Publications

50)  Heterobenzylic C(sp3)─H Acylation of Isoindolinones via Photoinduced Intermolecular Hydrogen Atom Transfer Strategy

Muthuvel, K.; Sivaraj, C.; Gandhi, T. Synlett, 2025, 36, 3373-3377 (Invited)

      Published as part of the Special Issue dedicated to Prof. S. Chandrasekaran on his 80th birthday 

49) Unlocking Cyclic Carbonates as Butadiene Surrogates in Pd-Catalyzed Mizoroki–Heck Reactions

Sekar, M.; Gandhi, T.  Org. Lett., 2025, 27, 10082–10087

48) Ruthenium-catalyzed C(sp2)−H ortho-heteroarylation of phthalazin-1(2H)-one using thiophenes by cross-dehydrogenative coupling

Ramkumar, A.; Gandhi, T.  Org. Biomol. Chem., 2025, 23, 7714 - 7718

47) Spatially Tweaked Amide-Directing Group Enables High-Turnover Pd Catalysts for Site-Selective Remote C–H Arylation

Sivaraj, C.; Gandhi, T.; Maiti, D. ACS Catal., 2025, 15, 11563–11572.

46) Synthesis of lactones and lactams via C(sp3)–H bond functionalization.

Premkumar, E.; Sreedharan, R.; Ghosh, P.; Pal, T.; Maiti, D.; Gandhi, T.   Chem. Soc. Rev., 2025, 54, 6238-6281

45) Ligand-Enabled Photoinduced Ruthenium Catalysis for Ortho-C─O Bond Formation at Room Temperature.

Sivaraj, C.; Udayan, A. T.; Muthuvel, K.; Gandhi. T., Chem. Eur. J., 2025, e202500711.

44)  Site-Selective Remote C4 Amination of 1-Naphthamides via Palladium–Single-Electron Transfer Catalysis

Sivaraj, C.; Maiti, D.; Gandhi, T.   Org. Lett., 2025, 27, 1650–1655.

43)  An expedient ruthenium(ii) catalyzed multicomponent access to phthalazinones bearing trisubstituted alkenes

Sekar, M.; Sreedharan, R.;   Premkumar, E.; Purushothaman, R.; Gandhi, T.  Org. Biomol. Chem., 2025, 23, 2411-2417.

42)  Alternative and Sustainable Route to Explore a New Class of Amidines by Photochemical Synergistic Effect ofCopper/Nitroxyl Radical Catalysis via Halogen-Atom Transfer

Sivaraj, C.; Gandhi, T., Chem. Eur. J., 2025, e202404599.

41)  Engaging vinylene carbonate in ruthenium-catalyzed regioselective C-4 methylenation and C-8 formylmethylation of isoquinolinones

Thalakottukara, D. D.; Gandhi, T. Chem. Commun., 2024, 60, 10358-10361.

40)  Facile Cleavage of Activated Ketones: An Access to Thioethers via In Situ Generation of Anhydrides by Pummerer-Type Rearrangement

Sivaraj, C.;  Muthuvel, K.; Thonipalliyalil, A. U.;  Premkumar, E., Gandhi, T.  J. Org. Chem. 2024, 89, 7020–7026.

39) Masters of Mediation: MN(SiMe3)2 in Functionalization of C(sp3)−H Latent Nucleophiles

Sreedharan, R.; Gandhi, T.  Chem. Eur. J., 2024, 30, e202400435.

38)  Substrate-directed C(sp3)–H borylation via transition metal catalysis: expanding the toolbox for C–H functionalization

Thalakottukara, D.;  Sekar, M.;  Mandal, A.;  Gandhi, T.; Maiti, D.  Catal. Sci. Technol., 2024,14, 5488-5504.

37)  NHC‐catalyzed C3‐acylation of 2‐oxindoles by selective aerobic oxidation of aryl aldehydes.

Muthuvel, K.; Gandhi, T. Asian J. Org. Chem., 2023, e202300599.

36)  Vinylene Carbonate as Latent Formylmethyl Surrogate: The Expediency of Ruthenium (II) Catalysis in Accessing Arylacetaldehydes, Arylacetates and Acetals.

Thalakottukara, D. D.; Gandhi, T. Eur. J. Org. Chem., 2023, e202300847.

35)  Photo‐Catalyzed Acyl Azolium Promoted Selective α‐C (sp3)–H Acylation of Acetone via HAT: Access to Thermodynamically Less Favoured (Z)‐α, β‐Unsaturated Ketones.

Sivaraj, C.; Maiti, D.; Gandhi, T. Chem. Eur. J., 2023, e202303626.

34)  Sustainable Ru(II)-Catalyzed ortho-C(sp2)–H Hydroxyalkylation of Phthalazinones Using Ethyl Glyoxalate: Access to α,α′-Arylcarboxy sec-Alcohols.

Ramkumar, A.; Gandhi, T. Synthesis, 2023, 55, 3610-3616 (Invited).

33)  Brønsted Base Prompted sp3 C–H Latent Nucleophiles to Access α-Branched Amines Bearing β-Carbonyl by Cleaving Amide and Ester Bonds.

Sreedharan, R.; Gandhi, T. J. Org. Chem., 2023, 88, 8480–8492.

32)  Ruthenium(ii)-catalyzed oxidative dehydrogenation and hydroarylation of maleimides with phthalazinones – insights into additive-controlled product selectivity.

Ramkumar, A.; Sreedharan, R.; Rajeshwaran, P.; Gandhi, T., Org. Biomol. Chem., 2023, 21, 2695-2699.

31)  Solvent-controlled amidation of acid chlorides at room temperature: new route to access aromatic primary amides and imides amenable for late-stage functionalization.

Sivaraj, C; Gandhi, T., RSC Adv., 2023, 13, 9231-9236.

30)  Synthesis of α-aryl ketones by harnessing the non-innocence of toluene and its derivatives: Enhancing the acidity of methyl arenes by a Brønsted base and their mechanistic aspects.

Sreedharan, R.; Pal, P. K.; Panyam, P. K. R.; Priyakumar, U. D.; Gandhi, T. Asian J. Org. Chem. 2022, 11, e202200372.

29)  NHC-Organocatalysed hydroacylation of unactivated or weakly activated C-C multiple bonds and ketones.

Thalakottukara, D. D.; Gandhi, T. Asian J. Org. Chem., 2022 (10.1002/ajoc.202200080).

28)  Ene-Reductase: A Multifaceted Biocatalyst in Organic Synthesis.

Kumar Roy, T., Sreedharan, R., Ghosh, P., Gandhi, T., Maiti, D. Chem. - A Eur J., 2022, (10.1002/chem.202103949).

27)  C−F Bond Activation and Functionalizations Enabled by Metal-free NHCs and Their Metal Complexes.

Muthuvel, K., Gandhi, T. ChemCatChem, 2022, (10.1002/cctc.202101579).

Dedicated to Prof. D. Gajapathy on the occasion of his 75th birthday 

26)  Alternative and Uncommon Acylating Agents – An Alive and Kicking Methodology.

Sivaraj, C.; Gandhi, T. Chem. Asian J., 2021, 16, 2773-2794.

Dedicated to the memory of Dr. Rajendran Senthil Kumaran (1976–2021).

25)  Transition-metal-catalyzed C–H bond activation/functionalization and annulation of phthalazinones.

Sivaraj, C.; Ramkumar, A; Nagesh, S.; Gandhi, T. Org. Biomol. Chem., 2021, 19, 8165-8183.

24)  Pyrenoimidazole-fused phenanthridine derivatives with intense red excimer fluorescence in the solid state.

Karthik, S; Ajantha, J; Easwaramoorthi, S; Gandhi, T. New J. Chem., 2020, 44, 9530-9539.

23)  DBU-Promoted α-Acylation of 2-Oxindoles through Acyl C-C bond Cleavage: Imidazolium Salts as an Emerging Acylating Agent.

Muthuvel, K.; Karthik, S.; Gandhi, T. Asian J. Org. Chem. 2020, 9, 769-772.

22)  Acylation of oxindoles using methyl/phenyl esters via the mixed Claisen condensation–an access to 3-alkylideneoxindoles. 

Sreedharan, R.; Rajeshwaran, P.;  Panyam, P. K. R.; Yadav, S.;  Nagaraja, C. M.; Gandhi, T. Org.  Biomol. Chem.,  2020, 18, 3843-3847.

21)  Highly Z-selective synthesis of 1, 3-oxathiol-2-ylidenes and 4-methylene-oxazolidine-2-thiones via atom-specific 5-exo-dig cyclization of propargyl alcohol with isothiocyanate. Savarimuthu,, S. A.; Prakash, D. G. L,; Thomas, S. A.; Gandhi, T.; Bera, M. K. Org.  Biomol. Chem. 2020, 18, 3552-3562.

20)  A Straightforward Metal‐Free and Mild Base Promoted Amidation and Transesterification via Acyl C‐O bond Cleavage‐An Expedite Synthesis of Aromatic Amides and Esters. S Karthik, S.;  Sreedharan, R.;  Gandhi, T., ChemistrySelect, 2019, 4, 175-180.

19)  Base-Promoted Amidation and Esterification of Imidazolium Salts via Acyl C–C bond Cleavage: Access to Aromatic Amides and Esters. S Karthik, S.;  Muthuvel, K.;  Gandhi, T., J. Org. Chem., 2018,  84, 738-751.

18)  DBU‐Mediated Intermolecular 5‐exo‐dig Cyclization of PropargylAlcohols and Carbon Disulfide to [1, 3]‐Oxathiole‐2‐thiones. Savarimuthu, S. A.;  Prakash,  D. G. L.;  Thomas, S. A.;  Gandhi, T.,  ChemistrySelect, 2018, 3, 13087-13090.

17)  Dibenzofuran and dibenzothiophene based palladium (ii)/NHC catalysts–synthesis and applications in C–C bond formation.  Karthik, S.; Gandhi, T. New J. Chem. 2018, 42, 15811-15819.

16)  Palladium(II)/N-Heterocyclic Carbene Catalyzed One-Pot Sequential α-Arylation/Alkylation: Access to 3,3-Disubstituted Oxindoles. Panyam, P. K. R.; Ugale, B.; Gandhi, T. J. Org. Chem., 2018, 83, 7622–7632.

15)  Synthesis of topologically constrained naphthalimide appended palladium (ii)–N-heterocyclic carbene complexes–insights into additive controlled product selectivity. Panyam, P. K. R.;  Sreedharan, R.; Gandhi, T., Org.  Biomol. Chem., 2018, 16, 4357-4364.

14)  Palladium(II)/N-Heterocyclic Carbene-Catalyzed Direct C–H Acylation of Heteroarenes with N-Acylsaccharins. Karthik, S; Gandhi, T,  Org. Lett., 2017, 19, 5486-5489.

13)  Palladium(II)/N-Heterocyclic Carbene-Catalyzed Regioselective Heteroannulation of Tertiary Propargyl Alcohols and o-Haloanilines to form 2-Alkenylindoles, Panyam, P. K. R.; Gandhi, T., Advanced Synthesis & Catalysis 2017, 359, 1144.

12)  Pd-Catalyzed C–H arylation of pyridazine-based fused 1,2,4-triazoles: overriding selectivity at the usual position by undermining of preferred chelate formation, Srinivasan, R.; Dey, A.; Nagarajan, N. S.; Kumaran, R. S.; Gandhi, T.; Maiti, D. Chemical Communications, 2017, 53, 11709.

11)  Alkyl Nitrites: Novel Reagents for One-Pot Synthesis of 3,5-Disubstituted Isoxazoles from Aldoximes and Alkynes, Kadam, K. S.; Gandhi, T.; Gupte, A.; Gangopadhyay, A. K.; Sharma, R. Synthesis, 2016, 48, 3996. 

10)  Expedient synthesis of new cinnoline diones by Ru-catalyzed regioselective unexpected deoxygenation-oxidative annulation of propargyl alcohols with phthalazinones and pyridazinones, Rajkumar, S.; Antony Savarimuthu, S.; Senthil Kumaran, R.; Nagaraja, C. M.; Gandhi, T. Chemical Communications, 2016, 52, 2509.

9)  LiOtBu Promoted 5-Exo-dig Cyclization of Propargyl Alcohols and Isocyanates for the Synthesis of Multisubstituted 3H-Oxazol-2-ones and Oxazolidin-2-ones, Savarimuthu, S. Antony; Thomas, S. Augustine; Prakash, D. G. Leo; Gandhi, Thirumanavelan, ChemistrySelect, 2016, 1, 2035-2039.

8)  Synthesis and photophysics of extended π-conjugated systems of substituted 10-aryl-pyrenoimidazoles, Karthik, S.; Ajantha, J.; Nagaraja, C. M.; Easwaramoorthi, S.; Gandhi, T. Organic & Biomolecular Chemistry, 2016, 14, 10255.

7)  Ru(II)-Catalyzed β-Carboline Directed C-H Arylation and Isolation of Its Cycloruthenated Intermediates, Rajkumar, S.; Karthik, S.; Gandhi, T., The Journal of Organic Chemistry, 2015, 80, 5532.

6)  Synthesis and Reactivity Studies of Dicationic Dihydrogen Complexes Bearing Sulfur-Donor Ligands: A Combined Experimental and Computational Study, Gandhi, T.; Rajkumar, S.; Prathyusha, V.; Priyakumar, U. D. European Journal of Inorganic Chemistry, 2013, 1434.

5)  Heme-Copper-Dioxygen Complexes: Toward Understanding Ligand-Environmental Effects on the Coordination Geometry, Electronic Structure, and Reactivity, Halime, Z.; Kieber-Emmons, M. T.; Qayyum, M. F.; Mondal, B.; Gandhi, T.; Puiu, S. C.; Chufán, E. E.; Sarjeant, A. A. N.; Hodgson, K. O.; Hedman, B.; Solomon, E. I.; Karlin, K. D. Inorganic Chemistry, 2010, 49, 3629.

4)  Reactivity Studies on FeIII-(O22-)-CuII Compounds: Influence of the Ligand Architecture and Copper Ligand Denticity, Chufan, Eduardo E.; Mondal, Biplab; Gandhi, Thirumanavelan; Kim, Eunsuk; Rubie, Nick D.; Moeenne-Loccoz, Pierre; Karlin, Kenneth D., Inorganic Chemistry, 2007, 46, 6382-6394 .

3)  Utilization of CS2 as a Source of C1 Synthetic Units for the Preparation of Bis(alkylthio)methanes and Alkyl Dithioformates, Gandhi, Thirumanavelan; Jagirdar, Balaji R., Inorganic Chemistry, 2005, 44, 1118-1124 .

2)  Utilization of CS2 as a Source of C1 Chemistry for the Generation of Methyldithioformate, Gandhi, Thirumanavelan; Nethaji, Munirathinam; Jagirdar, Balaji R., Inorganic Chemistry, 2003, 42, 4798-4800.

1)  Novel Double Insertion of Carbon Disulfide into Two Ru-H Bonds of [(dppm)2Ru(H)2] (dppm = Ph2PCH2PPh2): Synthesis and Crystal Structure of a Methanedithiolate Complex, Gandhi, Thirumanavelan; Nethaji, Munirathinam; Jagirdar, Balaji R.,  Inorganic Chemistry, 2003, 42, 667-669.