This interdisciplinary meeting brings together researchers exploring the multifaceted phenomenon of cell plasticity through systems-level approaches. The meeting highlights advances in understanding how gene regulatory networks, signaling dynamics, epigenetic states, and microenvironmental cues collectively shape cellular identity and transitions. Featuring leading scientists from across the globe, the symposium integrates theoretical modeling, computational frameworks, and experimental studies aimed at uncovering the emergent principles that govern cellular flexibility and state changes in health and disease.