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Development of Organ-on-chip model for evaluation of Rheumatoid Arthritis

Publications

Formulation and Evaluation of an Anti-inflammatory Topical Polyherbal Gel

Jaya Patel, Nikunjana A. Patel, Tarun Lal

Article Published in Journal of Natural Remedies

Abstract:

Inflammation is currently treated with NSAIDs. Unfortunately, these drugs increase the risk of blood clots, heart attacks, and strokes. Therefore, the development of potent anti-inflammatory drugs from natural products is currently being investigated. Natural products made from medicinal plants play an important role in curing many diseases associated with inflammation. Conventional anti-inflammatory drug available in the market has various side effects. Because of these side effects, there is a need to look for newer drugs with fewer or no side effects. The objective of the present study was to develop polyherbal gel containing hydroalcoholic extract of Berberis  aristata root, Rubia  cordifolia root and Boswellia serrata gum by using Carbopol 934 and Propylene glycol. The 32 factorial design was constructed using concentration of polymer (carbopol 934) and penetration enhancer (Propylene glycol) as independent variables while Viscosity (m.Pas), % in vitro release of Berberine, Rubiadin and AKBA as dependent variables, total 9 possible experimental runs formulate and evaluate. The optimized gel was selected by design of expert employing the overlay plot with desirability approach. Optimized gel showed 39568 m.Pas viscosity, drug content of Berberine 0.48 mg, Rubiadin 0.42 mg and AKBA 0.51 mg. In vivo and histopathology study revealed that prepared gel showed good anti-inflammatory activity.

Rheumatoid arthritis: an overview 

Article Published in International Journal of Research and Analytical Reviews.

Abstract:

Rheumatoid Arthritis is a chronic autoimmune inflammatory disease that affects joints, connective tissues, muscle, tendons and fibrous tissues. The origin of RA varies patient to patient therefore it is difficult to track its origin. In world population mainly 0.5-1% are affected out of which women are more prone to develop RA. There are many co-related factors which leads to development and progression of RA. depending upon causes RA can be classified into many categories. The current medication of RA will provide symptomatic relief as well as it will control the progression of RA but are unable to cure RA as RA is an autoimmune disorder.

Development and evaluation of poly-herbal Formulation for treatment of rheumatoid arthritis 

Thesis submitted to Parul University.