Publications

All Publications

1. Song, H., Yun, C., Choi, Y. et al. Urolithin A activates mitophagy via the AMPK–mTOR axis and modulates the gut–ceramide axis to ameliorate cardiac remodeling in HFpEF. Exp Mol Med (2026). https://doi.org/10.1038/s12276-026-01776-2  

2. Jeong, J., Choi, Y., Sa, Y. et al. M-CSF priming enhances the efficiency and reproducibility of hiPSC-derived osteoclast differentiation and pharmacological responsiveness to anti-resorptive agents. Sci Rep 16, 22350 (2026). https://doi.org/10.1038/s41598-026-52457-z  

3. Oh, J., Kwon, O.-B., Park, S.-W. et al. Advancing cardiovascular drug screening using human pluripotent stem cell-derived cardiomyocytes. Int J Mol Sci 25, 7971 (2024). https://doi.org/10.3390/ijms25147971  

4. Lee, JH., Geem, K.R., Chen, Z. et al. In planta production of human-derived RANKL. Plant Biotechnol Rep 18, 579–585 (2024). https://doi.org/10.1007/s11816-024-00917-1  

5. Chen, Z., Yao, H., Encarnacion, A.M. et al. Novel inhibitor of Keap1-Nrf2 protein–protein interaction attenuates osteoclastogenesis in vitro and prevents OVX-induced bone loss in vivo. Antioxidants 13, 850 (2024). https://doi.org/10.3390/antiox13070850  

6. Chen, Z., Choi, E.R., Encarnacion, A.M. et al. Discovery of TCP-(MP)-caffeic acid analogs as a new class of agents for treatment of osteoclastic bone loss. Bioorg Chem 150, 107603 (2024). https://doi.org/10.1016/j.bioorg.2024.107603 

7. Liang, D., Mikhalchenko, A., Ma, H. et al. Limitations of gene editing assessments in human preimplantation embryos. Nat Commun 14, 1219 (2023). https://doi.org/10.1038/s41467-023-36820-6  

8. Jeong, J., Lee, D., Park, B.-C. et al. Establishment of a TNFRSF11B knock-out human induced pluripotent stem cell line (KSCBi002-B-2) via CRISPR/Cas9 system. Stem Cell Res 71, 103167 (2023). https://doi.org/10.1016/j.scr.2023.103167  

9. Ding, M., Cho, E., Chen, Z. et al. (S)-2-(Cyclobutylamino)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)isonicotinamide attenuates RANKL-induced osteoclast differentiation by inhibiting NF-κB nuclear translocation. Int J Mol Sci 24, 4327 (2023). https://doi.org/10.3390/ijms24054327  

10. Ding, M., Chen, Z., Cho, E. et al. Crucial role of lysine-specific histone demethylase 1 in RANKL-mediated osteoclast differentiation. Int J Mol Sci 24, 3605 (2023). https://doi.org/10.3390/ijms24043605  

11. Chen, Z., Rajamanickam, K.R., Ding, M. et al. Discovery of PMSA derivative 11 as a novel lead compound for therapeutic treatment of osteoporosis in vitro and in vivo. J Med Chem 66, 6766–6781 (2023). https://doi.org/10.1021/acs.jmedchem.3c00114  (2023 JCI percentile =99.31)

12. Chen, Z., Joseph, D., Ding, M. et al. Synthesis and evaluation of 2-NMPA derivatives as potential agents for prevention of osteoporosis in vitro and in vivo. Eur J Med Chem 260, 115767 (2023). https://doi.org/10.1016/j.ejmech.2023.115767  

13. Cho, E., Cheon, S., Ding, M. et al. Identification of novel genes for cell fusion during osteoclast formation. Int J Mol Sci 23, 6421 (2022). https://doi.org/10.3390/ijms23126421  

14. Choi, D.-K., Kim, Y.-K., Yu, J.H. et al. Chapter eleven - Genome editing of hPSCs: Recent progress in hPSC-based disease modeling for understanding disease mechanisms. Prog Mol Biol Transl Sci 181, 271–287 (2021). https://doi.org/10.1016/bs.pmbts.2021.01.020  

15. Kim, Y.-K., Yu, J.H., Min, S.-H. et al. Generation of a GLA knock-out human-induced pluripotent stem cell line, KSBCi002-A-1, using CRISPR/Cas9. Stem Cell Res 42, 101676 (2020). https://doi.org/10.1016/j.scr.2019.101676 

16. Do, H.S., Park, S.W., Im, I. et al. Enhanced thrombospondin-1 causes dysfunction of vascular endothelial cells derived from Fabry disease-induced pluripotent stem cells. EBioMedicine 52, 102633 (2020). https://doi.org/10.1016/j.ebiom.2020.102633 (2020 IF=8.143 ,1st author)

17. Choi, D.K., Kim, Y.K., Park, S.W. et al. The histone lysine methyltransferase SETD8 regulates angiogenesis through HES-1 in human umbilical vein endothelial cells. Sci Rep 10, 12117 (2020). https://doi.org/10.1038/s41598-020-69103-x  

18. Ma, H., Marti-Gutierrez, N., Park, SW. et al. Ma et al. reply. Nature 560, E10–E23 (2018). https://doi.org/10.1038/s41586-018-0381-y  

19. Ma, H., Marti-Gutierrez, N., Park, SW. et al. Correction of a pathogenic gene mutation in human embryos. Nature 548, 413–419 (2017). https://doi.org/10.1038/nature23305 (2017 IF= 41.577, 1st author)

20. Kim, Y., Kim, N., Park, S. et al. Lineage-specific expression of miR-200 family in human embryonic stem cells during in vitro differentiation. Int J Stem Cells 10, 28–37 (2017). https://doi.org/10.15283/ijsc17013  

21. Park, S.W., Kim, J., Park, J.L. et al. Variable allelic expression of imprinted genes in human pluripotent stem cells during differentiation into specialized cell types in vitro. Biochem Biophys Res Commun 446, 493–498 (2014). https://doi.org/10.1016/j.bbrc.2014.02.141  

22. Park, S.W., Do, H.S., Kim, D. et al. Transcriptional profiles of imprinted genes in human embryonic stem cells during in vitro differentiation. Int J Stem Cells 7, 108–117 (2014). ttps://doi.org/10.15283/ijsc.2014.7.2.108   

23. Kim, S.-K., Lee, H., Han, K. et al. SET7/9 methylation of the pluripotency factor LIN28A is a nucleolar localization mechanism that blocks let-7 biogenesis in human ESCs. Cell Stem Cell 15, 735–749 (2014). https://doi.org/10.1016/j.stem.2014.10.016 (2014 IF=13.903)

24. Joo, H.J., Kim, H., Park, S.-W. et al. Angiopoietin-1 promotes endothelial differentiation from embryonic stem cells and induced pluripotent stem cells. Blood 118, 2094–2104 (2011). https://doi.org/10.1182/blood-2010-12-323907 (2011 IF=9.743)

25. Park, S.-W., Koh, Y.J., Jeon, J. et al. Efficient differentiation of human pluripotent stem cells into functional CD34+ progenitor cells by combined modulation of the MEK/ERK and BMP4 signaling pathways. Blood 116, 5762–5772 (2010). https://doi.org/10.1182/blood-2010-04-280719 (2010 IF=10.558 , 1st author)