Publications

12. Lee SY†, Roh H†, Gonzalez-Perez D, Mackey MR, Hoces D, McLaughlin CN, Lin C, Adams SR, Nguyen K, Kim KY, Luginbuhl DJ, Luo L, Udesh ND, Carr SA, Hernandez-Lopez RA, Ellisman MH, Alcalde M, and Ting AY*.  Directed evolution of LaccID for cell surface proximity labeling and EM. Nature Chemical Biology, 2025, Accepted (†equally contributed) 

11. Shin SH†, Lee SY†, Kang MG, Jang DG, Kim JS, Rhee HW* and Kim JS* (2024). Super-resolution proximity labeling with enhanced direct identification of biotinylation sites. Communications Biology, 2024, 7, 554.(†equally contributed) 

10.  Lee A†, Sung GH†, Shin SH, Lee SY, Sim JH, Nhung TTM, Nghi TD, Park SK, Sathieshkumar PP, Kang IK, Mun JY, Kim JS*, Rhee HY*, Park KM*, and Kim KM*, OrthoID: profiling dynamic proteomes through time and space using mutually orthogonal chemical tools, Nature commun, 2024, 15, 1851. 

9. Lee SY†, Cheah JS†, Zhao B, Xu C, Roh HG, Kim CK, Cho KF, Udeshi ND, Carr SA, and Ting AY. Engineered allostery in light-regulated LOV-Turbo enables precise spatiotemporal control of proximity labeling in living cells. Nature Methods  2023, 20, 908-917. (†equally contributed). 

8.     Yun SI, Kwak C, Lee SY, Shin S, Oh C, Kim JS, Rhee HW*, Kim KK*. Binding of USP4 to cortactin enhances cell migration in HCT116 human colon cancer cells.  FASEB J. 2023 , 37, e22900. 

7.     Beon J, Han S, Yang H, Park SE, Hyun K, Lee SY, Rhee HW, Seo JK, Kim J, Kim S*, Lee D* Inositol polyphosphate multikinase physically binds to the SWI/SNF complex and modulates BRG1 occupancy in mouse embryonic stem cells. Elife. 2022, 11: e73523. 

6.     Sung G, Lee SY, Kang MG, Kim KL, An J, Sim J, Kim S, Kim S, Ko J, Rhee HW*, Park KM*, Kim K*, Supra-blot: an accurate and reliable assay for detecting target proteins with a synthetic host molecule-enzyme hybrid. Chem. Commun. 2020, 56, 1549-1552.

5.     Van Haute L, Lee SY, McCann BJ, Powell CA, Bansal D, Vasiliauskaitė L, Garone C, Shin S, Kim JS, Frye M, Gleeson JG, Miska EA, Rhee HW, Minczuk M* NSUN2 introduces 5-methylcytosines in mammalian mitochondrial tRNAs. Nucleic Acids Res. 2019, 47, 8720-8733

4. Park J†, Lee SY†, Jeong H, Kang MG, Haute L, Minczuk M, Seo JK, Jun Y, Myung K, Rhee HW*, Lee C*, The structure of human EXD2 reveals a chimeric 3′ to 5′ exonuclease domain that discriminates substrates via metal coordination., Nucleic Acid Res. 2019, 47, 7078-7093 (†equally contributed)

3. Lee SY, Kang MG, Shin S, Kwak C, Kwon T, Seo JK*, Kim JS*, Rhee HW*, Architecture Mapping of the Inner Mitochondrial Membrane Proteome by Chemical Tools in Live Cells, J. Am. Chem. Soc., 2017, 139, 3651-3662.

2. Lee SY†, Lee H†, Lee HK, Lee SW, Ha SC, Kwon T, Seo JK*, Lee C*, Rhee HW*, Proximity-Directed Labeling Reveals a New Rapamycin-Induced Heterodimer of FKBP25 and FRB in Live Cells, ACS Cent. Sci., 2016, 2, 506-516 (†equally contributed).

1. Lee SY, Kang MG, Park JS, Lee G, Ting AY*, Rhee HW*, APEX Fingerprinting Reveals the Subcellular Localization of Proteins of Interest, Cell Rep. 2016, 15, 1837-1847. 

[Book chapter]

1.     Lee SY, Seo JK, Rhee HW* Direct Identification of Biotinylated Proteins from Proximity Labeling (Spot-BioID) , Methods Mol. Biol. 2019 , 97-105 (Invited Book Chapter)