Chemical knowledge, reasoning, and practices are critical for addressing many of the global challenges facing modern societies. To equip students with the knowledge, skills, and dispositions they will need to contribute to these efforts, chemistry educators must take immediate and definitive actions. The systems thinking approach to chemistry education provides a unifying framework for learning and understanding chemistry as more than a static body of knowledge, but rather a dynamic and powerful way of knowing, thinking, and acting to build a safe, healthy, and sustainable world.