Research achievements 

updated Apr. 27, 2023

Research filed

Bioengineering，Mechanobiology，Instrumentation engineering，Machine learning

I'm interested in ''multicellular dynamics in a mechanical fluctuated environment"

How does the mechanical environment affect multicellular dynamics, one of the key factors in the organization of biological tissue?

Is it possible to freely control tissue formation by mechanical stimulation?

Institution (2023.4.1～)

• Project Assistant Professor, Graduate School of Science and Technology, Keio University, Kanagawa, Japan

• Adjunct Lecturer, Department of Mechanical Engineering, School of Science and Technology, Meiji University, Kanagawa, Japan

• Visiting Researcher, Faculty of Science and Technology, Keio University, Kanagawa, Japan.

Academic background

Mar. 2017: Bachelor of Engineering, Keio University, Kanagawa, Japan 

Mar. 2019: Master of Engineering, Keio University, Kanagawa, Japan 

Mar. 2022: Ph.D. of Engineering, Keio University, Kanagawa, Japan

Academic society

• The Japan Society of Mechanical Engineers

• Japanese Society for Medical and Biological Engineering

Representative research achievements

Original paper (7)

• Imashiro C, Morikura T, Hayama M, Ezura A, Komotori J, Miyata S, Sakaguchi K, Shimizu T. Metallic vessel with mesh culture surface fabricated using three-dimensional printing engineers tissue culture environment, Biotechnol. Bioproc. E., 2023, 23, 181-191. (IF:3.386, 2021)

• Nishi R, Oda Y, Morikura T, Miyata S. Effect of compressive stress in tumor microenvironment on malignant tumor spheroid invasion process., Int. J. Mol. Sci., 2022, 23(13), 7091. (IF: 6.208, 2021)

• Imashiro C, Takeshita H, Morikura T, Miyata S, Takemura K, Komotori J. Development of accurate temperature regulation culture system with metallic culture vessel demonstrates different thermal cytotoxicity in cancer and normal cells., Sci. Rep., 2021, 11(1), 21466. (IF: 4.996, 2021)

• Morikura T, Miyata S. Mechanical Intermittent Compression Affects the Progression Rate of Malignant Melanoma Cells in a Cycle Period-Dependent Manner. Diagnostics, 2021, 11(6), 1112. (IF: 3.992, 2021) 

• Imashiro C, Hirano M, Morikura T, Fukuma Y, Ohnuma K, Kurashina Y, Miyata S, Takemura K. Detachment of cell sheets from clinically ubiquitous cell culture vessels by ultrasonic vibration. Sci. Rep., 2020, 10(1), 9468. (IF: 4.996, 2021)

• Morikura T, Miyata S. Effect of Mechanical Compression on Invasion Process of Malignant Melanoma Using In Vitro Three-Dimensional Cell Culture Device. Micromachines, 2019, 10(10), 666. (IF: 3.523, 2021)

• Bansai S, Morikura T, Onoe H, Miyata S. Effect of Cyclic Stretch on Tissue Maturation in Myoblast-Laden Hydrogel Fibers. Micromachines, 2019, 10(6), 399. (IF: 3.523, 2021)

Awards (5)

• Morikura T, Young Researcher Award (Best Oral Presentation Award), The Society of Materials Science, Japan (JSMS), Dynamic Electronic Speckle Interference Microscopy Using Dielectrophoretic-induced Stress Wave for Observing Cells Located Deep Within In vitro Three-dimensional Hydrogel Culture (6th International Conference on Materials and Reliability), 2022 Dec 8.

• Morikura T，Oustanding Student Presentation賞，日本機械学会，高速ラベルフリー三次元細胞形状計測に向けた深層学習に基づくシングルショット計算顕微鏡法（第32回 バイオフロンティア講演会），2022 Jan 13.

• Nagatomo T，Morikura T，優秀賞，Keio Leading-edge Laboratory of Science and Technology. （KLL），技術特化型ICOプラットフォームの構築とLABLICの事業化（第20回 慶應科学技術展 KEIO TECHNO-MALLアイデアコンテスト），2019 Dec 13.

• Morikura T，Young Investigator’s Award 優秀賞，Japanese Society for Medical and Biological Engineering，間欠的圧縮変形刺激がin vitro三次元悪性黒色腫モデルの細胞増殖を伴う浸潤プロセスに与える影響（第58回 日本生体医工学会大会），2019 June 7.

• Morikura T，BEST POSTER AWARD，CELLAB-SOCU SUMMER SYMPOSIUM，機械的圧縮刺激が悪性黒色腫の進展プロセスに与える影響，2018 Sep 6.

For detailed research achievements, please refer to the following files

(in Japanese)