Publications

Ongoing Research Projects

- Inhalable dECM Hydrogel

- Ocular Drug Delivery

- Topical IL HTS for Systemic Macromolecule Delivery

- Photoimmunotherapy using Glycoengineered Cytokine

- Cell membrane NP-assisted Viral Delivery

- Microneedle Platform for Vaccine Delivery

- Vericose Vein Embolic

- AI-based LNP Design for Brain Targeting

- AI-based Novel Peptide Binder Design

- AI-based Dual-target Binding Small Molecule Ligand Generation

- Intranasal Brain Drug Delivery

30. A E. Pazarceviren†, H Keum†, L-P Tricou, M Bastani, D Gaia, B R. Freedman*, D Sheyn*. Tendon-derived injectable bioscaffold augments tenogenicity of iMSCSCX+ and enables tissue engraftment for tendon healing. TBD, Manuscript preparation. [†equally contributed]

29. H Keum†, J Kim†, Z Zhang, H Albadawi, E Cevik, R Oklu*. Thrombolysis, cellular ablation, and drug delivery using an ionic liquid in venous tumor thrombus. TBD, Under review.

28. H Keum†, J Kim†, H Albadawi, E Graf, N Callisen, R Oklu*. Intraosseous delivery of an ionic liquid-based thermoresponsive hydrogel for the treatment of osteomyelitis. Adv. Mater. In revision. [†equally contributed]

27. P Hueso-Jiménez, D Wu, H Keum, B Freedman*. Marine-Derived Medical Devices and Therapeutic Delivery Systems. Adv. Healthcare. Mater. 2026, e05395.

26. J Kim, H Keum, H Albadawi, I Altinbasak, F. Yavuz, E H Graf, N Mishra, R Oklu*. Ionic liquid-reinforced multifunctional hydrogel for the treatment of enterocutaneous fistula. Adv. Mater. 2025, 2503179.

25. J Kim, Z Zhang, H Albadawi, H Keum, J L Mayer, E Graf, R Oklu*. Catheter injectable multifunctional biomaterial for the treatment of infected enterocutaneous fistulas. Adv. Sci. 2025, 2414642.

24. D Kim†, H Keum†, R Kim†, J Choi, M Prayogo, H Kim, D Shin, S MD Abuzar, S Jo, P Kim, C Park*, S Jon*. Synthetic bilirubin-based nanomedicine alleviates atopic dermatitis by reducing oxidative stress and modulating immune responses. Adv. Therap. 2025, 2400403. [†equally contributed]

23. J Kim, H Keum, H Albadawi, E Graf, E Cevik, R Oklu*. Multi-functional biomaterial for the treatment and prevention of central line-associated bloodstream infections. Adv. Mater. 2024, 2405805. [Front cover]

22. H Albadawi†, Z Zhang†, H Keum, E Cevik, B M Nagalo, S Gunduz, H Kita, R Oklu* Percutaneous delivery of oncogel for targeted liver tumor ablation and controlled release of therapeutics. Adv. Mater. 2024, 2406080. [Back cover]

21. H Keum, J Kim, Z Zhang, E Graf, H Albadawi, R Oklu*. Biocompatible liquid embolic for the treatment of microvascular hemorrhage. Adv. Sci. 2024, 2403615. [Front cover]

20. Y Demirlenk, H Albadawi, Z Zhang, D Altar, E Cevik, H Keum, J Kim, P Santos, S Gunduz, E Graf, R Oklu*. Prostate tissue ablation and drug delivery by an image-guided injectable ionic liquid in ex vivo and in vivo models. Sci. Transl. Med. 16, eadn7982 2024.

19. W Jung†, M Asaduddin†, D Yoo, D Lee, Y Son, D Kim, H Keum, J Lee, S Park*, S Jon*. Noninvasive ROS imaging and drug delivery monitoring in the tumor microenvironment. Biomaterials. 310 2024 122633.

18. H Keum, E Cevik, D Altar, J Kim, Y Demirlenk, R Sheth, A Deipolyi, G Saini, R Oklu*. Tissue Ablation: Applications and Perspectives. Adv. Mater. 2024, 2310856. [Back cover].

17. E Cevik, H Albadawi, Z Zhang, Y Demirlenk, D Altar, H Keum, J Kim, E Graf, P Santos, S Gunduz, R Oklu*. Catheter-Directed Ionic Liquid Embolic Agent for Rapid Portal Vein Embolization, Segmentectomy, and Bile Duct Ablation. Adv. Mater. 2024, 2402570.

16. W Jung†, M Asaduddin†, H Keum, D Yoo, D Kim, S Lee, D Lee, J Roh, S Park*, S Jon*. Longitudinal magnetic resonance imaging with ROS-responsive nanoparticles enables monitoring of non-alcoholic steatohepatitis progression to cirrhosis. Adv. Mater. 2024, 2305830.

15. H Keum, H Albadawi, Z Zhang, E Graf, Pedro R D Santos, S Gunduz, R Oklu*. Bioengineered ionic liquid for catheter-directed tissue ablation, drug delivery and embolization. Adv. Mater. 2024, 2309412. [Front cover]

14. C Choi†, H Keum†, S Yang†, B Kang, D Kim, H Piao, J Kim, B Kim, S Yun*, S Jon*. Bilirubin nanomedicine alleviates inflammation and angiogenesis in a rosacea mouse model. Adv. Therap. 2023, 2200223. [†equally contributed]. 

13. T W Kim, Y Kim, H Keum, W Jung, S Jon*. Combination of a STAT3 inhibitor with anti-PD-1 immunotherapy is an effective treatment regimen for a vemurafenib-resistant melanoma. Molecular Therapy- Oncolytics. 26, 1-14, 2022 

12. C Whang†, J Hong†, D Kim, H Ryu, W Jung, Y Son, H Keum, J Kim, H Shin, E Moon, I Noh, H Lee*, S Jon*. Systematic screening and therapeutic evaluation of glyconanoparticles with differential cancer affinities for targeted cancer therapy. Adv. Mater. 2022, 2203993. [Back cover].

11. H Keum†, D Kim†, C Whang, A Kang, S Lee, W Na, S Jon*. Impeding the medical protective clothing contamination by a spray coating of trifunctional polymers. ACS Omega. 2022, 7, 10526-10538. [†equally contributed].

10. H Keum, D Yoo, S Jon*. Photomedicine based on heme-derived compounds. Adv. Drug. Deliv. Rev. 182. 2022. 114134.

9. H Keum, D Kim, J Kim, T W Kim, C Whang, S Jon*. A Bilirubin-derived Nanomedicine Attenuates the Pathological Cascade of Pulmonary Fibrosis. Biomaterials. 275 2021 120986.

8. H Keum, J Kim, T W Kim, D Yoo, C Seo, D Kim, S Jon*. “Biomimetic lipid nanocomplexes incorporating STAT3-inhibiting peptides effectively infiltrate the lung barrier and ameliorate pulmonary fibrosis.” J. Control. Release. 332. 2021. 160-170.

7. T W Kim, Y Kim, W Jung, D E Kim, H Keum, Y Son, S Jon*. Bilirubin nanomedicine ameliorates the progression of experimental autoimmune encephalomyelitis by modulating dendritic cells. J. Control. Release. 331. 2021. 74-84. [Back cover].

6. J Kim, H Keum, H Kim, B Yu, W Jung, C Whang, C Seo, J Park*, S Jon*. “Gold nanorods with an ultrathin anti-biofouling siloxane layer for combinatorial anticancer therapy.” J Drug Target. 2020, 1029-2330.

5. H Keum, T W Kim, Y Kim, C Seo, Y Son, J Kim, D Kim, W Jung, C Whang, S Jon*. “Bilirubin nanomedicine alleviates psoriatic skin inflammation by reducing oxidative stress and suppressing pathogenic signaling.” J. Control. Release. 325. 2020. 359–369360.

4. J Kim, J Lee, Y Kim, H Keum, Y Kim, B Yu, S Y Lee, J Tanaka, S Jon*, M C Choi*. “Tubulin-based nanotubes as a delivery platform for microtubule-targeting agents” Adv. Mater. 2020, 2002902. [Front cover].

3. C Chung, W Jung, H Keum, T W Kim, S Jon*. “Nanoparticles derived from the natural antioxidant, rosmarinic acid, ameliorate acute inflammatory bowel disease.” ACS Nano. 2020, 14, 6887-6896.

2. B Yu, D Hwang, H Jeon, H Kim, Y Lee, H Keum, J Kim, D Y Lee, Y Kim, J Chung*, S Jon*. “A hybrid platform based on a bispecific peptide-antibody complex for targeted cancer therapy.” Angew. Chem. Int. Ed. 2019, 58, 2005–2010.

1. H Keum, J Y Kim, B Yu, S J Yu, J Kim, H Jeon, D Y Lee, S G Im*, S Jon*. “Prevention of bacterial colonization on catheters by a one-step coating process involving an antibiofouling polymer in water.” ACS Appl. Mater. Interfaces. 2017, 9, 23, 19736-19745.