Solid State Logic was recognized for Outstanding Technical Achievement during the 38thAnnual TEC Awards, held on April 13th at the Anaheim Convention Center in California. ORIGIN, SSL's 32-channel in-line analogue mixing console, captured the top spot in Console Technology, while THE BUS+ won in the highly competitive category of Signal Processing Hardware.
Now in its 38th year, the TEC Awards are widely regarded as the highest honour dedicated to the pro audio and sound recording industry, recognizing outstanding performance by the individuals, companies and technical innovations behind the sound of recordings, live performances, films, television, video games and multimedia.
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Phil Wagner, North American Senior Vice President of SSL, commented: SSL is pleased to have ORIGIN and THE BUS+ recognized for Outstanding Technical Achievement, in continuation of our long legacy of innovation. In particular, we are grateful to our customers, who continue to push our technology to the limits in a variety of applications, and to our highly skilled and passionate staff and partners around the world."
The book offers a very large body of activities, each of which provides suggested ways for student to use tech within the context of their subject area learning. And it offers info and suggestions about how to use the tech easily and effectively.
First, I want to point out that our research in preparing the book took us to the work of CASEL (The Collaborative for Academic, Social, and Emotional Learning ), an organization that is acknowledged as establishing the foundation for SEL, providing theory and a framework through which to understand it.
And so, Michele and I reached out to our networks of colleagues for contributions of activities from their classrooms and imaginations, and understandings of what creates high value in teaching and learning. We received suggestions from a group of highly diverse and accomplished educators. And, we expanded this body of work with original activities of our own. Both of us, by the way, have a long history as both teachers and curriculum writers. Having said that, here are just a few of the activities in the book along with a brief description of the associated student content product:
Genome editing is a method that lets scientists change the DNA of many organisms, including plants, bacteria, and animals. Editing DNA can lead to changes in physical traits, like eye color, and disease risk. Scientists use different technologies to do this.
Genome editing technologies enable scientists to make changes to DNA, leading to changes in physical traits, like eye color, and disease risk. Scientists use different technologies to do this. These technologies act like scissors, cutting the DNA at a specific spot. Then scientists can remove, add, or replace the DNA where it was cut.
The first genome editing technologies were developed in the late 1900s. More recently, a new genome editing tool called CRISPR, invented in 2009, has made it easier than ever to edit DNA. CRISPR is simpler, faster, cheaper, and more accurate than older genome editing methods. Many scientists who perform genome editing now use CRISPR.
One way that scientists use genome editing is to investigate different diseases that affect humans. They edit the genomes of animals, like mice and zebrafish, because animals have many of the same genes as humans. For example, mice and humans share about 85 percent of their genes! By changing a single gene or multiple genes in a mouse, scientists can observe how these changes affect the mouse's health and predict how similar changes in human genomes might affect human health.
Scientists at the National Human Genome Research Institute (NHGRI) are doing just this. The Burgess lab, for example, is studying zebrafish genomes. Scientists in this lab delete different genes in zebrafish one at a time using CRISPR to see how the deletion impacts the fish. The Burgess lab focuses on 50 zebrafish genes which are similar to the genes that cause human deafness so that they can better understand the genomic basis of deafness.
Scientists are developing gene therapies - treatments involving genome editing - to prevent and treat diseases in humans. Genome editing tools have the potential to help treat diseases with a genomic basis, like cystic fibrosis and diabetes. There are two different categories of gene therapies: germline therapy and somatic therapy. Germline therapies change DNA in reproductive cells (like sperm and eggs). Changes to the DNA of reproductive cells are passed down from generation to generation. Somatic therapies, on the other hand, target non-reproductive cells, and changes made in these cells affect only the person who receives the gene therapy.
In 2015, scientists successfully used somatic gene therapy when a one-year old in the United Kingdom named Layla received a gene editing treatment to help her fight leukemia, a type of cancer. These scientists did not use CRISPR to treat Layla, and instead used another genome editing technology called TALENs. Doctors tried many treatments before this, but none of them seemed to work, so scientists received special permission to treat Layla using gene therapy. This therapy saved Layla's life. However, treatments like the one that Layla received are still experimental because the scientific community and policymakers still have to address technical barriers and ethical concerns surrounding genome editing.
Even though CRISPR improved upon older genome editing technologies, it is not perfect. For example, sometimes genome editing tools cut in the wrong spot. Scientists are not yet sure how these errors might affect patients. Assessing the safety of gene therapies and improving upon genome editing technologies are critical steps to ensure that this technology is ready for use in patients.
Scientists and all of us should carefully consider the many ethical concerns that can emerge with genome editing, including safety. First and foremost, genome editing must be safe before it is used to treat patients. Some other ethical questions that scientists and society must consider are:
Most people agree that scientists should not edit the genomes of germline cells at this time because the safety and Scientific communities across the world are approaching germline therapy research with caution because edits to a germline cell would be passed down through generations. Many countries and organizations have strict regulations to prevent germline editing for this reason. The NIH, for example, does not fund research to edit human embryos. 152ee80cbc
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