Research

We have developed a photoinduced transition metal-free decarbonylative strategy at ambient temperature through the non-covalent interaction to achieve vinyl sulfones. Traditionally decarbonylative functionalization accomplished using transition metal catalysts at elevated temperatures. The π-π interaction facilitates the elimination of CO to generate vinyl radical, therefore promoting the creation of C-S bonds with sulfonyl radical. These interactions and the overall process have been illuminated by spectroscopic investigations and mechanistic studies. Link 

We report an organo-photocatalyzed carboacylation reaction that offers a springboard to create chemical complexity in a diversity-driven approach. The modular one-pot method uses feedstock aldehydes and alcohols as acyl surrogates and commercially available EosinY as the photoredox catalyst, making it simple and affordable to introduce structural diversity. Several biologically relevant skeletons have been easily synthesized under mild conditions in the presence of visible light irradiation by fostering a radical acylation/ cyclization cascade. The proposed reaction mechanism was further illuminated by a number of spectroscopic studies. Furthermore, we applied this protocol for the late-stage functionalization of pharmaceuticals and blockbuster drugs. Link

Photoredox catalysis has demonstrated rapid evolution in the field of synthetic organic chemistry. On the other hand, the splendour of cascade reactions in providing complex molecular architectures renders them a cutting-edge research area. Therefore, the merging of photocatalysis with cascade synthesis brings out a synthetic paradigm with immense potential. The development of photocascade catalysis for a target molecule with a particular molecular skeleton and stereochemical framework presents certain challenges but provides a robust and environmentally benign synthetic alternative. Link