Publications

2025

40. Seung Jae Huh, Yujin Han, Jinkyu Lee, Eunji Park, Se-Hwan Lee, Jinwoo Na, Su Chin Heo, Heungsoo Shin*

"Facile Decellularization of Stem Cell Spheroids by Integrating Bioactive Nanofibers for Enhanced Wound Healing"

Small, 21, e06500, 2025

39. Hyewoo Jeong, Hayeon Byun, Jinkyu Lee*, Yujin Han, Seung Jae Huh, Heungsoo Shin*

"Enhancement of Bone Tissue Regeneration with Multi-Functional Nanoparticles by Coordination of Immune, Osteogenic, and Angiogenic Responses"

Advanced Healthcare Materials, 14 (5), 2400232, 2025

2024

38. Eunhyung Kim, Jinkyu Lee*, Se-Jeong Kim, Eun Mi Kim, Hayeon Byun, Seung Jae Huh, Eunjin Lee, Heungsoo Shin*

"Biomimetic composite gelatin methacryloyl hydrogels for improving survival and osteogenesis of human adipose-derived stem cells in 3D microenvironment"

Materials Today Bio, 29, 101293, 2024

37. Hayeon Byun, Yujin Han, Eunhyung Kim, Indong Jun, Jinkyu Lee, Hyewoo Jeong, Seung Jae Huh, Jinmyoung Joo, Su Ryon Shin, Heungsoo Shin*

"Cell-homing and immunomodulatory composite hydrogels for effective wound healing with neovascularization"

Bioactive materials, 36, 185-202, 2024

36. Sangmin Lee, Jeongbok Lee, Soomi Choi, Eunhyung Kim, Hyunseok Kwon, Jinkyu Lee, Sung Min Kim, Heungsoo Shin*

"Biofabrication of 3D adipose tissue via assembly of composite stem cell spheroids containing adipo-inductive dual-signal delivery nanofibers"

Biofabrication, 16 (3), 035018, 2024

35. Hyunseok Kwon, Sangmin Lee, Hayeon Byun, Seung Jae Huh, Eunjin Lee, Eunhyung Kim, Jinkyu Lee*, Heungsoo Shin*

"Engineering pre-vascularized 3D tissue and rapid vascular integration with host blood vessels via co-cultured spheroids-laden hydrogel"

Biofabrication, 16 (2), 025029, 2024

34. Jinkyu Lee*, Eunjin Lee, Seung Jae Huh, Jeon Il Kang, Kyung Min Park, Hayeon Byun, Sangmin Lee, Eunhyung Kim, Heungsoo Shin*

"Composite spheroid-laden bilayer hydrogel for engineering three-dimensional osteochondral tissue"

Tissue Engineering Part A, 30 (5-6), 225-243, 2024

2023

33. Byun Hayeon, Jang Gyu Nam, Jeong Hyewoo, Lee Jinkyu, Huh Seung Jae, Lee Sangmin, Kim Eunhyung, Shin Heungsoo*

"Development of a composite hydrogel incorporating anti-inflammatory and osteoinductive nanoparticles for effective bone regeneration"

Biomaterials Research, 27, 132, 2023

2022

32. Sangmin Lee, Soomi Choi, Hayeon Byun, Jinkyu Lee, Hyunseok Kwon, Heungsoo Shin*

"Composite multicellular spheroids containing fibers with pores and epigallocatechin gallate (EGCG) coating on the surface for enhanced proliferation of stem cells"

Macromolecular Bioscience, 22 (12), 2200195, 2022

31. Jinkyu Lee*, Seung Jae Huh, Ji Min Seok, Sangmin Lee, Hayeon Byun, Gyu Nam Jang, Eunhyung Kim, Se-jeong Kim, Su A Park, Sung Min Kim, Heungsoo Shin*

"Surface engineering of 3D-printed scaffolds with minerals and a pro-angiogenic factor for vascularized bone regeneration"

Acta Biomaterialia, 140, 730-744, 2022

30. Jinkyu Lee*, Seoyun Lee, Seung Jae Huh, Byung‐Jae Kang, Heungsoo Shin*

"Directed regeneration of osteochondral tissue by hierarchical assembly of spatially organized composite spheroids"

Advanced Science, 9 (3), 2103525, 2022

2021

29. Jinkyu Lee*, Sangmin Lee, Sung Min Kim, Heungsoo Shin*

"Size-controlled human adipose-derived stem cell spheroids hybridized with single-segmented nanofibers and their effect on viability and stem cell differentiation"

Biomaterials Research, 25 (1), 14, 2021

28. Hayeon Byun, Gyu Nam Jang, Jinkyu Lee, Min-Ho Hong, Hyunjung Shin, Heungsoo Shin*

"Stem cell spheroid engineering with osteoinductive and ROS scavenging nanofibers for bone regeneration"

Biofabrication, 13 (3), 034101, 2021

27. Sangmin Lee, Jinkyu Lee, Hayeon Byun, Se-jeong Kim, Jinmyoung Joo, Hee Ho Park, Heungsoo Shin*

"Evaluation of the anti-oxidative and ROS scavenging properties of biomaterials coated with epigallocatechin gallate for tissue engineering"

Acta Biomaterialia, 124, 166-178, 2021

2020

26. Jinkyu Lee*, Ji Min Seok, Seung Jae Huh, Hayeon Byun, Sangmin Lee, Su A Park, Heungsoo Shin*

"3D printed micro-chambers carrying stem cell spheroids and pro-proliferative growth factors for bone tissue regeneration"

Biofabrication, 13 (1), 015011, 2020

25. Jinkyu Lee*, Jinki Lee, Sangmin Lee, Taufiq Ahmad, Sajeesh Kumar Madhurakkat Perikamana, Eun Mi Kim, Sang Won Lee, Heungsoo Shin*

"Bioactive membrane immobilized with lactoferrin for modulation of bone regeneration and inflammation"

Tissue Engineering Part A, 26 (23-24), 1243-1258, 2020

24. Jinkyu Lee*, Sangmin Lee, Taufiq Ahmad, Sajeesh Kumar Madhurakkat Perikamana, Jinki Lee, Eun Mi Kim, Heungsoo Shin*

"Human adipose-derived stem cell spheroids incorporating platelet-derived growth factor (PDGF) and bio-minerals for vascularized bone tissue engineering"

Biomaterials, 255, 120192, 2020

23. Taufiq Ahmad, Hayeon Byun, Jinkyu Lee, Sajeesh Kumar Madhurakat Perikamana, Young Min Shin, Eun Mi Kim, Heungsoo Shin*

"Stem cell spheroids incorporating fibers coated with adenosine and polydopamine as a modular building blocks for bone tissue engineering"

Biomaterials, 230, 119652, 2020

22. Taufiq Ahmad, Hayeon Byun, Hyeok Jun Shin, Jinkyu Lee, Sajeesh Kumar Madhurakkat Perikamana, Eun Mi Kim, Young Min Shin, Heungsoo Shin*

"Polydopamine-assisted one-step modification of nanofiber surfaces with adenosine to tune the osteogenic differentiation of mesenchymal stem cells and the maturation of osteoclasts"

Biomaterials Science, 8 (10), 2825-2839, 2020

21. Sangmin Lee, Yun-Young Chang, Jinkyu Lee, Sajeesh Kumar Madhurakkat Perikamana, Eun Mi Kim, Yang-Hun Jung, Jeong-Ho Yun, Heungsoo Shin*

"Surface engineering of titanium alloy using metal-polyphenol network coating with magnesium ions for improved osseointegration"

Biomaterials Science, 8 (12), 3404-3417, 2020

2019

20. Sajeesh Kumar Madhurakkat Perikamana, Jinkyu Lee, So Yeon Park, Hyun Suk Jung, Heungsoo Shin*

"Effect of gradient biomineral concentrations on osteogenic and chondrogenic differentiation of adipose derived stem cells"

Journal of Industrial and Engineering Chemistry, 80, 784-794, 2019

19. Eun Mi Kim, Yu Bin Lee, Se-jeong Kim, Jaesung Park, Jinkyu Lee, Sung Won Kim, Hansoo Park, Heungsoo Shin*

"Fabrication of core-shell spheroids as building blocks for engineering 3D complex vascularized tissue"

Acta Biomaterialia, 100, 158-172, 2019

18. Sungjun Kim, Jinkyu Lee*, Mintai P Hwang, Yadong Wang, Kyobum Kim*

"Influence of fiber architecture and growth factor formulation on osteoblastic differentiation of mesenchymal stem cells in coacervate-coated electrospun fibrous scaffolds"

Journal of Industrial and Engineering Chemistry, 79, 236-244, 2019

17. Sajeesh Kumar Madhurakkat Perikamana, Sang Min Lee, Jinkyu Lee, Taufiq Ahmad, Min Suk Lee, Hee Seok Yang, Heungsoo Shin*

"Oxidative epigallocatechin gallate coating on polymeric substrates for bone tissue regeneration"

Macromolecular Bioscience, 19 (4), 1800392, 2019

16. Jinkyu Lee*, Hayeon Byun, Sajeesh Kumar Madhurakkat Perikamana, Sangmin Lee, Heungsoo Shin*

"Current advances in immunomodulatory biomaterials for bone regeneration"

Advanced healthcare materials, 8 (4), 1801106, 2019

2018

15. Taufiq Ahmad, Young Min Shin, Jinkyu Lee, Hyeok Jun Shin, Sajeesh Kumar Madhurakart Perikamana, Heungsoo Shin*

"Agglomeration of human dermal fibroblasts with ECM mimicking nano-fragments and their effects on proliferation and cell/ECM interactions"

Journal of Industrial and Engineering Chemistry, 67, 80-91, 2018

14. Taufiq Ahmad, Hyeok Jun Shin, Jinkyu Lee, Young Min Shin, Sajeesh Kumar Madhurakat Perikamana, So Yeon Park, Hyun Suk Jung, Heungsoo Shin*

"Fabrication of in vitro 3D mineralized tissue by fusion of composite spheroids incorporating biomineral-coated nanofibers and human adipose-derived stem cells"

Acta biomaterialia, 74, 464-477, 2018

13. Sajeesh Kumar Madhurakkat Perikamana, Jinkyu Lee, Taufiq Ahmad, Eun Mi Kim, Hayeon Byun, Sangmin Lee, Heungsoo Shin*

"Harnessing biochemical and structural cues for tenogenic differentiation of adipose derived stem cells (ADSCs) and development of an in vitro tissue interface mimicking tendon-bone insertion graft"

Biomaterials, 165 (79-93), 2018

2017

12. Taufiq Ahmad, Jinkyu Lee*, Young Min Shin, Hyeok Jun Shin, Sajeesh Kumar Madhurakat Perikamana, Sun Hwa Park, Sung Won Kim, Heungsoo Shin*

"Hybrid-spheroids incorporating ECM like engineered fragmented fibers potentiate stem cell function by improved cell/cell and cell/ECM interactions"

Acta biomaterialia, 64, 161-175, 2017

11. Sajeesh Kumar Madhurakkat Perikamana, Young Min Shin, Jinkyu Lee, Yu Bin Lee, Yunhoe Heo, Taufiq Ahmad, So Yeon Park, Jisoo Shin, Kyung Min Park, Hyun Suk Jung, Seung-Woo Cho, Heungsoo Shin*

"Graded functionalization of biomaterial surfaces using mussel-inspired adhesive coating of polydopamine"

Colloids and Surfaces B: Biointerfaces, 150, 546-556, 2017

10. Indong Jun, Taufiq Ahmad, Seongwoo Bak, Joong‐Yup Lee, Eun Mi Kim, Jinkyu Lee, Yu Bin Lee, Hongsoo Jeong, Hojeong Jeon, Heungsoo Shin*

"Spatially assembled bilayer cell sheets of stem cells and endothelial cells using thermosensitive hydrogels for therapeutic angiogenesis"

Advanced healthcare materials, 6 (9), 1601340, 2017

9. Min Suk Lee, Taufiq Ahmad, Jinkyu Lee, Hassan K Awada, Yadong Wang, Kyobum Kim, Heungsoo Shin, Hee Seok Yang*

"Dual delivery of growth factors with coacervate-coated poly (lactic-co-glycolic acid) nanofiber improves neovascularization in a mouse skin flap model"

Biomaterials, 124, 65-77, 2017

8. Jinkyu Lee*, Sajeesh Kumar Madhurakkat Perikamana, Taufiq Ahmad, Min Suk Lee, Hee Seok Yang, Do-Gyoon Kim, Kyobum Kim, Bosun Kwon, Heungsoo Shin*

"Controlled retention of BMP-2-derived peptide on nanofibers based on mussel-inspired adhesion for bone formation"

Tissue Engineering Part A, 23 (7-8), 323-334, 2017

7. Sajeesh Kumar Madhurakkat Perikamana, Jinkyu Lee, Young Min Shin, Taufiq Ahmad, Se-jeong Kim, Kyung Min Park, Heungsoo Shin*

"Oxygen-dependent generation of a graded polydopamine coating on nanofibrous materials for controlling stem cell functions"

Journal of Materials Chemistry B, 5 (44), 8865-8878, 2017

6. Jisoo Shin, Jung Ho Cho, Yoonhee Jin, Kisuk Yang, Jong Seung Lee, Hyun‐Ji Park, Hyung‐Seop Han, Jinkyu Lee, Hojeong Jeon, Heungsoo Shin, Seung Woo Cho*

"Mussel adhesion-inspired reverse transfection platform enhances osteogenic differentiation and bone formation of human adipose‐derived stem cells"

Small, 12 (45), 6266-6278, 2016

2016

5. Yu Bin Lee, Joong-Yup Lee, Taufiq Ahmad, Seongwoo Bak, Jinkyu Lee, Hwan D Kim, Tai Hyun Park, Nathaniel S Hwang, Youn Mook Lim, Heungsoo Shin*

"Construction of 3-D Cellular Multi-Layers with Extracellular Matrix Assembly Using Magnetic Nanoparticles"

Journal of Biomedical Nanotechnology, 12 (10), 1916-1928, 2016

2015

4. Sajeesh Kumar Madhurakkat Perikamana, Jinkyu Lee*, Yu Bin Lee, Young Min Shin, Esther J Lee, Antonios G Mikos, Heungsoo Shin 

"Materials from mussel-inspired chemistry for cell and tissue engineering applications"

Biomacromolecules, 16 (9), 2541-2555, 2015

3. Boram Son, Hwan D Kim, Minsoo Kim, Jeong Ah Kim, Jinkyu Lee, Heungsoo Shin, Nathaniel S Hwang, Tai Hyun Park 

"Physical Stimuli-Induced Chondrogenic Differentiation of Mesenchymal Stem Cells Using Magnetic Nanoparticles"

Advanced healthcare materials, 4 (9), 1339-1347, 2015

2. Sajeesh Kumar Madhurakkat Perikamana, Jinkyu Lee, Taufiq Ahmad, Yonghoon Jeong, Do-Gyoon Kim, Kyobum Kim, Heungsoo Shin

"Effects of immobilized BMP-2 and nanofiber morphology on in vitro osteogenic differentiation of hMSCs and in vivo collagen assembly of regenerated bone"

ACS applied materials & interfaces, 7 (16), 8798-8808, 2015

2014

1. Hyeong-jin Cho, Sajeesh Kumar Madhurakkat Perikamana, Ji-hye Lee, Jinkyu Lee, Kyung-Mi Lee, Choongsoo S Shin, Heungsoo Shin

"Effective immobilization of BMP-2 mediated by polydopamine coating on biodegradable nanofibers for enhanced in vivo bone formation"

ACS applied materials & interfaces, 6 (14), 11225-11235, 2014