We pioneered Patient Assistance Programs in 1987. Today, NORD programs include free drug, co-pay and premium assistance, travel/lodging assistance for clinical trials, expanded or emergency access, and more.

OPDIVO (nivolumab), in combination with YERVOY (ipilimumab), is indicated for the treatment of adult patients with hepatocellular carcinoma (HCC) who have been previously treated with sorafenib. This indication is approved under accelerated approval based on overall response rate and duration of response. Continued approval for this indication may be contingent upon verification and description of clinical benefit in the confirmatory trials.

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OPDIVO (nivolumab), in combination with YERVOY (ipilimumab), is indicated for the treatment of adults and pediatric patients 12 years and older with microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) metastatic colorectal cancer (CRC) that has progressed following treatment with a fluoropyrimidine, oxaliplatin, and irinotecan. This indication is approved under accelerated approval based on overall response rate and duration of response. Continued approval for this indication may be contingent upon verification and description of clinical benefit in confirmatory trials.

OPDIVO, as a single agent, is indicated for the treatment of adult and pediatric (12 years and older) patients with microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) metastatic colorectal cancer (CRC) that has progressed following treatment with a fluoropyrimidine, oxaliplatin, and irinotecan. This indication is approved under accelerated approval based on overall response rate and duration of response. Continued approval for this indication may be contingent upon verification and description of clinical benefit in confirmatory trials.

OPDIVO (nivolumab) is indicated for the treatment of adult patients with classical Hodgkin lymphoma (cHL) that has relapsed or progressed after autologous hematopoietic stem cell transplantation (HSCT) and brentuximab vedotin or after 3 or more lines of systemic therapy that includes autologous HSCT. This indication is approved under accelerated approval based on overall response rate. Continued approval for this indication may be contingent upon verification and description of clinical benefit in confirmatory trials.

In addition to the immune-mediated adverse reactions listed above, across clinical trials of YERVOY monotherapy or in combination with OPDIVO, the following clinically significant immune-mediated adverse reactions, some with fatal outcome, occurred in

In randomized clinical trials in patients with multiple myeloma, the addition of OPDIVO to a thalidomide analogue plus dexamethasone resulted in increased mortality. Treatment of patients with multiple myeloma with a PD-1 or PD-L1 blocking antibody in combination with a thalidomide analogue plus dexamethasone is not recommended outside of controlled clinical trials.

The primary concept of this scoping review is Ae. aegypti and Ae. albopictus prevention and control interventions, including (i) insecticide-treated materials (e.g., curtains, nets or screens), (ii) usage of larvicides in breeding sites, (iii) usage of adulticides (e.g., outdoor fogging and indoor residual spraying), (iv) lethal oviposition trap-based mass interventions, (v) container management/reduction, (vi) health education, (vii) community engagement, (viii) media campaigns, (ix) biological control measures (e.g., usages of other living organisms, such as larvivorous fish and Wolbachia), (x) mosquito coils/ repellents, (xi) interventions focussed on behavioural change, advocacy (informed influence activities on policymakers from civil society), and (xii) integrated surveillance, epidemiological or entomological surveillance as part of a control program. All field experiments that were not population-based simulations or semi-field trials were excluded. 589ccfa754

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