2026

Lee JH, Song H, Yoo EJ, Jeong Y, Ko SM, Shin GW, Choi GE, Jee Y, Kang M, Yang J, Hur SP, Park JE, Lee Y, Park HK, Yun JH, Jang MK, Lee-Kwon W, Kwon HM, Choi SY. Hepatocyte TonEBP promotes metabolic stress-induced hepatic fibroinflammation involving transcriptional activation of ELR⁺ CXC chemokines. Cell Death Discov. 2026 Feb 26;12(1):116. PubMed PMID: 41748547  

2025

Kawasaki K, Salehi S, Zhan Y, Chen K, Lee JH, Salataj E, Zhong H, Manoj P, Kinyua D, Mello BP, Sridhar H, Tischfield SE, Linkov I, Ceglia N, Zatzman M, Havasov E, Shah N, Meng F, Loomis B, Bhanot UK, Redin E, Stanchina E, Hamard P-J, Koche RP, McPherson A, Quintanal-Villalonga A, Shah SP, Massagué J, Rudin CM. FOXA2 promotes metastatic competence in small cell lung cancer. Nat. Commun. 2025 May 26;16(1):4865. PubMed PMID: 40419484 

2024

Lee JH, Sánchez-Rivera F, He L, Basnet H, Chen FX, Spina E, Li L, Torner C, Chan JE, Yarlagadda DVK, Park JS, Sussman C, Rudin CM, Lowe SW, Tammela T, Macias MJ, Koche RP, Massagué J. TGF-β and RAS jointly unmask primed enhancers to drive metastasis. Cell. 2024;187(22):6182-6199.e29. PubMed PMID: 39243762. 

2022

Lee JH, Massagué J. TGFβ in developmental and fibrogenic EMT. Semin Cancer Biol. 2022 Nov;86(Pt 2):136-145. PubMed PMID: 36183999

2021

Kang HJ#, Cheon NY#, Park H, Jeong GW, Ye BJ, Yoo EJ, Lee JH, Hur J, Kim H, Lee K, Choi SY, Lee-Kwon W, Myung K, Lee JY, Kwon HM. TonEBP recognizes R-loop and initiates m6A RNA methylation for R-loop resolution. Nucleic Acids Res. 2021 Jan 11;49(1):269-284. PubMed PMID: 33313823 

2020

Lee JH, Suh JH, Kang HJ, Choi SY, Jung SW, Lee-Kwon W, Park SA, Kim H, Ye BJ, Yoo EJ, Jeong GW, Park NH, Kwon HM. Tonicity-responsive enhancer-binding protein promotes stemness of liver cancer and cisplatin resistance. EBioMedicine. 2020 Jul 30;58:102926. PubMed PMID: 32739873 

Ye BJ, Lee HH, Yoo EJ, Lee CY, Lee JH, Kang HJ, Jeong GW, Park H, Lee-Kwon W, Choi SY, Kwon HM. TonEBP in dendritic cells mediates pro-inflammatory maturation and Th1/Th17 responses. Cell Death Dis. 2020 Jun 4;11(6):421. PubMed PMID: 32499518 

2019

Lee JH, Suh JH, Choi SY, Kang HJ, Lee HH, Ye BJ, Lee GR, Jung SW, Kim CJ, Lee-Kwon W, Park J, Myung K, Park NH, Kwon HM. Tonicity-responsive enhancer-binding protein promotes hepatocellular carcinogenesis, recurrence and metastasis. Gut. 2019 Feb;68(2):347-358. PubMed PMID: 29420225.

Kang HJ, Park H, Yoo EJ, Lee JH, Choi SY, Lee-Kwon W, Lee KY, Hur JH, Seo JK, Ra JS, Lee EA, Myung K, Kwon HM. TonEBP Regulates PCNA Polyubiquitination in Response to DNA Damage through Interaction with SHPRH and USP1. iScience. 2019 Sep 27;19:177-190. PubMed PMID: 31376680 

Lee HH, An SM, Ye BJ, Lee JH, Yoo EJ, Jeong GW, Kang HJ, Alfadda AA, Lim SW, Park J, Lee-Kwon W, Kim JB, Choi SY, Kwon HM. TonEBP/NFAT5 promotes obesity and insulin resistance by epigenetic suppression of white adipose tissue beiging. Nat Commun. 2019 Aug 6;10(1):3536. PubMed PMID: 31387996 

Yoo EJ, Lee HH, Ye BJ, Lee JH, Lee CY, Kang HJ, Jeong GW, Park H, Lim SW, Lee-Kwon W, Kwon HM, Choi SY. TonEBP Suppresses the HO-1 Gene by Blocking Recruitment of Nrf2 to Its Promoter. Front Immunol. 2019;10:850. PubMed PMID: 31057560 

Lee C#, Kim M#, Lee JH, Oh J, Shin HH, Lee SM, Scherer PE, Kwon HM, Choi JH, Park J. COL6A3-derived endotrophin links reciprocal interactions among hepatic cells in the pathology of chronic liver disease. J Pathol. 2019 Jan;247(1):99-109. PubMed PMID: 30246318 

2018

Choi SY, Lim SW, Salimi S, Yoo EJ, Lee-Kwon W, Lee HH, Lee JH, Mitchell BD, Sanada S, Parsa A, Kwon HM. Tonicity-Responsive Enhancer-Binding Protein Mediates Hyperglycemia-Induced Inflammation and Vascular and Renal Injury. J Am Soc Nephrol. 2018 Feb;29(2):492-504. PubMed PMID: 29158465 

2016

Choi SY, Lee HH, Lee JH, Ye BJ, Yoo EJ, Kang HJ, Jung GW, An SM, Lee-Kwon W, Chiong M, Lavandero S, Kwon HM. TonEBP suppresses IL-10-mediated immunomodulation. Sci Rep. 2016 May 10;6:25726.  PubMed PMID: 27160066 

Lee HH#, Sanada S#, An SM, Ye BJ, Lee JH, Seo YK, Lee C, Lee-Kwon W, Küper C, Neuhofer W, Choi SY, Kwon HM. LPS-induced NFκB enhanceosome requires TonEBP/NFAT5 without DNA binding. Sci Rep. 2016 Apr 27;6:24921. PubMed PMID: 27118681 

2015

Lee JH, Lee HH, Ye BJ, Lee-Kwon W, Choi SY, Kwon HM. TonEBP suppresses adipogenesis and insulin sensitivity by blocking epigenetic transition of PPARγ2. Sci Rep. 2015 Jun 4;5:10937. PubMed PMID: 26042523. 

2013

Choi SY, Lee-Kwon W, Lee HH, Lee JH, Sanada S, Kwon HM. Multiple cell death pathways are independently activated by lethal hypertonicity in renal epithelial cells. Am J Physiol Cell Physiol. 2013 Nov 15;305(10):C1011-20.  PubMed PMID: 23986196