Research

We develop advanced organoid platforms derived from diverse epithelial tissues, including intestine, lung, liver, and tumor samples. By integrating immune components into these systems, we aim to establish physiologically relevant models that capture tissue complexity and enable controlled investigation of tissue-immune dynamics in health and disease.

Using organoid platforms, we investigate how epithelial, stem, and progenitor cells communicate with immune cells during inflammation, infection, and tissue damage. Our goal is to quantitatively dissect how these bi-directional interactions regulate tissue repair, regeneration, and maintenance of homeostasis across barrier organs.

We apply our platforms to understand how epithelial/stem cell-immune communication becomes altered in pathological contexts such as aging, acute injury, and cancer. By using organoid-based platforms, we seek to uncover mechanisms underlying regeneration failure, chronic inflammation, and tumor progression, ultimately guiding future regenerative and immune-modulating therapeutic strategies.

We develop and utilize advanced organoid-based platform (Immune integrated Organoid Model) combined with single-cell and functional perturbation approaches to quantitatively dissect stem cell-immune interactions and tissue dynamics under homeostasis, injury, and disease conditions.

Our long-term goal is to build next-generation immune-integrated tissue models that enable deeper understanding of regeneration failure, immune-driven tissue remodeling, and therapeutic opportunities in aging, injury, and cancer.