Featured Research

Non-Invasive Assessment of Isocitrate Dehydrogenase-Mutant Gliomas Using Optimized Proton Magnetic Resonance Spectroscopy on a Routine Clinical 3-Tesla MRI - PubMedNoninvasive optimized <sup>1</sup>H-MRS may be useful in predicting <i>IDH</i> mutational status and 2HG may serve as a valuable diagnostic and prognostic biomarker in patients with gliomas.

Taming Glioblastoma in "Real Time": Integrating Multimodal Advanced Neuroimaging/AI Tools Towards Creating a Robust and Therapy Agnostic Model for Response Assessment in Neuro-Oncology - PubMedThe highly aggressive nature of glioblastoma carries a dismal prognosis despite aggressive multimodal therapy. Alternative treatment regimens, such as immunotherapies, are known to intensify the inflammatory response in the treatment field. Follow-up imaging in these scenarios often mimics disease p …

Assessment of treatment response to dendritic cell vaccine in patients with glioblastoma using a multiparametric MRI-based prediction model - PubMedMultiparametric MRI-based prediction model can assess treatment response to DCVax-L in patients with glioblastoma.

Validation of multiparametric MRI based prediction model in identification of pseudoprogression in glioblastomas - PubMedOur multiparametric MRI based prediction model may be helpful in identifying PsP in GBM patients.

MRI-Based Radiomics Combined with Deep Learning for Distinguishing IDH-Mutant WHO Grade 4 Astrocytomas from IDH-Wild-Type GlioblastomasTo differentiate IDH-mutant grade 4 astrocytomas from IDH-wild-type glioblastomas, two MRI sequences (post-contrast T1 and T2-FLAIR) were acquired from 57 patients. The images were resliced, resampled, and realigned. In the next step, tumors were ...

Prognostication of overall survival in patients with brain metastases using diffusion tensor imaging and dynamic susceptibility contrast-enhanced MRITo investigate the prognostic utility of DTI and DSC-PWI perfusion-derived parameters in brain metastases patients. Retrospective analyses of DTI-derived parameters (MD, FA, CL, CP, and CS) and DSC-perfusion PWI-derived rCBVmax from 101 patients ...

Multiparametric MRI assessment of response to convection-enhanced intratumoral delivery of MDNA55, an interleukin-4 receptor targeted immunotherapy, for recurrent glioblastomaGlioblastoma (GBM) is the most common malignant brain tumor and carries a dismal prognosis. Attempts to develop biologically targeted therapies are challenging as the blood–brain barrier can limit drugs from reaching their target when administered ...

Lack of choline elevation on proton magnetic resonance spectroscopy in grade I-III gliomas - PubMedElevated levels of choline are generally emphasized as marker of increased cellularity and cell membrane turnover in gliomas. In this study, we investigated the incidence rate of lack of choline/creatine and choline/water elevation in a population of grade I-III gliomas. A cohort of 41 patients with …

Detection of occult neoplastic infiltration in the corpus callosum and prediction of overall survival in patients with glioblastoma using diffusion tensor imaging - PubMedFA values from the CC can quantify occult tumor infiltration and serve as a sensitive prognostic marker for prediction of overall survival in GBM patients.

Differentiating Tumor Progression from Pseudoprogression in Patients with Glioblastomas Using Diffusion Tensor Imaging and Dynamic Susceptibility Contrast MRI - PubMedDTI and DSC perfusion imaging can improve accuracy in assessing treatment response and may aid in individualized treatment of patients with glioblastomas.

Multiparametric magnetic resonance imaging in the assessment of anti-EGFRvIII chimeric antigen receptor T cell therapy in patients with recurrent glioblastoma - PubMedEGFRvIII targeted chimeric antigen receptor T (CAR-T) cell therapy has recently been reported for treating glioblastomas (GBMs); however, physiology-based MRI parameters have not been evaluated in this setting. Ten patients underwent multiparametric MRI at baseline, 1, 2 and 3 months after CAR-T the …

Differentiation of brain infection from necrotic glioblastoma using combined analysis of diffusion and perfusion MRI - PubMed1 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;49:184-194.

Assessment of early response to tumor-treating fields in newly diagnosed glioblastoma using physiologic and metabolic MRI: initial experienceTumor-treating fields (TTFields) is a novel antimitotic treatment modality for patients with glioblastoma. To assess response to TTFields, a newly diagnosed patient with glioblastoma underwent diffusion, perfusion and 3D echo-planar spectroscopic ...

Radiation injury to the normal brain measured by 3D-echo-planar spectroscopic imaging and diffusion tensor imaging: initial experience - PubMedOur preliminary findings suggest that 3D-EPSI and DTI may provide quantitative measures of radiation induced injury to the normal brain.

LL de Godoy, KC Lim, A Rajan, G Verma, M Hanaoka, DM O’Rourke, JYK Lee, A Desai, S Chawla*, S Mohan. Non-Invasive Assessment of Isocitrate Dehydrogenase-Mutant Gliomas Using Optimized Proton Magnetic Resonance Spectroscopy on a Routine Clinical 3-Tesla MRI. Cancers (Basel). 2023;15(18):4453.

LL de Godoy; S Chawla; S Brem; S Mohan. Taming Glioblastoma in ‘Real Time’: Integrating Multimodal Advanced Neuroimaging/AI Tools Towards Creating a Robust and Therapy Agnostic Model for Response Assessment in Neuro-Oncology. ClinCancer Res. 2023;29(14):2588-2592.

LL de Godoy; S Chawla; S Brem; S Wang; DM O’Rourke; MP Nasrallah; A Desai; LA Loevner; LM Liau; S Mohan. Assessment of Treatment Response to Dendritic Cell Vaccine in Patients with Glioblastoma using a Multiparametric MRI-Based Prediction Model. J Neurooncol. 2023;163:173-183.

LL de Godoy, S Mohan, S Wang, MP Nasrallah, Y Sakai, DM O’Rourke, S zBagley, A Desai, LA. Loevner, H Poptani, S Chawla. Validation of Multiparametric MRI Based Prediction Model in Identification of Pseudoprogression in Glioblastomas. J Trans Med. 2023 Apr 28;21(1):287.

SA Hosseini, E Hosseini, G Hajianfar, I Shiri, S Servaes, P Rosa-Neto, L Godoy, MP Nasrallah, DM O'Rourke , S Mohan , S Chawla. MRI-Based Radiomics Combined with Deep Learning for Distinguishing IDH-Mutant WHO Grade 4 Astrocytomas from IDH-Wild-Type Glioblastomas. Cancers (Basel). 2023;15(3):951.

LL de Godoy, YJ Chen, S Chawla, AN Viaene, S Wang, LA Loevner, M Alonso-Basanta, H Poptani, S Mohan. Prognostication of overall survival in patients with brain metastases using diffusion tensor imaging and dynamic susceptibility contrast-enhanced MRI. Br J Radiol. 2022 Dec 1;95(1140):20220516.

S Mohan, S Wang, S Chawla, K Abdullah, A Desai, E Maloney, S Brem. Multiparametric MRI Assessment of Response to Convection-Enhanced Intratumoral Delivery of MDNA55, an Interleukin-4 Receptor Targeted Immunotherapy, for Recurrent Glioblastoma. Surg Neurol Int. 2021 Jul 6;12:337.

S Chawla, SC Lee , S Mohan , S Wang , M Nasrallah , A Vossough , J Krejza , ER Melhem , SA Nabavizadeh. Lack of choline elevation on proton magnetic resonance spectroscopy in grade I-III gliomas. Neuroradiol J. 2019; 32:250-258.

S Mohan; S Wang; G Coban; F Kural; S Chawla; DM O'Rourke; H Poptani. Detection of Occult Neoplastic Infiltration in the Corpus Callosum and Prediction of Overall Survival in Patients with Glioblastoma using Diffusion Tensor Imaging. Eur J Radiol. 2019;112:106-111.

G Verma, S Chawla, S Mohan, S Wang, M Nasrallah, S Sheriff, A Desai, S Brem, DM O’Rourke, R Wolf, A Maudsley, H Poptani. Differentiation of True Progression from Pseudoprogression in Patients with Glioblastoma using Whole Brain Echo-planar Spectroscopic Imaging. NMR Biomed. 2019 Feb;32(2):e4042.

S Wang, DM O'Rourke, S Chawla, et al. Multiparametric magnetic resonance imaging in the assessment of anti-EGFRvIII chimeric antigen receptor T cell therapy in patients with recurrent glioblastoma. Br J Cancer. 2019 Jan;120(1):54-56.

S Chawla, S Wang, S Mohan, MacLean Nasrallah, Gaurav Verma, Steven Brem, Donald M. O’Rourke, Ronald L. Wolf, Harish Poptani, S. Ali Nabavizadeh. Differentiation of brain infection from necrotic glioblastoma using combined analysis of diffusion and perfusion MRI. J Magn Reson Imaging. 2019 Jan;49(1):184-194.

S Mohan, S Chawla, S Wang, G Verma, A Skolnik, S Brem, KB Peters, H Poptani. Assessment of Early Response to Tumor Treating Fields in Newly Diagnosed Glioblastoma using Physiologic and Metabolic MR Imaging: Initial experience. CNS Oncol. 5(3):137-44; 2016.

S Chawla, S Wang, S Kim, S Sheriff, P Lee, R Rengan, A Lin, ER Melhem, A Maudsley, H Poptani. Radiation Injury to the Normal Brain Measured by 3D-Echo-Planar Spectroscopic Imaging and Diffusion Tensor Imaging: Initial Experience. J Neuroimaging. 25(1):97-104;2015.

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