THERAPEUTIC ENGINEERING LAB
Department of Chemical Engineering, Indian Institute of Science
Our research involves the engineering of treatments and the establishment of principles of the design of novel drugs and vaccines that would lead to improved health care. We focus on infectious diseases caused by pathogens such as HIV, hepatitis C virus, and mycobacterium tuberculosis, which today together affect hundreds of millions worldwide. Why are these pathogens more virulent than the ones, for instance, causing common cold? Why are some individuals successful in clearing these infections while others succumb? How do these pathogens develop resistance to drugs and evade vaccines? We develop mathematical models and simulations of the dynamics of infections caused by these pathogens that present a fundamental understanding of disease progression and the impact of intervention and provide a framework for rational therapy optimization with available drugs and facilitate the identification of guidelines for the design of new drugs and vaccines potent against these virulent, rapidly evolving pathogens. We aim to establish improved therapeutic protocols that impede therapy failure, minimize side effects, and personalize treatments, enabling more effective combat of infectious diseases.
Nov 11, 2020: Paper accepted - Saha et al. Pre-existing resistant proviruses can compromise maintenance of remission by VRC01 in chronic HIV-1 infection. PLoS Computational Biology.
Sep 22, 2020: In media - Scientists solve mystery of how antibodies stop HIV reinfection. Deccan Herald.
Aug 20, 2020: Paper published - Desikan et al. Early exposure to broadly neutralizing antibodies may trigger a dynamical switch from progressive disease to lasting control of SHIV infection. PLoS Computational Biology.
Nov 12, 2019: Paper accepted - Ansari et al. High-order interactions can eclipse pairwise interactions in shaping the structure of microbial communities. Industrial and Engineering Chemistry Research.
Nov 7, 2019: Paper accepted - Garg et al., Preferential presentation of high-affinity immune complexes in germinal centers can explain how passive immunization improves the humoral response. Cell Reports.
Oct 13, 2019: Paper published - Sen et al., You Cannot Have Your Synergy and Efficacy Too, Trends in Pharmacological Sciences, Link
Aug 14, 2019: Paper published - Baral et al., A dynamical motif comprising the interactions between antigens and CD8 T cells may underlie the outcomes of viral infections, PNAS. Link
Jun 24, 2019: Paper published - Dave et al., Strand-specific affinity of host factor hnRNP C1/C2 guides positive to negative-strand ratio in Coxsackievirus B3 infection, RNA Biology. Link
Jun 1, 2019: Aamir Faisal Ansari was awarded 'the best poster presentation' prize in the departmental symposium.
Apr 1, 2019: Paper Published - Raja et al., Mutational pathway maps and founder effects define the within-host spectrum of hepatitis C virus mutants resistant to drugs, PLoS Pathogens. Link
Feb 18, 2019: Gaurav D. Sankhe defended his PhD thesis titled "Insights into signalling and crosstalk in two-component signalling systems of Mycobacterium tuberculosis".
Feb 5, 2019: Paper published - Baral S, Raja R, Sen P, Dixit NM. Towards multiscale modeling of the CD8+ T cell response to viral infections. WIREs Syst Biol Med. 2019. Link
Site last updated: Sep-25-2020