Publications

1. “Antimicrobial Ionic Liquid” TBD.

2. “AI-based Dual-target Binding Ligand Generation” TBD.

3. “Photoimmunotherapy using Glycoengineered Cytokine” TBD.

4. “De novo Albumin Binder” TBD.

5. “Computational Engineering of PSMA Targeting Motif” TBD.

6. “Intranasal Brain Drug Delivery” TBD.

7. A E. Pazarceviren†, H Keum†, D Gaia, M Bastani, L-P Tricou, B R. Freedman*, D Sheyn*. Tendon-derived injectable bioscaffold augments tenogenicity of iMSCSCX+ and enables tissue engraftment for tendon healing. TBD, Manuscript preparation. [†equally contributed]

8. H Keum†, J Kim†, Z Zhang, H Albadawi, E Cevik, R Oklu*. Thrombolysis, cellular ablation, and drug delivery using an ionic liquid in venous tumor thrombus. TBD, Under review.

9. H Keum†, J Kim†, H Albadawi, E Graf, N Callisen, R Oklu*. Intraosseous delivery of an ionic liquid-based thermoresponsive hydrogel for the treatment of osteomyelitis. Adv. Mater. In revision. [†equally contributed]

10. P Hueso-Jiménez, D Wu, H Keum, B Freedman*. Marine-Derived Medical Devices and Therapeutic Delivery Systems. Adv. Healthcare. Mater. 2026, e05395.

11. J Kim, H Keum, H Albadawi, I Altinbasak, F. Yavuz, E H Graf, N Mishra, R Oklu*. Ionic liquid-reinforced multifunctional hydrogel for the treatment of enterocutaneous fistula. Adv. Mater. 2025, 2503179.

12. J Kim, Z Zhang, H Albadawi, H Keum, J L Mayer, E Graf, R Oklu*. Catheter injectable multifunctional biomaterial for the treatment of infected enterocutaneous fistulas. Adv. Sci. 2025, 2414642.

13. D Kim†, H Keum†, R Kim†, J Choi, M Prayogo, H Kim, D Shin, S MD Abuzar, S Jo, P Kim, C Park*, S Jon*. Synthetic bilirubin-based nanomedicine alleviates atopic dermatitis by reducing oxidative stress and modulating immune responses. Adv. Therap. 2025, 2400403. [†equally contributed]

14. J Kim, H Keum, H Albadawi, E Graf, E Cevik, R Oklu*. Multi-functional biomaterial for the treatment and prevention of central line-associated bloodstream infections. Adv. Mater. 2024, 2405805. [Front cover]

15. H Albadawi†, Z Zhang†, H Keum, E Cevik, B M Nagalo, S Gunduz, H Kita, R Oklu* Percutaneous delivery of oncogel for targeted liver tumor ablation and controlled release of therapeutics. Adv. Mater. 2024, 2406080. [Back cover]

16. H Keum, J Kim, Z Zhang, E Graf, H Albadawi, R Oklu*. Biocompatible liquid embolic for the treatment of microvascular hemorrhage. Adv. Sci. 2024, 2403615. [Front cover]

17. Y Demirlenk, H Albadawi, Z Zhang, D Altar, E Cevik, H Keum, J Kim, P Santos, S Gunduz, E Graf, R Oklu*. Prostate tissue ablation and drug delivery by an image-guided injectable ionic liquid in ex vivo and in vivo models. Sci. Transl. Med. 16, eadn7982 2024.

18. W Jung†, M Asaduddin†, D Yoo, D Lee, Y Son, D Kim, H Keum, J Lee, S Park*, S Jon*. Noninvasive ROS imaging and drug delivery monitoring in the tumor microenvironment. Biomaterials. 310 2024 122633.

19. H Keum, E Cevik, D Altar, J Kim, Y Demirlenk, R Sheth, A Deipolyi, G Saini, R Oklu*. Tissue Ablation: Applications and Perspectives. Adv. Mater. 2024, 2310856. [Back cover].

20. E Cevik, H Albadawi, Z Zhang, Y Demirlenk, D Altar, H Keum, J Kim, E Graf, P Santos, S Gunduz, R Oklu*. Catheter-Directed Ionic Liquid Embolic Agent for Rapid Portal Vein Embolization, Segmentectomy, and Bile Duct Ablation. Adv. Mater. 2024, 2402570.

21. W Jung†, M Asaduddin†, H Keum, D Yoo, D Kim, S Lee, D Lee, J Roh, S Park*, S Jon*. Longitudinal magnetic resonance imaging with ROS-responsive nanoparticles enables monitoring of non-alcoholic steatohepatitis progression to cirrhosis. Adv. Mater. 2024, 2305830.

22. H Keum, H Albadawi, Z Zhang, E Graf, Pedro R D Santos, S Gunduz, R Oklu*. Bioengineered ionic liquid for catheter-directed tissue ablation, drug delivery and embolization. Adv. Mater. 2024, 2309412. [Front cover]

23. C Choi†, H Keum†, S Yang†, B Kang, D Kim, H Piao, J Kim, B Kim, S Yun*, S Jon*. Bilirubin nanomedicine alleviates inflammation and angiogenesis in a rosacea mouse model. Adv. Therap. 2023, 2200223. [†equally contributed]. 

24. T W Kim, Y Kim, H Keum, W Jung, S Jon*. Combination of a STAT3 inhibitor with anti-PD-1 immunotherapy is an effective treatment regimen for a vemurafenib-resistant melanoma. Molecular Therapy- Oncolytics. 26, 1-14, 2022 

25. C Whang†, J Hong†, D Kim, H Ryu, W Jung, Y Son, H Keum, J Kim, H Shin, E Moon, I Noh, H Lee*, S Jon*. Systematic screening and therapeutic evaluation of glyconanoparticles with differential cancer affinities for targeted cancer therapy. Adv. Mater. 2022, 2203993. [Back cover].

26. H Keum†, D Kim†, C Whang, A Kang, S Lee, W Na, S Jon*. Impeding the medical protective clothing contamination by a spray coating of trifunctional polymers. ACS Omega. 2022, 7, 10526-10538. [†equally contributed].

27. H Keum, D Yoo, S Jon*. Photomedicine based on heme-derived compounds. Adv. Drug. Deliv. Rev. 182. 2022. 114134.

28. H Keum, D Kim, J Kim, T W Kim, C Whang, S Jon*. A Bilirubin-derived Nanomedicine Attenuates the Pathological Cascade of Pulmonary Fibrosis. Biomaterials. 275 2021 120986.

29. H Keum, J Kim, T W Kim, D Yoo, C Seo, D Kim, S Jon*. “Biomimetic lipid nanocomplexes incorporating STAT3-inhibiting peptides effectively infiltrate the lung barrier and ameliorate pulmonary fibrosis.” J. Control. Release. 332. 2021. 160-170.

30. T W Kim, Y Kim, W Jung, D E Kim, H Keum, Y Son, S Jon*. Bilirubin nanomedicine ameliorates the progression of experimental autoimmune encephalomyelitis by modulating dendritic cells. J. Control. Release. 331. 2021. 74-84. [Back cover].

31. J Kim, H Keum, H Kim, B Yu, W Jung, C Whang, C Seo, J Park*, S Jon*. “Gold nanorods with an ultrathin anti-biofouling siloxane layer for combinatorial anticancer therapy.” J Drug Target. 2020, 1029-2330.

32. H Keum, T W Kim, Y Kim, C Seo, Y Son, J Kim, D Kim, W Jung, C Whang, S Jon*. “Bilirubin nanomedicine alleviates psoriatic skin inflammation by reducing oxidative stress and suppressing pathogenic signaling.” J. Control. Release. 325. 2020. 359–369360.

33. J Kim, J Lee, Y Kim, H Keum, Y Kim, B Yu, S Y Lee, J Tanaka, S Jon*, M C Choi*. “Tubulin-based nanotubes as a delivery platform for microtubule-targeting agents” Adv. Mater. 2020, 2002902. [Front cover].

34. C Chung, W Jung, H Keum, T W Kim, S Jon*. “Nanoparticles derived from the natural antioxidant, rosmarinic acid, ameliorate acute inflammatory bowel disease.” ACS Nano. 2020, 14, 6887-6896.

35. B Yu, D Hwang, H Jeon, H Kim, Y Lee, H Keum, J Kim, D Y Lee, Y Kim, J Chung*, S Jon*. “A hybrid platform based on a bispecific peptide-antibody complex for targeted cancer therapy.” Angew. Chem. Int. Ed. 2019, 58, 2005–2010.

36. H Keum, J Y Kim, B Yu, S J Yu, J Kim, H Jeon, D Y Lee, S G Im*, S Jon*. “Prevention of bacterial colonization on catheters by a one-step coating process involving an antibiofouling polymer in water.” ACS Appl. Mater. Interfaces. 2017, 9, 23, 19736-19745.