GlycoForum Retrat 2019 Highlights
April 24 - 25, at the Pacific Hot Spring Hotel Green Bay (愛琴海太平洋溫泉會館).
Invited Foreign Scientists: Stephen Withers (University of British Columbia), Todd Lowary (University of Alberta)
95 participants, 30 short talks by Glycoscientists.
Scientific Sessions Coordinators : Shang-Cheng Hung & Kay-Hooi Khoo & Takashi Angata
Retreat Coordinators : Grace Chen , Pei-Ru Liao
Stephen Withers (University of British Columbia) : Discovery of CAZYmes for cell surface glycan removal through metagenomics: Towards universal blood
Hsiu-Chung Tu (杜秀中, 林伯樵實驗室, 中山大學化學系) : Direct screening of glycan patterns from human sera: A selective glycoprotein microarray strategy
Cheng-Chung Wang (王正中, 中研院化學所) : Indicator-assisted control and guidelines for glycosylation reactions via reactivity and intermediate
I -Ming Lee (李益銘, 吳世雄實驗室, 中研院生化所) : Pseudaminic acid on the exopolysaccharide of Acinetobacter baumannii plays a critical role in phage tail-spike protein-assisted preparation of glycoconjugate with high antigenicity
Huang-Yi Li (李皇毅, 鄭偉杰實驗室, 中研院基因體中心) : Polyhydroxylated pyrrolidine-based iminosugars stabilize Rh--glucosidase and their therapeutic potential toward Pompe Disease
Jiun-Jie Shie (謝俊結, 中研院化學所) : New chemical strategies for glycan synthesis and imaging
Mohammad Tarique Anwar (林俊成實驗室, 清華大學化學系) : Chemoenzymatic Synthesis of Bi-antennary N-Glycans and Their Mimic as Potential Ligand for Siglec-7
Li-Ting Chiu (邱莉婷, 洪上程實驗室, 中研院基因體中心) : Substrates and inhibitors for human endo-sulfatase I
Chien-Fu Liang (梁健夫, 中興大學化學系) : Two new orthogonal protecting groups: Design and application in carbohydrate synthesis
Ching-Ching Yu (游景晴, 中正大學化生系) : Enzymatic synthesis of fucosylated glycans
Chi-Kung Ni (倪其焜, 中研院原分所) : New mass spectrometry method for structural determination of oligosaccharides
Jung-Lee Lin (林俊利, 中研院基因體中心) : Rapid glyco-epitopes analysis of glycoconjugates by liquid chromatography-mass spectrometry
Todd Lowary (University of Alberta): Insight into the immune response arising from mycobacterial infection facilitated by a glycan array
ST Danny Hsu (徐尚德, 中研院生化所) : Cryo-EM and MS Analysis of a Coronavirus Spike Protein Reveals a Unique Structure and Camouflaging Glycans
Yi-Ling Lin (林宜玲, 中研院生醫所) :The role of DC-SIGN in Japanese encephalitis virus infection
Trai-Ming Yeh (葉才明, 成功大學醫學院) : Macrophage migration inhibitory factor is critical for dengue NS1-induced endothelial glycocalyx degradation & hyperpermeability.
Fang-Yen Li (李芳諺, 劉扶東實驗室, 中研院生醫所) : Helicobacter pylori induces intracellular Galectin-8 aggregation around damaged lysosomes.
Chun-Hung Lin (林俊宏, 中研院生化所) : Two host-microbe interplay stories: Xenobiotics glucuronidation and LPS modification/binding
Hung-Lin Chen (陳宏霖, 劉扶東實驗室, 中研院生醫所) : Deciphering host-microbe interaction using GBPs (Glycan-Binding Proteins): Opportunities for decoding big clinical data on human colorectal cancer.
1.Cancer and Stem Cells
John Yu (游正博, 林口長庚紀念醫院) : New paradigm for alveolar structural changes in lung disorders mediated by core fucosylated protein(s) in lung stem cells
Cheng-Feng Tu (凃瀞芬, 楊瑞彬實驗室, 中研院生醫所) : Quantitative proteomic analyses identify novel FUT8 targets and signaling pathways critical for breast cancer cell invasiveness
Tzu-Wen Lin (林子文, 翁啟惠實驗室, 中研院基因體中心) :Dissecting N-glycosylation changes in tumor cells
Yi-Ju Chen (陳誼如，陳玉如實驗室, 中研院化學所) : Decoding site-specific alteration of Sialo-glycoproteome in EGFR-subtype of non-small cell lung cancer
Shye-Ting Chen (陳學亭, 黃敏銓實驗室, 台大醫學院) :
Functional roles of mucin-type O-glycosylation in gastric cancer
Tzu-Hui Hsu (徐子惠, 林國儀實驗室, 中研院基因體中心) :Galectin-8 mitigates the progression of colorectal cancer
2.Immunology and Imflammation
Ivan Dzhagalov (陽明大學微免所) :The role of Heparan sulfate in thymus organogenesis and T cell development
Ming-Wei Chien (簡明偉, 司徒惠康實驗室, 國防醫學院) : Enhanced N-glycan branching on CD8 T cells exacerbates autoimmune diabetes in non-obese diabetic mice
Jian Jing Siew (蕭建靖, 陳儀莊實驗室, 中研院生醫所) : Galectin-3 is required for the cell-autonomous microglial inflammation in Huntington’s disease
Hsiang-Chi Huang (黃湘琦, Reiji Kannagi’s Lab, 中研院生醫所) : NF-kappaB triggers epigenetic silencing of synthesis immunosuppressive Siglec ligand glycans by EZH2/YY1 axis in early-stage colon cancers
Takashi Angata (中研院生化所) : Roles of Siglec-7 ligands in B cell leukemia
