Publications

1. Sex-specific APOE4-dependent innate immunity regulates meningeal lymphatics, brain lipids, neuroinflammation, and cognition. Delivanoglou N, Todd KT, Almeida F, Rego S, Changavi A, Spajer M, Ayuso VE, Pinho-Correia LM, Sanchez G, das Neves SP, Barber MJ, Schrader R, Sacilotto P, Martens YA, Heckman MG, Bu G, Tanzi RE, Thomas JL, Fryer JD, Oliveira TG, Shekhar K, Da Mesquita S. Neuron. 2026 Mar 26:S0896-6273(26)00135-2. doi: 10.1016/j.neuron.2026.02.030. Online ahead of print.

2. Emotion perception in Behavior frontotemporal dementia and Alzheimer’s disease: the parahippocampal conundrum. Morais RF, Duro D, Pires R, Lemos R, Lima M, Oliveira TG, Santana I. Cognitive and Behavioral Neurology. 2026. Accepted.

3. Are we ready for amyloid-related imaging abnormalities (ARIA) monitoring? A European survey among neuroradiologists and neurologists by the ESNR/EAN working group. Oliveira TG, Vernooij MW, Frisoni GB, Wiest R, Barkhof F. Eur Radiol. 2026 Jan 6. doi: 10.1007/s00330-025-12214-8.

4. Longitudinal assessment of cognitive decline and resilience in high-level Alzheimer disease neuropathologic change. Richardson TE, Kandoi S, Almeida FC, Rohde SK, Marx GA, Canbeldek L, Hiya S, Maldonado-Díaz C, Samanamud J, Clare K, Slocum CC, Kulumani Mahadevan LS, Chiu LY, Farrell K, Crary JF, Daoud EV, White CL 3rd, Espinoza SE, Gonzales MM, Oliveira TG, Walker JM. Alzheimers Res Ther. 2025 Dec 3;17(1):257. doi: 10.1186/s13195-025-01904-6.

5. Polygenic pathways shape white matter vulnerability to Alzheimer’s disease pathology. Tranfa M, Pieperhoff L, Pontillo G, Luckett ES, Collij LE, Oliveira TG, Tesi N, Vilor-Tejedor N, Altmann A, Roccatagliata L, Pardini M, Holstege H, Reinders M, Payoux P, Martinez-Lage P, Ritchie CW, Waldman A, Wardlaw JM, Gispert JD, Salvadó G, Brunetti A, Mutsaerts HJMM, Wink AM, Barkhof F, Lorenzini L. Alzheimers Res Ther. 2025 Nov 10;17(1):240. doi: 10.1186/s13195-025-01888-3.

6. Social memory deficits and their neural correlates in multiple sclerosis. Magalhães A, Morais M, Amorim L, Coelho A, Morais-Ribeiro R, Gomes C, Oliveira TG, Schafer M, Cerqueira JJ, Meira T. Sci Rep. 2025 Nov 10;15(1):39297. doi: 10.1038/s41598-025-23153-1.

7. Cortical Thickness Subtypes in Cognitively Unimpaired: Network and Transcriptomic Vulnerability. Lorenzini L, Tranfa M, Pieperhoff L, Masserini F, ten Kate M, Pontillo G, Luckett E, Wink AM, Mutsaerts HJ, Oliveira TG, Altomare D, Boada M, den Braber A, Birck C, Buckley C, Farrar G, van der Flier W, Frisoni G, Gismondi R, Gispert JD, Hanseeuw B, Jessen F, Marquié M, Mett A, Ritchie C, Salvadó G, Schöll M, Shekari M, Stephens A, Tijms B, Vállez García D, Vandenberghe R, Visser PJ, Roccatagliata L, Oxtoby N, Pardini M, Barkhof, F. Alzheimers Dement. 2025 Oct;21(10):e70762. doi: 10.1002/alz.70762.

8. Primary age-related tauopathy. Richardson TE, Walker JM, Farrell K, Oliveira TG, White CL 3rd, Crary JF. Acta Neuropathol. 2025 Oct 9;150(1):40. doi: 10.1007/s00401-025-02943-x.

9. Atrophy of the auditory cortex in Alzheimer’s Disease. Menezes A, Coelho A, Morais-Ribeiro R, Oliveira TG. Hear Res. 2025 Sep 14;467:109430. doi: 10.1016/j.heares.2025.109430. Online ahead of print.

10. Amygdala-predominant Lewy bodies associate with cognitive decline and amygdalar atrophy in Alzheimer’s disease neuropathological change. Almeida FC, Santos A, Jesus T, Gauthreaux K, Mock CN, Kukull WA, Crary JF, Oliveira TG. J Neurol. 2025 Sep 12;272(9):629. doi: 10.1007/s00415-025-13360-1.

11. White matter microstructure is differentially impacted by cerebral amyloid angiopathy, neurofibrillary tangles and neuritic plaques co-pathology. Santos A, Almeida FC, Gauthreaux K, Mock CN, Kukull WA, Crary JF, Oliveira TG. Alzheimers Dement. 2025 Oct;21(10):e70637. doi: 10.1002/alz.70637.

12. Enhanced dynamic cerebral autoregulation and impaired vasoreactivity may contribute to white matter damage in hypertension: A correlational tractography and transcranial Doppler study. Fortunato M, Monteiro A, Oliveira TG, Castro P, Polónia J, Azevedo E, Cunha JP, Morais R. Neuroscience. doi: 10.1016/j.neuroscience.2025.06.017. Accepted.

13. Cognitive and neuropsychological trajectories in patients with mixed neurodegenerative pathologies. Almeida FC, Marx GA, Rohde SK, Gonzales MM, Maldonado-Díaz C, Hiya S, Clare K, Samanamud J, Slocum CC, Kauffman J, Koenigsberg DG, Crary JF, Farrell K, White CL, Daoud EV, Walker JM, Oliveira TG*, Richardson TE*. Alzheimers Dement. 2025 Aug;21(8):e70575. doi: 10.1002/alz.70575. (* Co-corresponding Authors / Equal Contribution)

14. Differentiating Memory Deficits in bvFTD, AD, and MCI: A Propensity Score and Volumetric Neuroimaging Analysis of Frontal and Medial Temporal Lobe Contributions. Morais RF, de Carvalho S, Vedor S, Pires R, Jesus T, Lemos R, Duro D, Lima M, Baldeiras I, Oliveira TG, Santana I. Assessment. 2025 Sep 25:10731911251361038. doi: 10.1177/10731911251361038. Online ahead of print.

15. Scratching Beneath the Cortex: Superficial White Matter and Alzheimer Disease. Tranfa M, Oliveira TG. Neurology. 2025 Jul 22;105(2):e213830. doi: 10.1212/WNL.0000000000213830. Epub 2025 Jun 19.

16. Differential involvement of neurotransmitter pathways in AD, bvFTD and MCI: Whole-brain MRI analysis. Morais RF, Sousa JM, Koba C, Andres L, Jesus T, Baldeiras I, Oliveira TG, Santana I. Neurobiol Dis. 2025 Apr 5;209:106897. doi: 10.1016/j.nbd.2025.106897. Online ahead of print.

17. Cognitive impairment in neurodegenerative diseases: A trans-diagnostic approach using a lesion-symptom mapping analysis. Morais RF, Pires R, Jesus T, Lemos R, Duro D, Lima M, Baldeiras I, Oliveira TG, Santana I. Neuroscience. 2025 Mar 19;573:214-227. doi: 10.1016/j.neuroscience.2025.03.034. Online ahead of print.

18. Lewy body co-pathology in Alzheimer’s disease and primary age-related tauopathy (PART) contributes to differential neuropathological, cognitive and brain atrophy patterns. Almeida FC, Santos A, Jesus T, Coelho A, Quintas-Neves M, Gauthreaux K, Mock CN, Kukull WA, Crary JF, Oliveira TG. Alzheimers Dement. 2024. Accepted. doi: 10.1002/alz.14191.

19. Fazekas scale assessment as a cerebrovascular disease MRI marker in Alzheimer’s disease and primary age-related tauopathy. Quintas-Neves M, Almeida FC, Gauthreaux K, Teylan MA, Mock CN, Kukull WA, Crary JF, Oliveira TG. Neuroradiology. 2024. Accepted.

20. Meningeal lymphatic drainage regulates oligodendrocyte survival and brain myelination. das Neves SP, Delivanoglou N, Ren Y, Cucuzza CS, Makuch M, Almeida F, Barber MJ, Sanchez G, Rego S, Schrader R, Faroqui AH, Thomas J, McLean PJ, Oliveira TG, Irani SR, Piehl F, Da Mesquita S. Immunity. 2024 Aug 28:S1074-7613(24)00377-7. doi: 10.1016/j.immuni.2024.08.004. Online ahead of print.

21. Alzheimer’s disease Genetic Pathways Impact on Cerebrospinal Fluid Biomarkers And Imaging Endophenotypes In Non-Demented Individuals. Lorenzini L, Collij LE, Tesi N, Vilor-Tejedor N, Ingala S, Blennow K, Foley C, Frisoni GB, Haller S, Holstege H, van der Lee S, Lage-Martinez P, Marioni RE, McCartney DL, O’ Brien J, Oliveira TG, Payoux P, Reinders M, Ritchie C, Scheltens P, Schwarz AJ, Sudre CH, Waldman AD, Wolz R, Chatelat G, Ewers M, Wink AM, Mutsaerts HJMM, Gispert JD, Visser PJ, Tijms BM, Altmann A, Barkhof F. Alzheimers Dement. 2024. 2024 Jul 29. doi: 10.1002/alz.14096. Online ahead of print.

22. Neuroimaging findings in anti-LGI1 encephalitis: a systematic review and meta-analysis. Almeida FC, Pereira AI, Mendes-Pinto C, Lopes J, Moura J, Videira G, Samões R, Oliveira TG. AJNR Am J Neuroradiol. 2024 Jun 13. doi: 10.3174/ajnr.A8256. Online ahead of print.

23. Differential atrophy along the longitudinal hippocampal axis in Alzheimer’s disease. Morais-Ribeiro R, Almeida FC, Coelho A, Oliveira TG. Eur J Neurosci. 2024 Apr 23. doi: 10.1111/ejn.16361. Online ahead of print.

24. Psychosis in Alzheimer’s disease neuropathology is associated with specific brain MRI atrophy, cognitive and neuropathological changes. Almeida FC, Coelho A, Quintas-Neves M, Teylan MA, Mock CN, Kukull WA, Crary JF, Oliveira TG. Neurobiol Aging. 2024 Mar 2;138:10-18. doi: 10.1016/j.neurobiolaging.2024.02.013.

25. APOE genotype dictates lipidomic signatures in primary human hepatocytes. Almeida FC, Patra K, Giannisis A, Niesnerova A, Nandakumar R, Ellis E, Oliveira TG*, Nielsen HM.* J Lipid Res. 2024 Jan 10:100498. doi: 10.1016/j.jlr.2024.100498. Online ahead of print. (* Co-corresponding Authors / Equal Contribution)

26. Sex-specific patterns of cerebral atrophy and enlarged perivascular spaces in patients with cerebral amyloid angiopathy and dementia. Pinho J, Almeida FC, Araújo JM, Machado Á, Costa AS, Silva F, Francisco A, Quintas-Neves M, Ferreira C, Soares-Fernandes JP, Oliveira TG. AJNR Am J Neuroradiol. 2023 Jun 8. Online ahead of print.

27. Sleep-active MCH-system modulates synaptic plasticity and is vulnerable in early Alzheimer’s Disease. Calafate S, Özturan G, Thrupp N, Vanderlinden J, Santa-Marinha L, Morais-Ribeiro R, Ruggiero A, Bozic I, Rusterholz T, Lorente-Echeverría B, Dias M, Chen WT, Fiers M, Lu A, Vlaeminck I, Creemers E, Craessaerts K, Vandenbempt J, van Boekholdt L, Poovathingal S, Davie K, Thal DR, Wierda K, Oliveira TG, Slutsky I, Adamantidis A, De Strooper B, de Wit J. Nat Neurosci. 2023 May 15. Online ahead of print.

28. Investigator-led clinical research in Portugal: problem identification and proposals for improvement. Ferreira JP, Leite-Moreira A, Costa-Pereira A, Soares A, Robalo-Cordeiro C, Jerónimo C, Gavina C, Pinto FJ, Schmitt F, Saraiva F, Vasques-Nóvoa, Canhão H, Cyrne-Carvalho H , Palmeirim I, Pimenta J, Cabral da Fonseca JE, Firmino-Machado J, Correia-Pinto J, Gonçalves L, Castelo Branco M, Sousa N, Fontes de Carvalho R, Luciano TM, Oliveira TG, Oliveira CR. Acta Médica Portuguesa. 2023. Accepted.

29. Adult alcohol drinking and emotional tone are mediated by neutral sphingomyelinase during development in males. Kalinichenko LS, Mühle C, Jia T, Anderheiden F, Datz M, Eberle A, Eulenburg V, Granzow J, Hofer M, Hohenschild J, Huber SE, Kämpf S, Kogias G, Lacatusu L, Lugmair C, Taku SM, Meixner D, Sembritzki N, Praetner M, Rhein C, Sauer C, Scholz J, Ulrich F, Valenta F, Weigand E, Werner M, Tay N,  McVeigh CJ, Haase J, Wang A, Abdel-Hafiz L, Huston JP, Smaga I, Frankowska M, Filip M, Lourdusamy A, Kirchner P, Ekici AB, Marx LM, Suresh NP, Frischknecht R, Fejtova A, Saied EM, Arenz C, Bozec A, Wank I, Kreitz S, Hess A, Bäuerle T, Ledesma MD, Mitroi DN, Miranda AM, Oliveira TG, Gulbins E, Lenz B, Schumann G, Kornhuber J, Müller CP. Cereb Cortex. 2023 Jan 5;33(3):844-864. doi: 10.1093/cercor/bhac106.

30. Divergent MRI atrophy patterns in Alzheimer’s disease and primary age-related tauopathy. Quintas-Neves M, Teylan MA, Morais-Ribeiro R, Almeida F, Mock CN, Kukull WA, Crary JF, Oliveira TG. Neurobiology of Aging. 2022. In Press. doi: 10.1016/j.neurobiolaging.2022.04.013.

31. Effects of APOE4 allelic dosage on lipidomic signatures in the entorhinal cortex of aged mice. Miranda AM, Ashok A, Chan RB, Zhou B, Xu Y, McIntire LB, Area-Gomez E, Di Paolo G, Duff KE, Oliveira TG*, Nuriel T*. Transl Psychiatry. 2022 Mar 29;12(1):129. doi: 10.1038/s41398-022-01881-6. (* Co-corresponding Authors / Equal Contribution)

32. Influence of Metabolic Syndrome on the Recovery from Idiopathic Sudden Sensorineural Hearing Loss. Breda MS, Menezes AS, Oliveira TG, Dias L. Int Arch Otorhinolaryngol. 2022 Jan 31;26(3):e296-e303. doi: 10.1055/s-0041-1741027. eCollection 2022 Jul.

33. Neutral sphingomyelinase mediates the comorbidity trias of alcohol abuse, major depression and bone defects. Kalinichenko LS, Mühle C, Tay N, Jia T, Anderheiden F, Datz M, Eberle A, Eulenburg V, Granzow J, Hofer M, Hohenschild J, Huber S, Kämpf S, Kogias G, Lacatusu L, Lugmaier C, Taku SM, Meixner D, Tesch N, Preatner M, Rhein C, Sauer C, Scholz J, Ulrich F, Valenta F, Weigand E, Werner M, Mc Veigh CJ, Haase J, Wang A, Abdel-Hafiz L, Huston JP, Smaga I, Frankowska M, Filip M, Lourdusamy A, Kirchner P, Ekici AB, Marx L, Suresh NP, Frischknecht R, Fejtova A, Saied EM, Arenz C, Bozec A, Wank I, Kreitz S, Hess A, Bäuerle T, Ledesma MD, Miranda AM, Oliveira TG, Gulbins E, Lenz B, Schumann G, Kornhuber J, Müller CP. Mol Psychiatry. 2021 Sep 28. doi: 10.1038/s41380-021-01304-w. Online ahead of print.

34. Intracerebral hemorrhage recurrence in patients with and without cerebral amyloid angiopathy. Pinho J, Araújo JM, Costa AS, Silva F, Francisco A, Quintas-Neves M, Soares-Fernandes J, Ferreira C, Oliveira TG. Cerebrovasc Dis Extra. Cerebrovasc Dis Extra. 2021 Jan 27;11(1):15-21.

35. Soccer heading and concussion are not associated with reduced brain volume or cortical thickness. Oliveira TG, Ifrah C, Fleysher R, Stockman M, Lipton ML. PLoS One. 2020 Aug 10;15(8):e0235609.

36. Sphingolipids as Prognostic Biomarkers of Neurodegeneration, Neuroinflammation, and Psychiatric Diseases and their Emerging Role in Lipidomic Investigation Methods. van Kruining D, Luo Q, van Echten-Deckert G, Mielke MM, Bowman A, Ellis S, Oliveira TG, Martinez PM. Adv. Drug Deliv. Rev. 2020 Apr 28. pii: S0169-409X(20)30029-6. doi: 10.1016/j.addr.2020.04.009. [Epub ahead of print]

37. Phospholipase D1 ablation disrupts mouse longitudinal hippocampal axis organization and functioning. Santa-Marinha L, Castanho I, Silva RR, Bravo FV, Miranda AM, Meira T, Morais-Ribeiro R, Marques F, Xu Y, Point du Jour K, Wenk M, Chan RB, Di Paolo G, Pinto V, Oliveira TG. Cell Rep. 2020 Mar 24;30(12):4197-4208.e6.

38. Parkinson’s disease and Fabry Disease: clinical, biochemical and neuroimaging analysis of three pedigrees. Gago MF, Azevedo O, Guimarães A, Vide AT, Lamas NJ, Oliveira TG, Gaspar P, Bicho E, Miltenberger-Miltenyi G, Ferreira J, Sousa N. J Parkinsons Dis. 2020;10(1):141-152. doi: 10.3233/JPD-191704.

39. Magnetic resonance imaging brain atrophy assessment in primary age-related tauopathy (PART). Quintas-Neves M, Teylan MA, Besser L, Soares-Fernandes J, Mock CN, Kukull WA, Crary JF, Oliveira TG. Acta Neuropathologica Comm.  2019 Dec 7; 7: 204. doi:10.1186/s40478-019-0842-z

40. Effects of the LPA1 Receptor Deficiency and Stress on the Hippocampal LPA Species in Mice. Tabbai S, Moreno-Fernández RD, Zambrana-Infantes E, Nieto-Quero A, Chun J, García-Fernández M, Estivill-Torrús G, Rodríguez de Fonseca F, Santín LJ, Oliveira TG, Pérez-Martín M, Pedraza C. Front Mol Neurosci. 2019 Jun 11;12:146.

41. Differential lipid composition and regulation along the hippocampal longitudinal axis. Miranda AM, Bravo FV, Chan RB, Sousa N, Di Paolo G, Oliveira TG. Transl Psychiatry. 2019 Apr 26;9(1):144.

42. Phospholipase D functional ablation has a protective effect in an Alzheimer’s disease Caenorhabditis elegans model. Bravo FV, Da Silva JD, Chan RB, Di Paolo G, Teixeira-Castro A, Oliveira TG. Sci Rep. 2018 Feb 23; 8 (1):3540.

43. Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures. Miranda AM, Lasiecka ZM, Xu Y, Neufeld J, Shahriar S, Simoes S, Chan RB, Oliveira TG, Small SA, Di Paolo G. Nat Commun. 2018 Jan 18;9(1):291.

44. Brain MRI in a patient with classical galactosemia: acute event of unilateral hemispheric cerebral edema. Oliveira TG, Soares-Fernandes JP. Childs Nerv Syst. 2017 Nov;33(11):1879-1880.

45. Lipids under stress--a lipidomic approach for the study of mood disorders. Miranda AM, Oliveira TG. Bioessays. 2015 Nov;37(11):1226-35. Epub 2015 Oct 1.

46. The impact of chronic stress on the rat brain lipidome. Oliveira TG, Chan RB, Bravo FV, Miranda A, Silva RR, Zhou B, Marques F, Pinto V, Cerqueira JJ, Di Paolo G, Sousa N. Mol Psychiatry. 2016 Jan;21(1):80-8. Epub 2015 Mar 10.

47. Differential impact of chronic stress along the hippocampal dorsal-ventral axis. Pinto V, Costa JC, Morgado P, Mota C, Miranda A, Bravo FV, Oliveira TG, Cerqueira JJ, Sousa N. Brain Struct Funct. 2015 Mar;220(2):1205-12.

48. Dynamic myelopathy in Hirayama disease. Pinho J, Machado C, Oliveira TG, Soares I, Magalhães Z, Maré R. Spine J. 2014 Nov 1;14(11):2789-90.

49. Lipocalin 2 modulates the cellular response to amyloid beta. Mesquita SD, Ferreira AC, Falcao AM, Sousa JC, Oliveira TG, Correia-Neves M, Sousa N, Marques F, Palha JA. Cell Death Differ. 2014 Oct;21(10):1588-99.

50. Comparative lipidomic analysis of mouse and human brain with Alzheimer disease. Chan RB, Oliveira TG, Cortes EP, Honig LS, Duff KE, Small SA, Wenk MR, Shui G, Di Paolo G. J Biol Chem. 2012 Jan 20;287(4):2678-88.

51. Interplay between depressive-like behavior and the immune system in an animal model of prenatal dexamethasone administration. Roque S, Oliveira TG, Nobrega C, Barreira-Silva P, Nunes-Alves C, Sousa N, Palha JA, Correia-Neves M. Frontiers in Behavioral Neuroscience, 2011 Feb 7;5:4.

52. Phospholipase D2 ablation ameliorates Alzheimer's disease-linked synaptic dysfunction and cognitive deficits. Oliveira TG, Chan RB, Tian H, Laredo M, Shui G, Staniszewski A, Zhang H, Wang L, Kim TW, Duff KE, Wenk MR, Arancio O, Di Paolo G. J Neurosci. 2010 Dec 8;30(49):16419-28.

53. Phospholipase D in brain function and Alzheimer's disease. Oliveira TG, Di Paolo G. Biochim Biophys Acta. 2010 Aug;1801(8):799-805. Epub 2010 Apr 23. Review.

54. How useful is the assessment of lymphatic vascular density in oral carcinoma prognosis? Longatto Filho A, Oliveira TG, Pinheiro C, de Carvalho MB, Curioni OA, Mercante AM, Schmitt FC, Gattás GJ. World J Surg Oncol. 2007 Dec 11;5:140.

Book Chapters

1. Jesus T, Palma C, Oliveira TG, Alves V (2024) Automatic Hemorrhage Detection in Magnetic Resonance Imaging in Cerebral Amyloid Angiopathy. In: Rocha, A., Adeli, H., Dzemyda, G., Moreira, F., Colla, V. (eds) Information Systems and Technologies. WorldCIST 2023. Lecture Notes in Networks and Systems, vol 799. Springer, Cham.

2. Silva FS, Oliveira TG, Alves V (2021) Study of MRI-Based Biomarkers on Patients with Cerebral Amyloid Angiopathy Using Artificial Intelligence. In: Rocha Á., Adeli H., Dzemyda G., Moreira F., Ramalho Correia A.M. (eds) Trends and Applications in Information Systems and Technologies. WorldCIST 2021. Advances in Intelligent Systems and Computing, vol 1365. Springer, Cham.

Patents 

1. Modulation of Phospholipase D for the treatment of the acute and chronic effects of ethanol. Di Paolo G, Oliveira TG, Wenk M, Frere SG, Chan RB. WIPO Patent WO/2011/014622A1.

2. Modulation of Phospholipase D for the treatment of neurodegenerative disorders. Di Paolo G, Oliveira TG, Kim TW. WIPO Patent WO/2010/138869A1.