Publications

2022

IR Taylor, LA Murray-Nerger, TM Greco, D Liu, IM Cristea, BL Bassler, mBio 2022 "Protein interaction networks of catalytically active and catalytically inactive PqsE in Pseudomonas aeruginosa" DOI: 10.1128/mbio.01559-22

IR Taylor, PD Jeffrey, DA Moustafa, JB Goldberg, BL Bassler, Biochemistry 2022 "The PqsE active site as a target for small molecule antimicrobial agents against Pseudomonas aeruginosa" DOI: 10.1021/acs.biochem.2c00334 *Featured on cover: https://pubs.acs.org/toc/bichaw/61/17

A Shkedi, IR Taylor, F Echtenkamp, P Ramkumar, M Alshalalfa, GM Rivera-Márquez, MA Moses, H Shao, RJ Karnes, L Neckers, F Fang, M Kampmann, JE Gestwicki, Cell Chem Biol. 2022 "Selective vulnerabilities in the proteostasis network of castration resistant prostate cancer" DOI: 10.1016/j.chembiol.2022.01.008

KA Simanek, IR Taylor, EK Richael, E Lasek-Nesselquist, BL Bassler, JE Paczkowski, Microbiol Spectr. 2022 "The PqsE-RhlR interaction regulates RhlR DNA binding to control virulence factor production in Pseudomonas aeruginosa" DOI: 10.1128/spectrum.02108-21

2021

IR Taylor, JE Paczkowski, PD Jeffrey, BR Henke, CD Smith, BL Bassler, ACS Chem Biol. 2021 "Inhibitor mimetic mutations in the Pseudomonas aeruginosa PqsE enzyme reveal a protein-protein interaction with the quorum-sensing receptor RhlR that is vital for virulence factor production" DOI: 10.1021/acschembio.1c00049

J Abrams, T Arhar, SA Mok, IR Taylor, M Kampmann, JE Gestwicki, Cell Stress Chaperones 2021 "Functional genomics screen identifies proteostasis targets that modulate prion protein (PrP) stability" DOI: 10.1007/s12192-021-01191-8

2020

IR Taylor, VA Assimon, SY Kuo, S Rinaldi, X Li, ZT Young, G Morra, K Green, D Nguyen, H Shao, S Garneau-Tsodikova, G Colombo, JE Gestwicki, Chem Sci. 2020 "Tryptophan scanning mutagenesis as a way to mimic the compound-bound state and probe the selectivity of allosteric inhibitors in cells" DOI: 10.1039/c9sc04284a

JS Valastyan, MR Tota, IR Taylor, V Stergioula, GAB Hone, CD Smith, BR Henke, KG Carson, BL Bassler, ACS Chem Biol. 2020 "Discovery of PqsE thioesterase inhibitors for Pseudomonas aeruginosa using DNA-encoded small molecule library screening" DOI: 10.1021/acschembio.9b00905

2019

SM Moss, IR Taylor, D Ruggero, JE Gestwicki, KM Shokat, S Mukherjee, Cell Host Microbe. 2019 "A Legionella pneumophila kinase phosphorylates the Hsp70 chaperone family to inhibit eukaryotic protein synthesis" DOI: 10.1016/j.chom.2019.01.006

2018

S Rinaldi, VA Assimon, ZT Young, G Morra, H Shao, IR Taylor, JE Gestwicki, G Colombo, ACS Chem Biol. 2018 "A local allosteric network in heat shock protein 70 (Hsp70) links inhibitor binding to enzyme activity and distal protein-protein interactions" DOI: 10.1021/acschembio.8b00712

IR Taylor, A Ahmad, T Wu, BA Nordhues, A Bhullar, JE Gestwicki, ERP Zuiderweg, J Biol Chem. 2018 "The disorderly conduct of Hsc70 and its interaction with the Alzheimer's-related Tau protein" DOI: 10.1074/jbc.RA118.002234

IR Taylor, BM Dunyak, T Komiyama, H Shao, X Ran, VA Assimon, C Kalyanaraman, JN Rauch, MP Jacobson, ERP Zuiderweg, JE Gestwicki, J Biol Chem. 2018 "High-throughput screen for inhibitors of protein-protein interactions in a reconstituted heat shock protein 70 (Hsp70) complex" DOI: 10.1074/jbc.RA117.001575

2016

X Li, H Shao, IR Taylor, JE Gestwicki, Curr Top Med Chem. 2016 "Targeting allosteric control mechanisms in heat shock protein 70 (Hsp70)" DOI: 10.2174/1568026616666160413140911

2013

SS Jain, CM Anderson, F DiRienzo, IR Taylor, K Jain, S Guha, N Hoque, Chem Commun (Camb). 2013 "RNA binding and inhibition of primer extension by a Ru(III)/Pt(II) metal complex" DOI: 10.1039/c3cc40699g

2012

CM Anderson, IR Taylor, MF Tibbetts, J Philpott, Y Hu, JM Tanski, Inorg Chem. 2012 "Hetero-multinuclear ruthenium(III)/platinum(II) complexes that potentially exhibit both antimetastatic and antineoplastic properties" DOI: 10.1021/ic301981s