Publications

2025

1. Lee, C.; Kim, K.; Hyun, S.; Hong, S.*; Rhee, I.* Reprogramming Macrophage Polarization with a Small Molecule G3I: Enhancing Tumor Suppression and Inflammation Control Biomed. Pharmacother. 2025, 191:118448. (link)

2. Lee, C.; Hyun, S.; Rhee, I.* Flow Cytometric and Multimodal Detection of ASC Speck Formation in THP-1 Monocytes and Murine Macrophages Following Canonical Inflammasome Activation Journal of Analytical Science and Technology 2025, 16, 34 (link)

2024

1. Jung, C.;  Lee, K.;  Rajasekar, S.;  Yim, J.-Y.;  Sim, J.;  Lee, Y. H.;  Kwak, J.-H.;  Hyun, S.;  Kang, Y. K.;  Viji, M.; Jung, J.-K., Formal [4 + 2] combined ionic and radical approach of vinylogous enaminonitriles to access highly substituted sulfonyl pyridazines. Communications Chemistry 2024, 7 (1), 281. (link)

2. Kang, J. H.; Jeong, J. H.; Kwon, Y. B.; Kim, Y. J.; Shin, D. H.; Park, Y. S.; Hyun, S.; Kim, D. W.; Park, C. W. Mucosal Penetrative Polymeric Micelle Formulations for Insulin Delivery to the Respiratory Tract. Int J Nanomedicine 2024, 19, 9195-9211. (link)

3. Park, J.; Yamashita, E.; Yu, J.; Lee, S. J.; Hyun, S.* De Novo Designed Cell-Penetrating Peptide Self-Assembly Featuring Distinctive Tertiary Structure. ACS Omega 2024. 9, 32991−32999. DOI: 10.1021/acsomega.4c04004. (link)

4.  Kim, S.; Kwak, J.-H.; Jung, J.-K.; Hyun, S.* Method development for 14C-labeling of IgG antibodies in preparation for clinical trials. Journal of Analytical Science and Technology 2024, 15 (1), 6. DOI: 10.1186/s40543-024-00420-w. (link)

5. Jung, Y. J.; Hosseininasab, N.; Park, J.; Hyun, S.; Jung, J.-K.; Kwak, J.-H. Microwave-Promoted Total Synthesis of Puniceloid D for Modulating the Liver X Receptor.  Molecules, 2024, 29, 416. (link)

2023

1.  Shin, G.; Hyun, S.; Kim, D.; Choi, Y.; Kim, K. H.; Kim, D.; Kwon, S.; Kim, Y. S.; Yang, S. H.; Yu, J. Cyclohexylalanine-Containing α-Helical Amphipathic Peptide Targets Cardiolipin, Rescuing Mitochondrial Dysfunction in Kidney Injury. J. Med. Chem. 2023. 67, 3385−3399. DOI: 10.1021/acs.jmedchem.3c01578. (link)

2. Gurung, R.; Om, D.; Pun, R.; Hyun, S.; Shin, D. Recent Progress in Modulation of WD40-Repeat Domain 5 Protein (WDR5): Inhibitors and Degraders. Cancers 2023, 15, 3910. (link)

2022

1. Hyun, S.; Kim, D.; Cho, J.; Jeong, D.; Chung, D.H.; Yu, J. Design and Optimization of an α-Helical Bundle Dimer Cell-Penetrating Peptide for In Vivo Drug Delivery. Bioconjug Chem. 2022, 33 (12), 2420-2427. (link)

2. Chaudhary, C.L.; Ko, S.; Lee, C.; Kim, Y.; Jung, C.; Hyun, S.; Kwon, Y.; Kang, J.-S.; Jung, J.-K.; Lee, H. Design, Synthesis, and Cytotoxicity and Topoisomerase I/IIα Inhibition Activity of Pyrazolo[4,3-f]quinoline Derivatives. Pharmaceuticals 2022, 15, 399. (link)

3. Jung, C.; Li, S.; Lee, K.; Viji, M.; Lee, H.; Hyun, S.; Lee, K.; Kang, Y. K.; Chaudhary, C. L.; Jung, J.-K. Reagent-free intramolecular hydrofunctionalization: a regioselective 6-endo-dig cyclization of o-alkynoylphenols. Green Chem. 2022, 24 (6), 2376-2384. (link)

2021

1. Sim, J.;  Lanka, S.;  Jo, J.-W.;  Chaudhary, C. L.;  Vishwanath, M.;  Jung, C.-H.;  Lee, Y.-H.;  Kim, E.-Y.;  Kim, Y.-S.;  Hyun, S.-S.;  Lee, H.-S.;  Lee, K.;  Seo, S.-Y.;  Viji, M.; Jung, J.-K., Inhibitory Effect of Chlorogenic Acid Analogues Comprising Pyridine and Pyrimidine on α-MSH-Stimulated Melanogenesis and Stability of Acyl Analogues in Methanol. Pharmaceuticals 2021, 14 (11), 1176. (link)

2. Hyun, S.; Shin, D., Small-Molecule Inhibitors and Degraders Targeting KRAS-Driven Cancers. Int. J. Mol. Sci. 2021, 22 (22), 12142. (link)

3. Hyun, S.; Shin, D., Chemical-Mediated Targeted Protein Degradation in Neurodegenerative Diseases. Life 2021, 11 (7), 607. (link)

4. Hyun, S.;  Park, N.;  Nam, S. H.;  Cheon, D. H.;  Lee, Y.;  Lim, H.-S.; Yu, J., One-bead-one-compound screening approach to the identification of cyclic peptoid inhibitors of cyclophilin D as neuroprotective agents from mitochondrial dysfunction. Chem. Commun. 2021, 57 (19), 2388-2391. (link)

5. Nam, S. H.;  Jang, J.;  Cheon, D. H.;  Chong, S.-E.;  Ahn, J. H.;  Hyun, S.;  Yu, J.; Lee, Y., pH-Activatable cell penetrating peptide dimers for potent delivery of anticancer drug to triple-negative breast cancer. J. Control. Release 2021, 330, 898-906. (link)

2020

1. Hyun, S.;  Choi, Y.;  Jo, D.;  Choo, S.;  Park, T. W.;  Park, S.-J.;  Kim, S.;  Lee, S.;  Park, S.;  Jin, S. M.;  Cheon, D. H.;  Yoo, W.;  Arya, R.;  Chong, Y. P.;  Kim, K. K.;  Kim, Y. S.;  Lee, Y.; Yu, J., Proline Hinged Amphipathic α-Helical Peptide Sensitizes Gram-Negative Bacteria to Various Gram-Positive Antibiotics. J. Med. Chem. 2020, 63 (23), 14937-14950. (link)

2011-2019

1. Hyun, S.;  Li, L.;  Yoon, K. C.; Yu, J., An amphipathic cell penetrating peptide aids cell penetration of cyclosporin A and increases its therapeutic effect in an in vivo mouse model for dry eye disease. Chem. Commun. 2019, 55, 13657-13660. (link) 

2. Oh, J. H.;  Chong, S.-E.;  Nam, S.;  Hyun, S.;  Choi, S.;  Gye, H.;  Jang, S.;  Jang, J.;  Hwang, S. W.;  Yu, J.; Lee, Y., Multimeric Amphipathic α-Helical Sequences for Rapid and Efficient Intracellular Protein Transport at Nanomolar Concentrations. Advanced Science 2018, 5 (8), 1800240. (link)

3. Kim, G. C.;  Ahn, J. H.;  Oh, J. H.;  Nam, S.;  Hyun, S.;  Yu, J.; Lee, Y., Photoswitching of Cell Penetration of Amphipathic Peptides by Control of α-Helical Conformation. Biomacromolecules 2018, 19 (7), 2863-2869. (link)

4. Hyun, S.;  Lee, Y.;  Jin, S. M.;  Cho, J.;  Park, J.;  Hyeon, C.;  Kim, K.-S.;  Lee, Y.; Yu, J., Oligomer Formation Propensities of Dimeric Bundle Peptides Correlate with Cell Penetration Abilities. ACS Central Science 2018, 4 (7), 885-893. (link)

5. Hyun, S.;  Choi, Y.;  Lee, H. N.;  Lee, C.;  Oh, D.;  Lee, D.-K.;  Lee, C.;  Lee, Y.; Yu, J., Construction of histidine-containing hydrocarbon stapled cell penetrating peptides for in vitro and in vivo delivery of siRNAs. Chem. Sci. 2018, 9 (15), 3820-3827. (link)

6. Pai, J.;  Hyun, S.;  Hyun, J. Y.;  Park, S.-H.;  Kim, W.-J.;  Bae, S.-H.;  Kim, N.-K.;  Yu, J.; Shin, I., Screening of pre-miRNA-155 Binding Peptides for Apoptosis Inducing Activity Using Peptide Microarrays. J. Am. Chem. Soc. 2016, 138 (3), 857-867. (link)

7. Kim, S.;  Hyun, S.;  Lee, Y.;  Yu, J.; Lee, Y., Nonhemolytic Cell-Penetrating Peptides: Site Specific Introduction of Glutamine and Lysine Residues into the α-Helical Peptide Causes Deletion of Its Direct Membrane Disrupting Ability but Retention of Its Cell Penetrating Ability. Biomacromolecules 2016, 17 (9), 3007-15. (link)

8. Lee, J.;  Jung, J.;  Tak, M. H.;  Wee, J.;  Lee, B.;  Jang, Y.;  Chun, H.;  Yang, D.-J.;  Yang, Y. D.;  Park, S. H.;  Han, B. W.;  Hyun, S.;  Yu, J.;  Cho, H.;  Hartzell, H. C.; Oh, U., Two helices in the third intracellular loop determine anoctamin 1 (TMEM16A) activation by calcium. Pflugers Arch 2015, 467 (8), 1677-87. (link)

9. Jang, S.;  Hyun, S.;  Kim, S.;  Lee, S.;  Lee, I.-S.;  Baba, M.;  Lee, Y.; Yu, J., Cell-Penetrating, Dimeric α-Helical Peptides: Nanomolar Inhibitors of HIV-1 Transcription. Angew. Chem., Int. Ed. 2014, 53 (38), 10086-10089. (link)

10. Hyun, S.;  Lee, S.;  Kim, S.;  Jang, S.;  Yu, J.; Lee, Y., Apoptosis Inducing, Conformationally Constrained, Dimeric Peptide Analogs of KLA with Submicromolar Cell Penetrating Abilities. Biomacromolecules 2014, 15 (10), 3746-3752. (link)

11. Hyun, S.;  Han, A.;  Jo, M. H.;  Hohng, S.; Yu, J., Dicer Nuclease-Promoted Production of Let7a-1 MicroRNA Is Enhanced in the Presence of Tryptophan-Containing Amphiphilic Peptides. Chembiochem : a European journal of chemical biology 2014, 15 (11), 1651-1659. (link)

12. Son, M.;  Lee, Y.;  Hwang, H.;  Hyun, S.; Yu, J., Disruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of α-helical amphipathic peptides. ChemMedChem 2013, 8 (10), 1638-42. (link)

13. Hwang, H.;  Hyun, S.;  Kim, Y.; Yu, J., Reduction of Helical Content by Insertion of a Disulfide Bond Leads to an Antimicrobial Peptide with Decreased Hemolytic Activity. ChemMedChem 2013, 8 (1), 59-62. (link)

14. Kim, I.;  Kwak, H.;  Lee, H. K.;  Hyun, S.; Jeong, S., β-Catenin recognizes a specific RNA motif in the cyclooxygenase-2 mRNA 3'-UTR and interacts with HuR in colon cancer cells. Nucleic Acids Res. 2012, 40 (14), 6863-6872. (link)

15. Park, S.;  Hyun, S.;  Do, S.-i.; Yu, J., Selective α-glucosidase substrates and inhibitors containing short aromatic peptidyl moieties. Bioorg. Med. Chem. Lett. 2011, 21 (8), 2441-2444. (link)

16. Hyun, S.;  Lee, K. H.;  Han, A.; Yu, J., An RNA aptamer that selectively recognizes symmetric dimethylation of arginine 8 in the histone H3 N-terminal peptide. Nucleic Acid Ther. 2011, 21 (3), 157-163. (link)

17. Han, A.;  Lee, K. H.;  Hyun, S.;  Lee, N. J.;  Lee, S. J.;  Hwang, H.; Yu, J., Methylation-mediated control of Aurora kinase B and haspin with epigenetically modified histone H3 N-terminal peptides. Bioorg. Med. Chem. 2011, 19 (7), 2373-2377. (link)

Before 2010

1. Hyun, S.;  Na, J.;  Lee, S. J.;  Park, S.; Yu, J., RNA Grooves Can Accommodate Disulfide-Bridged Bundles of α-Helical Peptides. Chembiochem 2010, 11 (6), 767-770. (link)

2. Cho, S. C.;  Park, M. C.;  Keam, B.;  Choi, J. M.;  Cho, Y.;  Hyun, S.;  Park, S. C.; Lee, J., DDS, 4,4'-diaminodiphenylsulfone, extends organismic lifespan. Proc. Natl. Acad. Sci. 2010, 107 (45), 19326-19331. (link)

3. Lee, S. J.;  Hyun, S.;  Kieft, J. S.; Yu, J., An Approach to the Construction of Tailor-Made Amphiphilic Peptides That Strongly and Selectively Bind to Hairpin RNA Targets. J. Am. Chem. Soc. 2009, 131 (6), 2224-2230. (link)

4. Lee, K. H.;  Lee, N. J.;  Hyun, S.;  Park, Y. K.;  Yang, E. G.;  Lee, J.-K.;  Jeong, S.; Yu, J., Histone H3 N-Terminal Peptide Binds Directly to Its Own mRNA: A Possible Mode of Feedback Inhibition to Control Translation. Chembiochem 2009, 10 (8), 1313-1316. (link)

5. Hyun, S.;  Han, A.; Yu, J., Photocrosslinking of RNA and PhotoMet-Containing Amphiphilic α-Helical Peptides. Chembiochem 2009, 10 (6), 987-989. (link)

6. Lee, Y.;  Hyun, S.;  Kim, H. J.; Yu, J., Amphiphilic helical peptides containing two acridine moieties display picomolar affinity toward HIV-1 RRE and TAR. Angew. Chem., Int. Ed. 2008, 47 (1), 134-137. (link)

7. Hyun, S.;  Lee, E. H.;  Park, J.; Yu, J., Tentacle type peptides as artificial lectins against sulfated Lewis X and A. Bioorg. Med. Chem. Lett. 2008, 18 (14), 4011-4014. (link)

8. Hyun, S.;  Jeong, S.; Yu, J., Effects of asymmetric arginine dimethylation on RNA-binding peptides. Chembiochem 2008, 9 (17), 2790-2792. (link)

9. Hyun, S.;  Kim, J.;  Kwon, M.; Yu, J., Selection and syntheses of tentacle type peptides as 'artificial' lectins against various cell-surface carbohydrates. Bioorg. Med. Chem. 2007, 15 (1), 511-517. (link)

10. Hyun, S.;  Kim, H. J.;  Lee, N. J.;  Lee, K. H.;  Lee, Y.;  Ahn, D. R.;  Kim, K.;  Jeong, S.; Yu, J., α-Helical Peptide Containing N,N-Dimethyl Lysine Residues Displays Low-Nanomolar and Highly Specific Binding to RRE RNA. J. Am. Chem. Soc. 2007, 129 (15), 4514-4515. (link)

11. Hyun, S.;  Lee, K. H.; Yu, J., A strategy for the design of selective RNA binding agents. Preparation and RRE RNA binding affinities of a neomycin-peptide nucleic acid heteroconjugate library. Bioorg. Med. Chem. Lett. 2006, 16 (18), 4757-4759. (link)

12. Lee, J.;  Kwon, M.;  Lee, K. H.;  Jeong, S.;  Hyun, S.;  Shin, K. J.; Yu, J., An approach To enhance specificity against RNA targets using heteroconjugates of aminoglycosides and chloramphenicol (or linezolid). J. Am. Chem. Soc. 2004, 126 (7), 1956-1957. (link)

13. Shin, D. Y.;  Kim, H. S.;  Min, K. H.;  Hyun, S. S.;  Kim, S. A.;  Huh, H.;  Choi, E. C.;  Choi, Y. H.;  Kim, J.;  Choi, S. H.;  Kim, W. B.; Suh, Y. G., Isolation of a potent anti-MRSA sesquiterpenoid quinone from Ulmus davidiana var. japonica. Chemical & pharmaceutical bulletin 2000, 48 (11), 1805-6. (link)

14. Shin, D. Y.;  Ryu, J. S.;  Hyun, S. S.;  Park, H. J.;  Jeon, R. O.; Suh, Y. G., Total synthesis of sufentanil. Archives of pharmacal research 1999, 22 (4), 398-400.  (link)