselberth JR, Foreman NK, Donson AM, Vibhakar R.Neuro Oncol. 2022 Feb 1;24(2):273-286. doi: 10.1093/neuonc/noab135. PMID: 34077540
2021
Oligodendrocytes depend on MCL-1 to prevent spontaneous apoptosis and white matter degeneration.
Cleveland AH, Romero-Morales A, Azcona LA, Herrero M, Nikolova VD, Moy S, Elroy-Stein O, Gama V, Gershon TR. Cell Death Dis. 2021 Dec 6;12(12):1133. doi: 10.1038/s41419-021-04422-z. PMID: 34873168
Cryptic developmental events determine medulloblastoma radiosensitivity and cellular heterogeneity without altering transcriptomic profile.
Malawsky DS, Weir SJ, Ocasio JK, Babcock B, Dismuke T, Cleveland AH, Donson AM, Vibhakar R, Wilhelmsen K, Gershon TR.Commun Biol. 2021 May 21;4(1):616. doi: 10.1038/s42003-021-02099-w.PMID: 34021242
Antiapoptotic Bcl-2 family proteins BCL-xL and MCL-1 integrate neural progenitor survival and proliferation during postnatal cerebellar neurogenesis.
Veleta KA, Cleveland AH, Babcock BR, He YW, Hwang D, Sokolsky-Papkov M, Gershon TR.Cell Death Differ. 2021 May;28(5):1579-1592. doi: 10.1038/s41418-020-00687-7. Epub 2020 Dec 8.PMID: 33293647
Poly(2-oxazoline) nanoparticle delivery enhances the therapeutic potential of vismodegib for medulloblastoma by improving CNS pharmacokinetics and reducing systemic toxicity.
Hwang D, Dismuke T, Tikunov A, Rosen EP, Kagel JR, Ramsey JD, Lim C, Zamboni W, Kabanov AV, Gershon TR, Sokolsky-Papkov PhD M.Nanomedicine. 2021 Feb;32:102345. doi: 10.1016/j.nano.2020.102345. Epub 2020 Nov 28.PMID: 33259959
2020
Content and Performance of the MiniMUGA Genotyping Array: A New Tool To Improve Rigor and Reproducibility in Mouse Research.
Sigmon JS, Blanchard MW, Baric RS, Bell TA, Brennan J, Brockmann GA, Burks AW, Calabrese JM, Caron KM, Cheney RE, Ciavatta D, Conlon F, Darr DB, Faber J, Franklin C, Gershon TR, Gralinski L, Gu B, Gaines CH, Hagan RS, Heimsath EG, Heise MT, Hock P, Ideraabdullah F, Jennette JC, Kafri T, Kashfeen A, Kulis M, Kumar V, Linnertz C, Livraghi-Butrico A, Lloyd KCK, Lutz C, Lynch RM, Magnuson T, Matsushima GK, McMullan R, Miller DR, Mohlke KL, Moy SS, Murphy CEY, Najarian M, O'Brien L, Palmer AA, Philpot BD, Randell SH, Reinholdt L, Ren Y, Rockwood S, Rogala AR, Saraswatula A, Sassetti CM, Schisler JC, Schoenrock SA, Shaw GD, Shorter JR, Smith CM, St Pierre CL, Tarantino LM, Threadgill DW, Valdar W, Vilen BJ, Wardwell K, Whitmire JK, Williams L, Zylka MJ, Ferris MT, McMillan L, Manuel de Villena FP.Genetics. 2020 Dec;216(4):905-930. doi: 10.1534/genetics.120.303596. Epub 2020 Oct 16.PMID: 33067325
Erbb4 Is Required for Cerebellar Developmentand Malignant Phenotype of Medulloblastoma.
Aldaregia J, Errarte P, Olazagoitia-Garmendia A, Gimeno M, Uriz JJ, Gershon TR, Garcia I, Matheu A.Cancers (Basel). 2020 Apr 17;12(4):997. doi: 10.3390/cancers12040997.PMID: 32316671
Projected t-SNE for batch correction
Aliverti E, Tilson JL, Filer DL, Babcock B, Colaneri A, Ocasio J, Gershon TR, Wilhelmsen KC, Dunson DB.Bioinformatics. 2020 Jun 1;36(11):3522-3527. doi: 10.1093/bioinformatics/btaa189.PMID: 32176244
2019
scRNA-seq in medulloblastoma shows cellular heterogeneity and lineage expansion support resistance to SHH inhibitor therapy.
Ocasio JK, Babcock B, Malawsky D, Weir SJ, Loo L, Simon JM, Zylka MJ, Hwang D, Dismuke T, Sokolsky M, Rosen EP, Vibhakar R, Zhang J, Saulnier O, Vladoiu M, El-Hamamy I, Stein LD, Taylor MD, Smith KS, Northcott PA, Colaneri A, Wilhelmsen K, Gershon TR.Nat Commun. 2019 Dec 20;10(1):5829. doi: 10.1038/s41467-019-13657-6.PMID: 31863004
GSK-3 modulates SHH-driven proliferation in postnatal cerebellar neurogenesis and medulloblastoma.
Ocasio JK, Bates RDP, Rapp CD, Gershon TR.Development. 2019 Oct 10;146(20):dev177550. doi: 10.1242/dev.177550.PMID: 31540917
2018
A New Way to Treat Brain Tumors: Targeting Proteins Coded by Microcephaly Genes?
Lang PY, Gershon TR. A New Way to Treat Brain Tumors: Targeting Proteins Coded by Microcephaly Genes? Bioessays. May 2018, 40(5):e1700243. doi: 10.1002/bies.201700243. Epub Mar 26 2018. Review. PMID:29577351
2017
Pyruvate kinase inhibits proliferation during postnatal cerebellar neurogenesis and suppresses medulloblastoma formation
Tech K, Tikunov AP, Farooq H, Morrissy AS, Meidinger J, Fish T, Green SC, Liu H, Li Y, Mungall AJ, Moore RA, Ma Y, Jones SJM, Marra MA, Vander Heiden MG, Taylor MD, Macdonald JM, and Gershon TR. Pyruvate kinase inhibits proliferation during postnatal cerebellar neurogenesis and suppresses medulloblastoma formation. Cancer Res. Jun 15, 2017, 77(12):3217-3230. doi: 10.1158/0008-5472.CAN-16-3304. Epub May 17 2017. PMID:28515149
2016
ATR maintains chromosomal integrity during postnatal cerebellar neurogenesis and is required for medulloblastoma formation
Lang PY, Nanjangud GJ, Sokolsky-Papkov M, Shaw C, Hwang D, Parker JS, Kabanov AV, and Gershon TR (2016), ATR maintains chromosomal integrity during postnatal cerebellar neurogenesis and is required for medulloblastoma formation, Development Nov 1, 2016, 143(21): 4038-4052. PMID:27803059.
Psychiatric manifestations as initial presentation for pediatric CNS germ cell tumors, a case series
Malbari F, Gershon TR, Garvin JH, Allen JC, Khakoo Y, Levy AS, Dunkel IJ (2016), Psychiatric manifestations as initial presentation for pediatric CNS germ cell tumors, a case series, Child’s Nervous System Aug 2016, 32(8):1359-1362. PMID:27312077
Radiation sensitivity in a preclinical mouse model of medulloblastoma relies on the function of the intrinsic apoptotic pathway
Crowther AJ, Ocasio JK, Fang F, Meidinger J, Wu J, Deal AM, Chang SX, Yuan H, Schmid R, Davis I, Gershon TR (2016), Radiation sensitivity in a preclinical mouse model of medulloblastoma relies on the function of the intrinsic apoptotic pathway, Cancer Research June 1, 2016,76(11):3211-23.PMID:27197166
AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival
Kishton RJ, Barnes CE, Nichols AG, Cohen S, Gerriets VA, Siska PJ, Macintyre AN, Goraksha-Hicks P, de Cubas AA, Liu T, Warmoes MO, Abel ED, Yeoh AE, Gershon TR, Rathmell WK, Richards KL, Locasale JW, Rathmell JC (2016), AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival, Cell Metabolism April 12,2016, 23(4):649-662. PMID:27076078
Essential Function of Dicer in Resolving DNA Damage in the Rapidly Dividing Cells of the Developing and Malignant Cerebellum
Swahari V, Nakamura A, Baran-Gale J, Garcia I, Crowther AJ, Sons R, Gershon TR, Hammond S, Sethupathy P, Deshmukh M (2016), Essential Function of Dicer in Resolving DNA Damage in the Rapidly Dividing Cells of the Developing and Malignant Cerebellum, Cell Reports Jan 12,2016, 14(2):216-224.PMID:26748703
2015
Aspm sustains postnatal cerebellar neurogenesis and medulloblastoma growth in mice
Williams SE, Garcia I, Crowther AJ, Li S, Stewart A, Liu H, Lough KJ, O’Neill S, Veleta K, Oyarzabal EA, Merrill JR, Shih YY, Gershon TR (2015), Aspm sustains postnatal cerebellar neurogenesis and medulloblastoma growth in mice, Development Nov 15,2015, 142(22):3921-32.PMID:26450969
Bax deficiency prolongs cerebellar neurogenesis, accelerates medulloblastoma formation and paradoxically increases both malignancy and differentiation
Garcia I, Crowther AJ, Gama V, Miller CR, Deshmukh M, Gershon TR (2015), Bax deficiency prolongs cerebellar neurogenesis, accelerates medulloblastoma formation and paradoxically increases both malignancy and differentiation, Oncogene Jul 2015,34(29):3881.PMID:26179456
Adaptations of energy metabolism during cerebellar neurogenesis are co-opted in medulloblastoma
Tech K, Deshmukh M, Gershon TR (2015), Adaptations of energy metabolism during cerebellar neurogenesis are co-opted in medulloblastoma, Cancer Letter Jan 28, 2015, 256(2A):268-72. PMID:24569090
ASC deficiency suppresses proliferation and prevents medulloblastoma incidence
Knight ER, Patel EY, Flowers CA, Crowther AJ, Ting JP, Miller CR, Gershon TR, Deshmukh M (2015), ASC deficiency suppresses proliferation and prevents medulloblastoma incidence, Oncogene Jan 15, 2015, 34(3):394-402. PMID: 24469054
Energy metabolism in neurodevelopment and medulloblastoma
Tech K, Gershon TR (2015), Energy metabolism in neurodevelopment and medulloblastoma, Translational Pediatrics Jan 4,2015, 4(1):12-19. PMID:26835355
2014
Early-onset stroke and vasculopathy associated with mutations in ADA2
Zhou Q, Yang D, Ombrello AK, Zavialov AV, Toro C, Zavialov AV, Stone DL, Chae JJ, Rosenzweig SD, Bishop K, Barron KS, Kuehn HS, Hoffmann P, Negro A, Tsai WL, Cowen EW, Pei W, Milner JD, Silvin C, Heller T, Chin DT, Patronas NJ, Barber JS, Lee CC, Wood GM, Ling A, Kelly SJ, Kleiner DE, Mullikin JC, Ganson NJ, Kong HH, Hambleton S, Candotti F, Quezado MM, Calvo KR, Alao H, Barham BK, Jones A, Meschia JF, Worrall BB, Kasner SE, Rich SS, Goldbach-Mansky R, Abinun M, Chalom E, Gotte AC, Punaro M, Pascual V, Verbsky JW, Torgerson TR, Singer NG, Gershon TR, Ozen S, Karadag O, Fleisher TA, Remmers EF, Burgess SM, Moir SL, Gadina M, Sood R, Hershfield MS, Boehm M, Kastner DL, Aksentijevich I (2014), Early-onset stroke and vasculopathy associated with mutations in ADA2, New England Journal of Medicine, March 6,2014, 370(10):911-920. PMID:24552284
2013
Tonic activation of Bax primes neural progenitors for rapid apoptosis through a mechanism preserved in medulloblastoma
Crowther AJ, Gama V, Bevilacqua A, Chang SX, Yuan H, Deshmukh M, Gershon TR (2013), Tonic activation of Bax primes neural progenitors for rapid apoptosis through a mechanism preserved in medulloblastoma, Journal of Neuroscience Nov 13, 2013, 33(46):18098-108. PMID: 24227720
Cerebellar granule neuron progenitors are the source of Hk2 in the postnatal cerebellum
Gershon TR, Crowther AJ, Liu H, Miller CR, Deshmukh M (2013), Cerebellar granule neuron progenitors are the source of Hk2 in the postnatal cerebellum. Cancer and Metabolism Jun 11, 2013, 1(1):15. PMID:24280296
Hexokinase-2 mediated aerobic glycolysis is integral to cerebellar neurogenesis and pathogenesis of medulloblastoma
Gershon TR, Crowther AJ, Tikunov A, Garcia I, Annis R, Yuan H, Miller CR, Macdonald J, Olson J, Deshmukh M (2013), Hexokinase-2 mediated aerobic glycolysis is integral to cerebellar neurogenesis and pathogenesis of medulloblastoma, Cancer and Metabolism Jan 23, 2013, 1:2. Epub
2012
Bax-deficiency prolongs cerebellar neurogenesis, accelerates medulloblastoma formation and paradoxically increases both malignancy and differentiation
Garcia I, Crowther AJ, Gama V, Miller CR, Deshmukh M, Gershon TR (2012), Bax-deficiency prolongs cerebellar neurogenesis, accelerates medulloblastoma formation and paradoxically increases both malignancy and differentiation, Oncogene advance online publication Jun 18, 2012. PMID: 22710714
2010
Tbata modulates thymic stromal cell proliferation and thymus function
Flomerfelt FA, El Kassar N, Gurunathan C, Chua KS, League SC, Schmitz S, Gershon TR, Kapoor V, Yan XY, Schwartz RH, Gress RE (2010), Tbata modulates thymic stromal cell proliferation and thymus function, Journal of Experimental Medicine Oct 25, 2010, 207(11):2521-32. PMID: 20937703
Expression of the neuron-specific protein CHD5 is an independent marker of outcome in neuroblastoma
Garcia I, Mayol G, Rodríguez E, Suñol M, Gershon TR, Ríos J, Cheung NK, Kieran MW, George RE, Perez-Atayde AR, Casala C, Galván P, de Torres C, Mora J, Lavarino C, (2010), Expression of the neuron-specific protein CHD5 is an independent marker of outcome in neuroblastoma, Molecular Cancer Oct 15, 2010, 9:277, PMID: 20950435
2009
Enteric neural crest differentiation in ganglioneuromas implicates Hedgehog signaling in peripheral neuroblastic tumor pathogenesis
Gershon TR, Shiraz A, Qin LX, Gerald WL, Kenney AM, Cheung NK, (2009), Enteric neural crest differentiation in ganglioneuromas implicates Hedgehog signaling in peripheral neuroblastic tumor pathogenesis, PLoS One, Oct 16, 2009, 4(10):e7491, PMID: 19834598
2006
Medulloblastoma: therapy and biological considerations
Gershon TR, Becher OJ (2006), Medulloblastoma: therapy and biological considerations, Current Neurology and Neuroscience Reports May 2006, 6(3):200-6, PMID: 16635428
2005
Temporally regulated neural crest transcription factors distinguish neuroectodermal tumors of varying malignancy and differentiation
Gershon TR, Oppenheimer O, Chin SS, Gerald WL (2005), Temporally regulated neural crest transcription factors distinguish neuroectodermal tumors of varying malignancy and differentiation, Neoplasia, Jun 2005, 7(6):575-84. PMID: 16036108
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