The human metabolome is a sensitive readout of health and disease, shaped by genetics, environment, and lifestyle. Our laboratory develops and applies advanced mass spectrometry to read these molecular signatures with chemical precision. By integrating metabolomics, lipidomics, proteomics, transcriptomics, and exposomics, we connect analytical chemistry to biology—identifying biomarkers, resolving the fine structures of bioactive molecules, and building robust methods for next-generation therapeutics. Our ultimate goal is to translate molecular insight into improved human health.