The vasculature is composed of specialized endothelial cells that not only facilitate the exchange of oxygen and nutrient delivery, but is also the site of immune cell trafficking, underscoring its importance in disease pathophysiology. Post-capillary venules (PCVs) are a specialized type of venular endothelial cell that facilitate extravasation through binding of cell surface receptors, addressins, to their ligand on the immune cells. 

The Dinh lab’s long-term goal is to systemically delineate the transcriptional cues that dictate vascular segmentation, specifically venules, and how they change under inflammation. We hope to ultimately uncover insights that could transform our approach to inflammatory diseases and vascular pathologies.