PUBLICATIONS

2024

Garikapati K, Young IC, Hong S, Rai P, Jain C, Briegel KJ. Blocking LBH expression causes replication stress and sensitizes triple-negative breast cancer cells to ATR inhibitor treatment. Oncogene. 2024 Jan 31;. doi: 10.1038/s41388-024-02951-3. [Epub ahead of print] PubMed PMID: 38297083. 

2023

Zhang L, Troccoli CI, Mateo-Victoriano B, Lincheta LM, Jackson E, Shu P, Plastini T, Tao W, Kwon D, Chen X, Sharma J, Jorda M, Gulley JL, Bilusic M, Lockhart AC, Beuve A, Rai P. The soluble guanylyl cyclase pathway is inhibited to evade androgen deprivation-induced senescence and enable progression to castration resistance. bioRxiv. 2023 May 3;. doi: 10.1101/2023.05.03.537252. PubMed PMID: 37205442; PubMed Central PMCID: PMC10187243.
(Pre-print, currently under revision)

2021

Liu J, Tao X, Zhu Y, Li C, Ruan K, Diaz-Perez Z, Rai P, Wang H, Zhai RG. NMNAT promotes glioma growth through regulating post-translational modifications of P53 to inhibit apoptosis. Elife. 2021 Dec 17;10. doi: 10.7554/eLife.70046. PubMed PMID: 34919052; PubMed Central PMCID: PMC8683086. 

2020

Zhang L, Misiara L, Samaranayake GJ, Sharma N, Nguyen DM, Tahara YK, Kool ET, Rai P. OGG1 co-inhibition antagonizes the tumor-inhibitory effects of targeting MTH1. Redox Biol. 2021 Apr;40:101848. doi: 10.1016/j.redox.2020.101848. Epub 2021 Jan 2. PubMed PMID: 33450725; PubMed Central PMCID: PMC7810763.

2019

Samaranayake GJ, Troccoli CI, Zhang L, Huynh M, Jayaraj CJ, Ji D, McPherson L, Onishi Y, Nguyen DM, Robbins DJ, Karbaschi M, Cooke MS, Barrientos A, Kool ET, Rai P. The Existence of MTH1-independent 8-oxodGTPase Activity in Cancer Cells as a Compensatory Mechanism against On-target Effects of MTH1 Inhibitors. Mol Cancer Ther. 2020 Feb;19(2):432-446. doi: 10.1158/1535-7163.MCT-19-0437. Epub 2019 Nov 19. PubMed PMID: 31744893; PubMed Central PMCID: PMC7079300.

*One of STAT News 64 most impactful publications of the year

McPherson LA, Troccoli CI, Ji D, Bowles AE, Gardiner ML, Mohsen MG, Nagathihalli NS, Nguyen DM, Robbins DJ, Merchant NB, Kool ET, Rai P, Ford JM. Increased MTH1-specific 8-oxodGTPase activity is a hallmark of cancer in colon, lung and pancreatic tissue. DNA Repair (Amst). 2019 Nov;83:102644. doi: 10.1016/j.dnarep.2019.102644. Epub 2019 Jul 5. PubMed PMID: 31311767; PubMed Central PMCID: PMC7390602.

Zhu Y, Liu J, Park J, Rai P, Zhai RG. Subcellular compartmentalization of NAD(+) and its role in cancer: A sereNADe of metabolic melodies. Pharmacol Ther. 2019 Aug;200:27-41. doi: 10.1016/j.pharmthera.2019.04.002. Epub 2019 Apr 8. Review. PubMed PMID: 30974124; PubMed Central PMCID: PMC7010080.

Rai P, Sobol RW. Mechanisms of MTH1 inhibition-induced DNA strand breaks: The slippery slope from the oxidized nucleotide pool to genotoxic damage. DNA Repair (Amst). 2019 May;77:18-26. doi: 10.1016/j.dnarep.2019.03.001. Epub 2019 Mar 2. Review. PubMed PMID: 30852368; PubMed Central PMCID: PMC6478497.

2018

Nagathihalli NS, Castellanos JA, Lamichhane P, Messaggio F, Shi C, Dai X, Rai P, Chen X, VanSaun MN, Merchant NB. Inverse Correlation of STAT3 and MEK Signaling Mediates Resistance to RAS Pathway Inhibition in Pancreatic Cancer. Cancer Res. 2018 Nov 1;78(21):6235-6246. doi: 10.1158/0008-5472.CAN-18-0634. Epub 2018 Aug 28. PubMed PMID: 30154150; PubMed Central PMCID: PMC6878978. 

Bhat AA, Lu H, Soutto M, Capobianco A, Rai P, Zaika A, El-Rifai W. Exposure of Barrett's and esophageal adenocarcinoma cells to bile acids activates EGFR-STAT3 signaling axis via induction of APE1. Oncogene. 2018 Nov;37(46):6011-6024. doi: 10.1038/s41388-018-0388-8. Epub 2018 Jul 10. PubMed PMID: 29991802; PubMed Central PMCID: PMC6328352. 

2017

Rodriguez-Blanco J, Pednekar L, Penas C, Li B, Martin V, Long J, Lee E, Weiss WA, Rodriguez C, Mehrdad N, Nguyen DM, Ayad NG, Rai P, Capobianco AJ, Robbins DJ. Inhibition of WNT signaling attenuates self-renewal of SHH-subgroup medulloblastoma. Oncogene. 2017 Nov 9;36(45):6306-6314. doi: 10.1038/onc.2017.232. Epub 2017 Jul 17. PubMed PMID: 28714964; PubMed Central PMCID: PMC5680121. 

Samaranayake GJ, Troccoli CI, Huynh M, Lyles RDZ, Kage K, Win A, Lakshmanan V, Kwon D, Ban Y, Chen SX, Zarco ER, Jorda M, Burnstein KL, Rai P. Thioredoxin-1 protects against androgen receptor-induced redox vulnerability in castration-resistant prostate cancer. Nat Commun. 2017 Oct 31;8(1):1204. doi: 10.1038/s41467-017-01269-x. PubMed PMID: 29089489; PubMed Central PMCID: PMC5663934. 

Samaranayake GJ, Huynh M, Rai P. MTH1 as a Chemotherapeutic Target: The Elephant in the Room. Cancers (Basel). 2017 May 8;9(5). doi: 10.3390/cancers9050047. Review. PubMed PMID: 28481306; PubMed Central PMCID: PMC5447957. 

2016

Li B, Giambelli C, Tang B, Winterbottom E, Long J, Jin K, Wang Z, Fei DL, Nguyen DM, Athar M, Wang B, Subbarayan PR, Wang L, Rai P, Ardalan B, Capobianco AJ, Robbins DJ. Arsenic Attenuates GLI Signaling, Increasing or Decreasing its Transcriptional Program in a Context-Dependent Manner. Mol Pharmacol. 2016 Feb;89(2):226-32. doi: 10.1124/mol.115.100867. Epub 2015 Nov 16. PubMed PMID: 26573582; PubMed Central PMCID: PMC4727125.

Rice MA, Ishteiwy RA, Magani F, Udayakumar T, Reiner T, Yates TJ, Miller P, Perez-Stable C, Rai P, Verdun R, Dykxhoorn DM, Burnstein KL. The microRNA-23b/-27b cluster suppresses prostate cancer metastasis via Huntingtin-interacting protein 1-related. Oncogene. 2016 Sep 8;35(36):4752-61. doi: 10.1038/onc.2016.6. Epub 2016 Feb 22. PubMed PMID: 26898757; PubMed Central PMCID: PMC5770234. 

Marks V, Munoz A, Rai P, Walls JD. (1)H NMR studies distinguish the water soluble metabolomic profiles of untransformed and RAS-transformed cells. PeerJ. 2016;4:e2104. doi: 10.7717/peerj.2104. eCollection 2016. PubMed PMID: 27330862; PubMed Central PMCID: PMC4906648. 

2015

Burton DG, Rai P. MTH1 counteracts oncogenic oxidative stress. Oncoscience. 2015;2(10):785-6. doi: 10.18632/oncoscience.240. eCollection 2015. PubMed PMID: 26682244; PubMed Central PMCID: PMC4671919.

Reiner T, de Las Pozas A, Parrondo R, Palenzuela D, Cayuso W, Rai P, Perez-Stable C. Mcl-1 protects prostate cancer cells from cell death mediated by chemotherapy-induced DNA damage. Oncoscience. 2015;2(8):703-15. doi: 10.18632/oncoscience.231. eCollection 2015. PubMed PMID: 26425662; PubMed Central PMCID: PMC4580064.

Giribaldi MG, Munoz A, Halvorsen K, Patel A, Rai P. MTH1 expression is required for effective transformation by oncogenic HRAS. Oncotarget. 2015 May 10;6(13):11519-29. doi: 10.18632/oncotarget.3447. PubMed PMID: 25893378; PubMed Central PMCID: PMC4484473. 

2014

Patel A, Burton DG, Halvorsen K, Balkan W, Reiner T, Perez-Stable C, Cohen A, Munoz A, Giribaldi MG, Singh S, Robbins DJ, Nguyen DM, Rai P. MutT Homolog 1 (MTH1) maintains multiple KRAS-driven pro-malignant pathways. Oncogene. 2015 May 14;34(20):2586-96. doi: 10.1038/onc.2014.195. Epub 2014 Jul 14. PubMed PMID: 25023700; PubMed Central PMCID: PMC4294948. 

2013

Burton DG, Giribaldi MG, Munoz A, Halvorsen K, Patel A, Jorda M, Perez-Stable C, Rai P. Androgen deprivation-induced senescence promotes outgrowth of androgen-refractory prostate cancer cells. PLoS One. 2013;8(6):e68003. doi: 10.1371/journal.pone.0068003. Print 2013. PubMed PMID: 23840802; PubMed Central PMCID: PMC3695935.

2012

Rai P. Human Mut T Homolog 1 (MTH1): a roadblock for the tumor-suppressive effects of oncogenic RAS-induced ROS. Small GTPases. 2012 Apr-Jun;3(2):120-5. doi: 10.4161/sgtp.19556. PubMed PMID: 22790201; PubMed Central PMCID: PMC3408976.

Patel A, Muñoz A, Halvorsen K, Rai P. Creation and validation of a ligation-independent cloning (LIC) retroviral vector for stable gene transduction in mammalian cells. BMC Biotechnol. 2012 Jan 16;12:3. doi: 10.1186/1472-6750-12-3. PubMed PMID: 22248071; PubMed Central PMCID: PMC3298557. 

2011

Rai P, Young JJ, Burton DG, Giribaldi MG, Onder TT, Weinberg RA. Enhanced elimination of oxidized guanine nucleotides inhibits oncogenic RAS-induced DNA damage and premature senescence. Oncogene. 2011 Mar 24;30(12):1489-96. doi: 10.1038/onc.2010.520. Epub 2010 Nov 15. PubMed PMID: 21076467.

2010

Rai P. Oxidation in the nucleotide pool, the DNA damage response and cellular senescence: Defective bricks build a defective house. Mutat Res. 2010 Nov 28;703(1):71-81. doi: 10.1016/j.mrgentox.2010.07.010. Epub 2010 Jul 29. Review. PubMed PMID: 20673809.

Parrondo R, de las Pozas A, Reiner T, Rai P, Perez-Stable C. NF-kappaB activation enhances cell death by antimitotic drugs in human prostate cancer cells. Mol Cancer. 2010 Jul 9;9:182. doi: 10.1186/1476-4598-9-182. PubMed PMID: 20618955; PubMed Central PMCID: PMC2908581. 

Young JJ, Patel A, Rai P. Suppression of thioredoxin-1 induces premature senescence in normal human fibroblasts. Biochem Biophys Res Commun. 2010 Feb 12;392(3):363-8. doi: 10.1016/j.bbrc.2010.01.026. Epub 2010 Jan 13. PubMed PMID: 20074557. 

2009

Rai P, Onder TT, Young JJ, McFaline JL, Pang B, Dedon PC, Weinberg RA. Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence. Proc Natl Acad Sci U S A. 2009 Jan 6;106(1):169-74. doi: 10.1073/pnas.0809834106. Epub 2008 Dec 31. PubMed PMID: 19118192; PubMed Central PMCID: PMC2629241.