Publications

Featured Publication

1. Chen, Z. et al. Discovery of PMSA Derivative 11 as a Novel Lead Compound for Therapeutic Treatment of Osteoporosis In Vitro and In Vivo. J Med Chem 66, 6766-6781, doi:10.1021/acs.jmedchem.3c00114 (2023).(2023 JCI percentile =99.31)

2. Do, H. S. et al. Enhanced thrombospondin-1 causes dysfunction of vascular endothelial cells derived from Fabry disease-induced pluripotent stem cells. EBioMedicine 52, 102633,(2020). (2023 IF=9.7 ,1st author)

3. Ma, H. et al. Correction of a pathogenic gene mutation in human embryos. Nature 548, 413-419, (2017). (2023 IF= 50.5, 1st author)

4. Kim, S. K. et al. SET7/9 methylation of the pluripotency factor LIN28A is a nucleolar localization mechanism that blocks let-7 biogenesis in human ESCs. Cell Stem Cell 15, 735-749, doi:10.1016/j.stem.2014.10.016 (2014). (2023 IF=19.8)

5. Joo, H. J. et al. Angiopoietin-1 promotes endothelial differentiation from embryonic stem cells and induced pluripotent stem cells. Blood 118, 2094-2104, doi:10.1182/blood-2010-12-323907 (2011). (2023 IF=21.0)

6. Park, S. W. et al. Efficient differentiation of human pluripotent stem cells into functional CD34+ progenitor cells by combined modulation of the MEK/ERK and BMP4 signaling pathways. Blood 116, 5762-5772, (2010). (2023 IF=21.0 , 1st author)

All Publications

1. Oh, J. et al. Advancing Cardiovascular Drug Screening Using Human Pluripotent Stem Cell-Derived Cardiomyocytes. Int J Mol Sci 25 (2024).

2. Lee, J.H. et al. production of human-derived RANKL. Plant Biotechnol Rep 18, 579-585 (2024).

3. Chen, Z. et al. Novel Inhibitor of Keap1-Nrf2 Protein-Protein Interaction Attenuates Osteoclastogenesis In Vitro and Prevents OVX-Induced Bone Loss In Vivo. Antioxidants (Basel) 13 (2024).

4. Chen, Z. et al. Discovery of TCP-(MP)-caffeic acid analogs as a new class of agents for treatment of osteoclastic bone loss. Bioorg Chem 150 (2024).

5. Liang, D. et al. Limitations of gene editing assessments in human preimplantation embryos. Nat Commun 14, 1219, doi:10.1038/s41467-023-36820-6 (2023).

6. Jeong, J., Lee, D., Park, B. C., Lee, T. H. & Park, S. W. Establishment of a TNFRSF11B knock-out human induced pluripotent stem cell line (KSCBi002-B-2) via CRISPR/Cas9 system. Stem Cell Res 71, 103167, doi:10.1016/j.scr.2023.103167 (2023).

7. Ding, M., Cho, E., Chen, Z., Park, S. W. & Lee, T. H. (S)-2-(Cyclobutylamino)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)isonicotinamide Attenuates RANKL-Induced Osteoclast Differentiation by Inhibiting NF-kappaB Nuclear Translocation. Int J Mol Sci 24, doi:10.3390/ijms24054327 (2023).

8. Ding, M., Chen, Z., Cho, E., Park, S. W. & Lee, T. H. Crucial Role of Lysine-Specific Histone Demethylase 1 in RANKL-Mediated Osteoclast Differentiation. Int J Mol Sci 24, doi:10.3390/ijms24043605 (2023).

9. Chen, Z. et al. Discovery of PMSA Derivative 11 as a Novel Lead Compound for Therapeutic Treatment of Osteoporosis In Vitro and In Vivo. J Med Chem 66, 6766-6781, doi:10.1021/acs.jmedchem.3c00114 (2023).

10. Chen, Z. et al. Synthesis and evaluation of 2-NMPA derivatives as potential agents for prevention of osteoporosis in vitro and in vivo. Eur J Med Chem 260, 115767, doi:10.1016/j.ejmech.2023.115767 (2023).

11. Cho, E. et al. Identification of Novel Genes for Cell Fusion during Osteoclast Formation. Int J Mol Sci 23, doi:10.3390/ijms23126421 (2022).

12. Choi, D. K., Kim, Y. K., HoonYu, J., Min, S. H. & Park, S. W. Genome editing of hPSCs: Recent progress in hPSC-based disease modeling for understanding disease mechanisms. Prog Mol Biol Transl Sci 181, 271-287, doi:10.1016/bs.pmbts.2021.01.020 (2021).

13. Kim, Y. K., Yu, J. H., Min, S. H. & Park, S. W. Generation of a GLA knock-out human-induced pluripotent stem cell line, KSBCi002-A-1, using CRISPR/Cas9. Stem Cell Res 42, 101676, doi:10.1016/j.scr.2019.101676 (2020).

14. Do, H. S. et al. Enhanced thrombospondin-1 causes dysfunction of vascular endothelial cells derived from Fabry disease-induced pluripotent stem cells. EBioMedicine 52, 102633, doi:10.1016/j.ebiom.2020.102633 (2020).

15. Choi, D. K. et al. The histone lysine methyltransferase SETD8 regulates angiogenesis through HES-1 in human umbilical vein endothelial cells. Sci Rep 10, 12089, doi:10.1038/s41598-020-69103-x (2020).

16. Ma, H. et al. Ma et al. reply. Nature 560, E10-E23, doi:10.1038/s41586-018-0381-y (2018).

17. Ma, H. et al. Correction of a pathogenic gene mutation in human embryos. Nature 548, 413-419, doi:10.1038/nature23305 (2017).

18. Kim, Y. et al. Lineage-specific Expression of miR-200 Family in Human Embryonic Stem Cells during In Vitro Differentiation. Int J Stem Cells 10, 28-37, doi:10.15283/ijsc17013 (2017).

19. Park, S. W. et al. Variable allelic expression of imprinted genes in human pluripotent stem cells during differentiation into specialized cell types in vitro. Biochem Biophys Res Commun 446, 493-498, doi:10.1016/j.bbrc.2014.02.141 (2014).

20. Park, S. W. et al. Transcriptional Profiles of Imprinted Genes in Human Embryonic Stem Cells During In vitro Differentiation. Int J Stem Cells 7, 108-117, doi:10.15283/ijsc.2014.7.2.108 (2014).

21. Kim, S. K. et al. SET7/9 methylation of the pluripotency factor LIN28A is a nucleolar localization mechanism that blocks let-7 biogenesis in human ESCs. Cell Stem Cell 15, 735-749, doi:10.1016/j.stem.2014.10.016 (2014).

22. Joo, H. J. et al. Angiopoietin-1 promotes endothelial differentiation from embryonic stem cells and induced pluripotent stem cells. Blood 118, 2094-2104, doi:10.1182/blood-2010-12-323907 (2011).

23. Park, S. W. et al. Efficient differentiation of human pluripotent stem cells into functional CD34+ progenitor cells by combined modulation of the MEK/ERK and BMP4 signaling pathways. Blood 116, 5762-5772, doi:10.1182/blood-2010-04-280719 (2010)