Clinical studies demonstrate the efficacy of Cleaner Smile in removing stains from coffee, tea, tobacco, and aging.

Clinical tests demonstrated that "bleaching is effective in removing the majority of stains brought on by age, tobacco, coffee, and tea." Based on clinical studies, 96% of patients with these kinds of stains experience some lightening effect. Other types of stains, such as those produced by tetracycline use or fluorosis (too much fluoride), respond to bleaching less reliably.