research

We address the challenges of conventional wound care by designing multifunctional bioactive dressings to promote tissue regeneration and accelerate wound healing through improved collagen deposition and enhanced angiogenesis. We also look at delivering inexpensive bioactive molecules to impart antibacterial, anti-inflammatory, and antioxidant properties. Overall, we aim to improve wound healing, reduce complications, and advance the field of biomaterials-based wound management.

Our lab works on developing novel bioactive nanocomposite scaffolds for engineering vascularized bones. We load bioceramics to combinations of natural and synthetic polymers to mimic the natural bone extracellular matrix, thereby promoting osseointegration and bone regeneration. We aim to enhance vascularization by using the right combination of bioactive molecules and natural polymers to design these scaffolds. Through our research efforts, we strive to develop comprehensive solutions for treating bone defects.

Our lab works on developing novel injectable polysaccharide-based hydrogels using hyaluronic acid from recombinant L. lactis for cartilage regeneration. In this project, we focus on enhancing the self-healing efficiency and the lubrication. We are also working on peptide-based drug delivery platforms for the targeted treatment of rheumatoid arthritis. These strategies aim to develop clinically relevant systems to address major challenges in treating cartilage degeneration.

Smart drug delivery systems are engineered for targeted efficacy through site-activated release, enhancing pharmacokinetics and pharmacodynamics while reducing side effects. Our lab develops injectable, minimally invasive systems for various clinical applications. Using pH- and enzyme-responsive mechanisms, we create injectable nanoparticles and hydrogels from natural polymers for sustained, localized drug release. These systems modulate the immune microenvironment and promote site-specific action, addressing conventional therapy limitations. By offering precise and prolonged effects, these injectable systems provide innovative solutions for complex medical challenges with minimal invasiveness.

We focus on engineering surfaces through antifouling coatings that prevent unwanted bioadhesion, reducing bacterial contamination and protein fouling. By incorporating bioinspired and non-toxic surface treatments, we aim to improve biocompatibility, minimize immune responses, and extend the functionality of medical implants and devices. By leveraging these strategies, we strive to develop implants with superior resistance to fouling and enhanced clinical outcomes.