PUBLICATIONS

23. Seok Bin Yang, Doyun Ku, Ji-Hoi Moon, Jae-Hyung Lee, Sang Wook Kang, Hak Kyun Kim* and Kyu Hwan Kwack* Complete genome sequence of Streptococcus hominis isolated from subgingival biofilm. BMC Genom Data 2025 Sep 29;26(1):69. doi: 10.1186/s12863-025-01367-6. *, co-correspondence

22. Hyemin Kim, Saebyeol Lee, Hak Kyun Kim*, Sang-Kyu Park* Xanthoxyline prevents aging and neuronal damage by activating autophagy and DAF-16 expression in Caenorhabditis elegans. Anim Cells Syst (Seoul) 2025 Aug 22;29(1):544-555. doi: 10.1080/19768354.2025.2549756.eCollection 2025. *, co-correspondence

21. Dongjin Kim, Hak Kyun Kim*, Mark A. Kay* Chapter Nineteen - Functional analysis of tRNA-derived small translational regulation in Methods in Enzymology volume 711, pages 336-355 (Jan 3, 2025). *, co-correspondence pdf file

20. Hanyong Jin*, Ji-Hyun Yeom*, Eunkyoung Shin*, Yoonjie Ha*, Haifeng Liu*, Daeyoung Kim*, Minju Joo*, Yong-Hak Kim*, Hak Kyun Kim*, Minkyung Ryu*, Hong-Man Kim*, Jeongkyu Kim, Keun P. Kim, Yoonsoo Hahn, Jeehyeon Bae & Kangseok Lee 5′-tRNAGly(GCC) halves generated by IRE1α are linked to the ER stress response.   Nature Communications volume 15, Article number: 9273 (Oct 28, 2024). *, equal contribution

19. Jeewan Chun, Ji-Hoi Moon, Kyu Hwan Kwack, Eun-Young Jang, Saebyeol Lee, Hak Kyun Kim* & Jae-Hyung Lee* Single-cell RNA sequencing reveals the heterogeneity of adipose tissue-derived mesenchymal stem cells under chondrogenic induction. BMB Rep. 2023 Nov 2:6028. Online ahead of print. *, co-correspondence

18. Yoon-Seob Kim# , Do-Hyung Kim# , Daegi An# , Younghyun Lim , Young-Jin Seo , Hak Kyun Kim*, Ho-Young Kang* The RNA ligation method using modified splint DNAs significantly improves the efficiency of circular RNA synthesis. Anim Cells Syst (Seoul). 2023 Oct 4;27(1):208-218. doi: 10.1080/19768354.2023.2265165.eCollection 2023. *, co-correspondence; #, equal contribution

17. Saebyeol Lee , Jungeun Kim, Paul N Valdmanis, Hak Kyun Kim  Emerging roles of tRNA-derived small RNAs in cancer biology. Exp Mol Med. 2023 Jul;55(7):1293-1304. doi: 10.1038/s12276-023-01038-5.Epub 2023 Jul 10.

16.  Ziwei Liu, Hak Kyun Kim, Jianpeng Xu, Yuqing Jing, Mark A Kay The 3'tsRNAs are aminoacylated: Implications for their biogenesis. Plos Genetics 2021JUl 29, 17(7):e1009675. doi:10.1371/journal.pgen.1009675

15.  Joonhyeong Park, Se Hee Ahn, Myung Geun Shin, Hak Kyun Kim*, Suhwan Chang* tRNA-Derived Small RNAs: Novel Epigenetic Regulators. Cancers 2020 Sep 27, 12(10), 2773; https://doi.org/10.3390/cancers12102773 pdf file  *, correspondence

14.   Hak Kyun Kim*, Ji-Hyun Yeom, Mark A. Kay* Transfer RNA-Derived Small RNAs: Another Layer of Gene Regulation and Novel Targets for Disease Therapeutics. Mol. Ther. 2020 Sep 06; S1525-0016(20)30470-6. doi: 10.1016/j.ymthe.2020.09.013 pdf file  *, correspondence

13.    Hak Kyun Kim, Jianpeng Xu, Kirk Chu, Hyesuk Park, Hagoon Jang, Pan Li, Paul N. Valdmanis, Qiangfeng Cliff Zhang, Mark A. Kay.  A tRNA-derived small RNA regulates ribosomal protein S28 protein level after translation initiation in humans and mice. Cell Reports (2019 Dec 17) 29 (12): 3816-3824.e4 pdf file 

12.    Hak Kyun Kim*. Transfer RNA-derived small non-coding RNA: dual regulator of protein synthesis. Mol Cells. (2019 Oct 31):42(10):687-692 pdf file *, correspondence

11.     Paul N. Valdmanis, Hak Kyun Kim, Kirk Chu, Feijie Zhang, Jianpeng Xu, Elizabeth M. Munding, Jia Shen, and Mark A. Kay. miR-122 removal in the liver activates imprinted microRNAs and enables more effective microRNA-mediated gene repression. Nature Communications (2018 Dec 14) 9, Article number 5321. Doi.org/10.1038/s41467-018-07786-7 pdf file 

10.     Hak Kyun Kim, Gabriele Fuchs, Shengchun Wang, Wei Wei, Yue Zhang, Hyesuk Park, Biswajoy Roy-Chaudhuri, Pan Li, Jianpeng Xu, Kirk Chu, Feijie Zhang, Mei-Sze Chua, Samuel So, Qiangfeng Cliff Zhang, Peter Sarnow, Mark A. Kay. A transfer-RNA-derived small RNA regulates ribosome biogenesis. Nature 2017 Dec 07;552(7683):57-62. doi:10.1038/nature25005 pdf file & lecture movie

9.     Chak K, Roy-Chaudhuri B, HK Kim, Kemp KC, Porter PE, Kay MA. Increased precursor microRNA-21 following status epilepticus can compete with mature microRNA-21 to alter translation. Exp neurol. (2016 Dec) 286:137-146

8.     PN Valdmanis, B Roy-Chaudhuri, HK Kim, LC Sayles, Y Zheng, C-H Chuang, DR Caswell, K Chu, MM Winslow, EA Sweet-Cordero and MA Kay. Upregulation of the microRNA cluster at the Dlk1-Dio3 locus in lung adenocarcinoma. Oncogene (2015) 34,94-103

7.     Dandan Sun, Yong Sun Lee, Ankit Malhotra, Hak Kyun Kim, Mirela Matecic, Clive Evans, Roderick V Jensen, Christopher A Moskaluk, Anindya Dutta (2011) miR-99 family of microRNAs suppresses the expression of prostate specific antigen and prostate cancer cell proliferation. Cancer Res., 2011 Feb 15;71(4):1313-24

 6.     Kim HK*, Lee YS*, Sivaprasad U, Malhotra A and Dutta A.  Muscle-specific microRNA miR-206 promotes muscle differentiation.  J Cell Biol.  (2006) 174, 677-687. * equal contribution

 5.     Lee, Y.S., Kim, H.K., Chung, S., Kim, K.S., Dutta, A., (2005) Depletion of human microRNA miR-125b reveals that it is critical for the proliferation of differentiated cells but not for the down-regulation of putative targets during differentiation. J Biol Chem. 29;280(17):16635-41

 4.     The ENCODE Project Consortium (2004) The ENCODE (ENCyclopedia Of DNA Elements) Project. Science306: 636-640

 3.     Joo Seok Han, Sukhyun Kang, Ho Lee, Hak Kyun Kim and Deog Su Hwang., (2003) Sequential binding of SeqA to paired hemi-methylated GATC sequences mediates   formation of higher-order complexes. J Biol Chem. 12;278(37):34983-9

 2.  Yong Sun Lee, June Lee, Hak Kyun Kim, et al. (2003) Trigger factor interacts with DnaA protein to stimulate its interaction with DnaA Box. Korean J Biol Sci. 7:81-87

 1.  Lee H, Kim HK, Kang S, Hong CB, Yim J, Hwang DS. (2001) Expression of the seqA gene is negatively modulated by the HU protein in Escherichia coli. Mol. Gen. Genet. 264:931-5