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Modulation of Post-Translational Modification

• We use small molecules to modulate post-translational modifications (PTMs) on target proteins, including ubiquitination.

New chemical modality to degrade target protein

• We take inspiration from endogenous enzymes and develop novel chemical modalities to degrade the covalent bonds of proteins.

Medicinal Chemistry

• We find more druggable compounds through molecular design, modeling, and optimization.