Name: Tatsuya Sakaguchi
Affiliation: Chemistry of Functional Molecules, Graduate School of Biomedical Sciences, Nagasaki University
Address: Nagasaki 852-8521 Japan
Tel: +81 95-819-2439
Links: ORCID, LinkedIn, GitHub, GoogleScholar
April 2006 - March 2010. Bachelor of Science in Chemistry, Hokkaido University, Sapporo, Japan.
April 2010 - March 2012. Master of Science in Chemistry, Hokkaido University, Sapporo, Japan.
April 2012 - March 2015. Ph.D. in Chemistry, Hokkaido University, Sapporo, Japan. Thesis Title: Study on Silver Nanostructures Formed through Oligomerization and Orientation of Biomineralization Peptides
April 2015 - March 2020. Assistant professor, Department of Chemistry, Kurume University School of Medicine, Kurume, Japan.
August 2019 - March 2023. Visiting Scholar, Department of Biochemistry, University of Montreal, Montreal, Canada.
April 2023 - September 2025. Assistant professor, Department of Chemistry, Kurume University School of Medicine, Kurume, Japan.
October 2025 - present. Assistant professor, Chemistry of Functional Molecules, Graduate School of Biomedical Sciences, Nagasaki University.
Bio-Algorithms and Med-Systems
BioNanoScience
Ecological Chemistry and Engineering S
2010 - present. The Chemical Society of Japan.
2010 - present. The Japanese Peptide Society.
2015 - present. The Japanese Biochemical Society.
2017 - present. Japanese Society for Bioinformatics.
2018 - present. The Molecular Biology Society of Japan.
2025 - present. The Pharmaceutical Society of Japan.
2010, Excellent presentation award, The Chemical Society of Japan Hokkaido branch.
2012, Repayment Exemption for Students with Excellent Grades, Japan Student Services Organization (JASSO) Type I (interest-free) scholarship (Exemption of all of the loan)
2012, Excellent Young Scientist Presentation Award, The Japanese Peptide Society.
2013, Excellent presentation award, The Chemical Society of Japan Hokkaido branch.
2014, The Japanese Biochemical Society (JSBi) Certified Bioinformatics Engineer.
2019, The Uehara Memorial Foundation Post-doctoral Fellowship (Budget ¥3,900,000)
JSPS KAKEN Grant (12J02657), "Structural control of inorganic nanomaterials by biomineralization based on multimerization and orientation." Role: Research Fellow, 2012 - 2015. (Budget ¥2,700,000).
JSPS KAKEN Grant (16K07307), "Relationship between regulation of heme oxygenase function by posttranslational modification and disease onset due to its breakdown." Role: Co-Investigator, 2016 - 2018.
JSPS KAKEN Grant (19K06574), "Mechanism of activity regulation by posttranslational modification of novel medical gas carbon monoxide (CO) producing enzyme." Role: Co-Investigator, 2019 - 2022.
JSPS KAKEN Grant (24K10046), "Development of aptamers targeting cell adhesion factors characteristically highly expressed in combined hepatocellular-cholangiocarcinoma and evaluation of their anti-tumor effects." Role: Co-Investigator, 2024-2027.
Ishibashi Foundation for the Promotion of Science Grant, "Exploration of new drug targets for bacterial efflux systems through a comprehensive analysis of dynamic protein-protein interaction networks." Role: Research Fellow, 2024-2025. (Budget ¥2,000,000)
JSPS KAKEN Grant (25K00273), "Elucidation of Drug Response Mechanisms in Bacteria Based on Endogenous Protein-Protein Interaction Network Analysis." Role: Research Fellow, 2025-2028. (Budget ¥4,680,000 (Direct Cost ¥3,600,000, Indirect Cost ¥1,080,000)
General biochemical experiments
Genome editing (CRISPR/Cas9)
Peptide synthesis
Electron microscopic observation (STEM, TEM, SEM)
programming (Python, R, MATLAB/Octave, Perl)
Bioinformatics
Basic machine learning
Genomic Data Science (Specialization consisting of 8 courses) | Johns Hopkins University (Coursera)
Finding Hidden Messages in DNA (Bioinformatics I) | UC San Diego (Coursera)
Genome Sequencing (Bioinformatics II) | UC San Diego (Coursera)
Comparing Genes, Proteins, and Genomes (Bioinformatics III) | UC San Diego (Coursera)
2012 - 2015. Teaching assistant of experimental biochemical practice for third-year university students.
2015 - 2019. The Basic chemistry of life for first-year university students in the Department of Medicine, Kurume University School of Medicine.
2015 - 2019. Chemistry experimental practice for first-year university students in the Department of Medicine, Kurume University School of Medicine.
2015 - 2019. Basic chemistry for first-year university students in the Department of Nursing, Kurume University School of Medicine.
2015 - 2019. Basic chemistry for students in literature, Kurume University.
2017 - 2019. Basic chemistry for first-year students in Kurume University School for Medical Technology.
T. Sakaguchi, R. Kamada, T. Nomura, Y. Chuman, T. Imagawa, K. Sakaguchi, "Activation enhancement and structural control of biomineralization by spatial orientation control via p53 tetramer formation domain," The 90th CSJ Annual Meeting, 2010, Osaka, Japan.
T. Sakaguchi, R. Kamada, T. Nomura, Y. Chuman, T. Imagawa, K. Sakaguchi, "Structural control of silver particles by fusion of p53 tetramer-forming domain and biomineralization peptide," Summer research meeting of CSJ Hokkaido branch 2010, 2010, Hokkaido, Japan.
T. Sakaguchi, R. Kamada, T. Nomura, Y. Chuman, T. Imagawa, K. Sakaguchi, "Improvement of activity by multimerization of biomineralization peptides and structural control of silver particles," The 43rd Japanese Peptide Society Young Scientists meeting, 2010, Hyogo, Japan.
T. Sakaguchi, R. Kamada, Y. Chuman, K. Sakaguchi, "Silver particle formation by multimerization biomineralization peptide via p53 tetramer formation domain," The 92nd CSJ Annual Meeting, 2012, Kanagawa, Japan.
T. Sakaguchi, J.I.B. Janairo, Y. Chuman, K. Sakaguchi, "Control of silver particle structure by oriented biomineralization peptide using p53 tetramer formation domain," Summer research meeting of CSJ Hokkaido branch 2012, 2012, Hokkaido, Japan.
T. Sakaguchi, R. Kamada, Y. Chuman, K. Sakaguchi, "Silver crystal formation by biomineralization peptide oligomerized through p53 tetramerization domain," HU-AGH-Joint Symposium, 2012, Kraków, Poland.
T. Sakaguchi, J.I.B. Janairo, Y. Chuman, K. Hara, A. Fukuoka, K. Sakaguchi, "Silver Nanocrystals Formed by Oligomeric Biomineralization Peptide via p53 Tetramerization Domain," The 49th Japanese Peptide Symposium, 2012, Kagoshima, Japan.
T. Sakaguchi, J.I.B. Janairo, Y. Chuman, K. Hara, A. Fukuoka, K. Sakaguchi, "Silver nanocrystal formation by biomineralization peptide bound to p53 tetramer formation domain," The 93rd CSJ Annual Meeting, 2013, Shiga, Japan.
T. Sakaguchi, J.I.B. Janairo, Y. Chuman, K. Hara, A. Fukuoka, K. Sakaguchi, "Silver particle formation of biomineralization peptide fused to the multimeric scaffold," Summer research meeting of CSJ Hokkaido branch 2013, 2013, Hokkaido, Japan.
T. Sakaguchi, J.I.B. Janairo, J. Wada, K. Sakaguchi, "Control of Silver Nanoparticle Formation by Oligomerization and Orientation of Biomineralization Peptide," The 94th CSJ Annual Meeting, 2014, Aichi, Japan.
T. Sakaguchi, K. Mine, F. Kudoh, R. Kamada, K. Sakaguchi, "Silver nanostructure control by multimerization/orientation of biomineralization peptides based on multimerized peptides," Research meeting of Japanese Biochemical Society Kyushu branch 2015, 2015, Fukuoka, Japan.
T. Sakaguchi, Y. Higashimoto, "Estimation of function range of gene by meta-analysis of microarray," Research meeting of Japanese Biochemical Society Kyushu branch 2018, 2018, Fukuoka, Japan.
T. Sakaguchi, T.K.C. Bahadur, A. Serohijos, "Development of a multi-site bacterial genome editing method for targeting the entire genome", Rencontre Louis-Philippe Bouthillier, 2022, Orford, Canada.
T. Sakaguchi, S. Besse, L. Gauthier, Z. Sahaf, O. Peloquin, L. Gonzalez, X. Castellanos-Girouard, N. Koxatug, C. Matta, J.G. Hussin, S.W. Michnick, A.W.R. Serohijos, "Mapping Protein-interaction Quantitative Trait Loci (piQTL) Unveils a Novel Aspect of Gene-Environment Interactions", MonBUG, 2024, Montreal, Canada.
T. Sakaguchi, R. Kamada, T. Nomura, Y. Chuman, T. Imagawa, K. Sakaguchi, "Biomineralization Activity of Multivalent minTBP-1 Peptide Mediated by p53 Tetramerization Domain," The 46th Japanese Peptide Symposium, 2009, Fukuoka, Japan.
T. Sakaguchi, R. Kamada, K. Sakaguchi, "Effect of Peptide Oligomerization Mediated by p53 Tetramerization Domain on Biomineralization Activity," The 5th International Peptide Symposium, 2010, Kyoto, Japan.
T. Sakaguchi, R. Kamada, Y. Chuman, K. Sakaguchi, "Nanostructure Formed by Biomineralization Peptide Oligomerized via p53 Tetramerization," The 48th Japanese Peptide Symposium, 2011, Hokkaido, Japan.
T. Sakaguchi, R. Kamada, Y. Chuman, K. Sakaguchi, "Silver nanoparticle formation by using oligomerized biomineralization peptide via p53 tetramerization domain," The 1st Frontier Chemistry Center International Symposium, 2012, Hokkaido, Japan.
T. Sakaguchi, J.I.B. Janairo, Y. Chuman, K. Hara, A.Fukuoka, K. Sakaguchi, "Silver Nanoparticle Formation by Oligomeric Biomineralization Peptide via p53 Tetramerization Domain," 2012 HU-NU-SNU-NIMS/MANA Joint Symposium, 2012, Hokkaido, Japan.
T. Sakaguchi, J.I.B. Janairo, Y Chuman, K. Sakaguchi, "Structure control of silver nanoparticles by orientation control of biomineralization peptides using oligomerization peptides," The 9th Nanjing-Hokkaido-NIMS/MANA Joint Symposium on the Cutting Edge Chemistry, 2013, Nanjing, China.
T. Sakaguchi, J.I.B. Janairo, Y Chuman, K. Sakaguchi, "Effect of Oligomerization of Biomineralization Peptides on Formation and Structure of Silver Nanoparticles," The 4th Asia-Pacific International Peptide Symposium, 2013, Osaka, Japan.
T. Sakaguchi, J.I.B. Janairo, Y Chuman, K. Sakaguchi, "Development of Nanostructure Control Method via Oligomerization of Biomineralization Peptide," The 2nd Frontier Chemistry Center International Symposium, 2013, Hokkaido, Japan.
T. Sakaguchi, J.I.B. Janairo, Y Chuman, K. Sakaguchi, "Effect of Oligomerization and Orientation of Biomineralization Peptides on Formation and Structure of Silver Nanoparticles," The 3rd Frontier Chemistry Center International Symposium, 2014, Hokkaido, Japan.
T. Sakaguchi, S. Sasaki, K. Mine, K. Sakaguchi, "Silver Nanoparticles Formed by Oligomeric Biomineralization Peptide Conjugated with DNA," The 51st Japanese Peptide Symposium, 2014, Tokushima, Japan.
T. Sakaguchi, K. Mine, F. Kudoh, R. Kamada, K. Sakaguchi, "Silver Nano-structure Control by Oligomerization and Orientation Control of Biomineralization Peptide using Oligomeric Peptides," BMB2015, 2015, Hyogo, Japan.
T. Sakaguchi, Y. Higashimoto, "Meta-Analysis of Microarrays to Search PEDF-Related Genes," The 6th Informatics in Biology Medicine and Pharmacology (IIBMP2017), 2017, Hokkaido, Japan.
T. Sakaguchi, Y. Higashimoto, "Search for related genes of pigment epithelium-derived factor PEDF by meta-analysis of microarray," BMB2017, 2017, Hyogo, Japan.
T. Sakaguchi, Y. Higashimoto, "Estimation of the influence range of genes based on the expression correlation genes," The 7th Informatics in Biology Medicine and Pharmacology (IIBMP2018), 2018, Yamagata, Japan.
T. Sakaguchi, Y. Higashimoto, "Development of comprehensive gene function estimation method based on the expression-correlated genes," The 41st Annual Meeting of the Molecular Biology Society of Japan, 2018, Kanagawa, Japan.
T. Sakaguchi, T.K.C. Bahadur, A. Serohijos, "Development of a multi-site bacterial genome editing method for targeting the entire genome", Rencontre Louis-Philippe Bouthillier, 2022, Orford, Canada.
( * : contributed equally)
J.I.B. Janairo*, T. Sakaguchi* , K. Mine, R. Kamada, K. Sakaguchi, Synergic Strategies for the Enhanced Self-Assembly of Biomineralization Peptides for the Synthesis of Functional Nanomaterials, Protein Peptide Lett., 25 (1), 4-14 (2018).
T. Sakaguchi, Y. Irifune, R. Kamada, K. Sakaguchi, Bacterial Systematic Genetics and Integrated Multi-Omics: Beyond Static Genomics Toward Predictive Models, Int. J. Mol. Sci., 26(19), 9326 (2025)
T. Sakaguchi, R. Kamada, T. Nomura, Y Chuman, T. Imagawa, K. Sakaguchi, Biomineralization Activity of Multivalent minTBP-1 Peptide Mediated by p53 Tetramerization Domain, Peptide Science, 2009, 441 (2010).
T. Sakaguchi, R. Kamada, K. Sakaguchi, Effect of Peptide Oligomerization Mediated by p53 Tetramerization Domain on Biomineralization Activity, Peptide Science, 2010, 269 (2011).
T. Sakaguchi, R. Kamada, Y. Chuman, K. Sakaguchi, Nanostructure Formed by Biomineralization Peptide Oligomerized via p53 Tetramerization, Peptide Science, 2011, 345 (2012).
T. Sakaguchi, J.I.B. Janairo, Y. Chuman, K. Hara, A. Fukuoka, K. Sakaguchi, Silver Nanocrystals Formed by Oligomeric Biomineralization Peptide via p53 Tetramerization Domain, Peptide Science, 2012, 57 (2013).
J.I.B. Janairo, T. Sakaguchi, K. Hara, A. Fukuoka, K. Sakaguchi, Effects of biomineralization peptide topology on the structure and catalytic activity of Pd nanomaterials, Chem. Commun., 50 (66), 9259-9262 (2014).
T. Sakaguchi, K. Mine, F. Kudoh, R. Kamada, K. Sakaguchi, Antiproliferative Activity of Silver Nanoplates on Human Promyelocytic Leukemia Cell Lines, Chem. Lett., 44 (3), 327-329 (2015).
Y. Ishibashi, T. Matsui, F. Isami, Y. Abe, T. Sakaguchi, Y. Higashimoto, S.I. Yamagishi, N-butanol extracts of Morinda citrifolia suppress advanced glycation end products (AGEs)-induced inflammatory reactions in endothelial cells through its anti-oxidative properties, BMC Complement Altern. Med., 17 (1), 137 (2017).
S.I. Yamagishi, T. Matsui, Y. Ishibashi, F. Isami, Y. Abe, T. Sakaguchi, Y. Higashimoto, Phytochemicals against advanced glycation end products (AGEs) and the receptor system, Curr. Pharm. Des., 23 (8), 1135-1141 (2017).
T. Sakaguchi, J.I.B. Janairo, M. Lussier-Price, J. Wada, J.G. Omichinski, K. Sakaguchi, Oligomerization enhances the binding affinity of a silver biomineralization peptide and catalyzes nanostructure formation, Sci. Rep., 7 (1), 1400 (2017).
Y. Nishino, T. Sakaguchi, Y. Higashimoto, T. Matsui, S.I. Yamagishi, Cellulose-derived charcoal binds to glyceraldehyde-driven advanced glycation end products in vitro, Diabetes Frontier Online, 5, e1-008 (2018).
Y. Higashimoto, K. Tanaka, T. Matsui, T. Sakaguchi, S.I. Yamagishi, Y. Motomiya, Fibroblast Growth Factor 23 Contributes to Regulation of Hepcidin/Ferroportin Axis, Austin. J. Pharmacol. Ther., 8(1), 1118 (2020)
T. Sakaguchi, N. Nakagawa, K. Mine, J.I.B. Janairo, R. Kamada, J.G. Omichinski, K. Sakaguchi, Biomineralization through a Symmetry-Controlled Oligomeric Peptide, Biomimetics, 8, 606 (2023).
S Besse, T. Sakaguchi, L. Gauthier, Z. Sahaf, O. Péloquin, L. Gonzalez, X. Castellanos-Girouard, N. Koçatug, C. Matta, J.G. Hussin, S.W. Michnick, A.W.R. Serohijos, Genetic landscape of an in vivo protein interactom, bioRxiv, https://doi.org/10.1101/2023.12.14.571726 (2023).
T. Matsui, T. Sakaguchi, Y. Higashimoto, Y. Nishino, A. Sotokawauchi, Y. Koga, S.I. Yamagishi, Sulforaphane inhibits cardiac fibrosis induced by advanced glycation end product-receptor axis through its anti-oxidative property, Acta Diabetol., 62(9), 1569-1572 (2025).
Last Update: 2025/10/1