Research
Considering that SARS-CoV-2 depends on the host protease TMPRSS2 for entry into lung cells, we are designing, preparing and biologically evaluating new TMPRSS2 inhibitors to block SARS-CoV-2 infection of lung cells. In collaboration with Prof. Stefan Pöhlmann (German Primate Center in Göttingen). Funded by SFI/EI/IDA (Rapid response call) and a SFI-Frontiers of the Future project.
Considering that SARS-CoV-2 depends on the host protease TMPRSS2 for entry into lung cells, we are designing, preparing and biologically evaluating new TMPRSS2 inhibitors to block SARS-CoV-2 infection of lung cells. In collaboration with Prof. Stefan Pöhlmann (German Primate Center in Göttingen). Funded by SFI/EI/IDA (Rapid response call) and a SFI-Frontiers of the Future project.
Preparation and microbiological assessment of piperidine/piperazine guanidinium derivatives as novel anti-mycobacterial agents as inhibitors of InhA. In collaboration with Prof. Stephen Gordon (Conway Institute, UCD, Dublin). Funded by IRC
Preparation and microbiological assessment of piperidine/piperazine guanidinium derivatives as novel anti-mycobacterial agents as inhibitors of InhA. In collaboration with Prof. Stephen Gordon (Conway Institute, UCD, Dublin). Funded by IRC
The design, synthesis and biophysical and biochemical study of new chemical probes targeting Guanine-Quadruplexes. In collaboration with Profs. Mathias Senge (School of Chemistry, TCD) and Jean-Louis Mergny (Institute Curie, France). Funded by IRC.
The design, synthesis and biophysical and biochemical study of new chemical probes targeting Guanine-Quadruplexes. In collaboration with Profs. Mathias Senge (School of Chemistry, TCD) and Jean-Louis Mergny (Institute Curie, France). Funded by IRC.
The design, synthesis and biochemical study of guanidinium derivatives as protein kinase inhibitors. These compounds have shown anticancer activity. In collaboration with Profs. Daniela Zisterer (School of Biochemistry & Immunology, TCD) and Tony McElligott (School of Medicine, TCD). Funded by IRC, the School of Chemistry (TCD) and Ulysses award.
The design, synthesis and biochemical study of guanidinium derivatives as protein kinase inhibitors. These compounds have shown anticancer activity. In collaboration with Profs. Daniela Zisterer (School of Biochemistry & Immunology, TCD) and Tony McElligott (School of Medicine, TCD). Funded by IRC, the School of Chemistry (TCD) and Ulysses award.
The design, synthesis and study of the pharmacological potential of antagonists of alpha2- or alpha2C-adrenoceptors as antidepressants or antipsychotics. These compounds consist in guanidine or 2-aminoimidazoline derivatives connected by a wide range of aromatic or heteroaromatic linkers. In collaboration with Prof. Koldo Callado (School of Medicine, UPV/EHS, Spain). Funded by IRC.
The design, synthesis and study of the pharmacological potential of antagonists of alpha2- or alpha2C-adrenoceptors as antidepressants or antipsychotics. These compounds consist in guanidine or 2-aminoimidazoline derivatives connected by a wide range of aromatic or heteroaromatic linkers. In collaboration with Prof. Koldo Callado (School of Medicine, UPV/EHS, Spain). Funded by IRC.
The design, synthesis and biophysical and biochemical study of new agents targeting DNA as minor-groove binders with potential as more selective anticancer or antiparasitic drugs. Funded by IRC and SFI.
The design, synthesis and biophysical and biochemical study of new agents targeting DNA as minor-groove binders with potential as more selective anticancer or antiparasitic drugs. Funded by IRC and SFI.
The theoretical study of the nature of Hydrogen bonds and other weak interactions and their implications in chemical and biological systems by means of MO calculations and the analysis of the electron density.
The theoretical study of the nature of Hydrogen bonds and other weak interactions and their implications in chemical and biological systems by means of MO calculations and the analysis of the electron density.
Funded by:
Funded by:
