Allison A Dilliott, Seulki Kwon, Guy A Rouleau, Sumaiya Iqbal*, Sali M K Farhan*.
Characterizing proteomic and transcriptomic features of missense variants in amyotrophic lateral sclerosis genes.
Brain, 2023. PMID: 37394881 DOI: 10.1093/brain/awad224.
Sumaiya Iqbal*, Tobias Brünger, Eduardo Pérez-Palma, Marie Macnee, Andreas Brunklaus, Mark J Daly, Arthur J Campbell, David Hoksza, Patrick May, Dennis Lal*.
Delineation of functionally essential protein regions for 242 neurodevelopmental genes.
Brain, 2023. PMID: 36256779. DOI: 10.1093/brain/awac381
Jaie Woodard, Sumaiya Iqbal, Mashaghi Tabari, A.
Circuit topology predicts pathogenicity of missense mutations.
PROTEINS: Structure, Function, and Bioinformatics, 2022; 90(9):1634-1644. PMID: 35394672. DOI: 10.1002/prot.26342
Peter Miller, Murugappan Sathappa, Jamie Moroco, Wei Jiang, Yue Qian, Sumaiya Iqbal, ..., David Root, Colin Garvie, Benjamin Ebert.
Allosteric inhibition of PPM1D serine/threonine phosphatase via an altered conformational state.
Nature Communication, 2022; 13(1):3778. PMID: 3577325. DOI: 10.1038/s41467-022-30463-9.
Shehab S. Ahmed, Zaara T. Rifat, Ruchi Lohia, Arthur J. Campbell, A. Keith Dunker, M. Sohel Rahman, Sumaiya Iqbal.
Characterization of intrinsically disordered regions in proteins informed by human genetic diversity.
PLOS Computational Biology, 2022; 18(3):e1009911. PMID: 35275927. DOI: 10.1371/journal.pcbi.1009911.
Sumaiya Iqbal, Tobias Brünger, Eduardo Pérez-Palma, David Hoksza, ArthurJ. Campbell, Mark J. Daly, Patrick May, Dennis Lal.
Genomic analysis of AlphaFold2-predicted structures identifies maps of 3D essential sites in 243 neurodevelopmental disorder-associated proteins.
Biophysical Journal (Abstract Issue, Selected for platform talk), 2022; 121 (3), Supp. 1, 165A-166A. DOI: 10.1016/j.bpj.2021.11.1909.
Katrine M Johannesen, Sumaiya Iqbal, ..., Philip K. Ahring, Rikke S. Møller, Elena Gardella.
Structural mapping of GABRB3 variants reveals genotype–phenotype correlations.
Genetic in Medicine, 2021. PMID: 34906499 DOI: 10.1016/j.gim.2021.11.004.
Allan Bayat, Sumaiya Iqbal, Kim Borredy, Jeanne Amiel, Christiane Zweier, Guilia Barcia, Cornelia Kraus, Heike Weyhreter, Alexander G. Bassuk, Maya Chopra, Guido Rubboli & Rikke S. Møller .
PRICKLE2 revisited-further evidence implicating PRICKLE2 in neurodevelopmental disorders.
European Journal of Human Genetics, 2021. PMID: 34092786. DOI: 10.1038/s41431-021-00912-y.
Christelle Moufawad El Achkar, Merle Harrer, Lacey Smith, McKenna Kelley, Sumaiya Iqbal, Snezana Maljevic, Cristina Niturad, Lisenka Vissers, Annapurna Poduri, Edward Yang; Dennis Lal, Holger Lerche, Rikke Møller, Heather Olson.
Characterization of the GABRB2 associated neurodevelopmental disorders.
Annals of Neurology, 89 (3), 573-586, 2021. PMID: 33325057, DOI: 10.1002/ana.25985.
Marco Necci, Damiano Piovesan, CAID Predictors (Md Tamjidul Hoque, Ian Walsh, Sumaiya Iqbal, ...), DisProt Curators & Silvio C. E. Tosatto.
Critical assessment of protein intrinsic disorder prediction.
Nature Methods, volume 18, pages 472–481, 2021. PMID: 33875885. DOI: 10.1038/s41592-021-01117-3.
Rodrigo Mendez, Sumaiya Iqbal, Sebastián Vishnopolska, Cinthia Martinez, Glenda Dibner, Rocio Aliano, Jonathan Zaiat, Germán Biagioli, Cecilia Fernandez, Adrian Turjanski, Arthur J Campbell, Graciela Mercado, Marcelo A Marti.
Oculocutaneous albinism type 1B associated with a functionally significant tyrosinase gene polymorphism detected with Whole Exome Sequencing.
Opthalmic Genetics (Taylor & Francis online), Feb 2021, 1 - 5. PMID: 33599182. DOI: 10.1080/13816810.2021.1888129.
Jon M. Madison, Karen Duong, Ellen F. Vieux, Namrata D. Udeshi, Sumaiya Iqbal, Elise Requadt, Shaunt Fereshetian, Michael C. Lewis, Antonio S. Gomes, Kerry A. Pierce, Randall J. Platt, Feng Zhang, Arthur J. Campbell, Dennis Lal, Florence F. Wagner, Clary B. Clish, Steven A. Carr, Morgan Sheng, Edward M. Scolnick, Jeffrey R. Cottrell.
Regulation of AMP synthesis by a KCTD13 ubiquitin ligase connects 16p11.2 deletion syndrome to a metabolic disorder with autistic features.
iScience (Cell Press), accepted, Dec 2020, 24(1):101935. PMID: 33409479. DOI: 10.1016/j.isci.2020.101935.
Sumaiya Iqbal*, Eduardo Pérez-Palma, Jakob B. Jespersen, Patrick May, David Hoksza, Henrike O. Heyne, Shehab S. Ahmed, Zaara T. Rifat, M. Sohel Rahman, Kasper Lage, Aarno Palotie, Jeffrey R. Cottrell, Florence F. Wagner, Mark J. Daly, Arthur J. Campbell, Dennis Lal. Comprehensive characterization of amino acid positions in protein structures reveals molecular effect of missense variants.
Proceedings of the National Academy of Sciences USA, Oct 2020, 202002660. PMID: 33106425. DIO: 10.1073/pnas.2002660117
Kimberly Goodspeed, Eduardo Pérez-Palma, Sumaiya Iqbal, Dominique Cooper, Annalisa Scimemi, Katrine M Johannesen, Arthur Stefanski, Scott Demarest, Katherine L Helbig, Jingqiong Kang, Frances C Shaffo, Brandon Prentice, Catherine A Brownstein, Byungchan Lim, Ingo Helbig, Emily De Los Reyes, Dianalee McKnight, Vincenzo Crunelli, Arthur J Campbell, Rikke S Møller, Amber Freed, Dennis Lal.
Current knowledge of SLC6A1-related neurodevelopmental disorders.
Brain Communications, fcaa170, 2020. DIO: https://doi.org/10.1093/braincomms/fcaa170.
Henrike O. Heyne, David Baez-Nieto, Sumaiya Iqbal, Duncan Palmer, Andreas Brunklaus, the Epi25 Collaborative, Katrine M. Johannesen, Stephan Lauxmann, Johannes R. Lemke, Rikke S. Møller, Eduardo Pérez-Palma, Ute Scholl, Steffen Syrbe, Holger Lerche, Patrick May, Dennis Lal, Arthur J. Campbell, Jen Pan, Hao-Ran Wang, Mark J. Daly.
Predicting Functional Effects of Missense Variants in Voltage-Gated Sodium and Calcium Channels.
Science Translational Medicine, 12(556), 2020. PMID: 32801145. DIO: 10.1126/scitranslmed.aay6848.
Sumaiya Iqbal, David Hoksza, Eduardo Pérez-Palma, Patrick May, Jakob B Jespersen, Shehab S Ahmed, Zaara T Rifat, Henrike O Heyne, M Sohel Rahman, Jeffrey R Cottrell, Florence F Wagner, Mark J Daly, Arthur J Campbell, Dennis Lal.
MISCAST: MIssense variant to protein StruCture Analysis web SuiTe.
Nucleic Acids Research, gkaa361, 2020. PMID: 32402084. DIO: https://doi.org/10.1093/nar/gkaa361.
Eduardo Pérez-Palma, Patrick May, Sumaiya Iqbal, Lisa-Marie Niestroj, Juanjiangmeng Du, Henrike O Heyne, Jessica A Castrillon, Anne O'Donnell-Luria, Peter Nürnberg, Aarno Palotie, Mark Daly, Dennis Lal.
Identification of pathogenic variant enriched regions across genes and gene families.
Genome Research, 30(1), 62-71, 2020. PMID: 31871067, DOI: 10.1101/gr.252601.119.
Andreas Brunklaus, Costin Leu, Marie Gramm, Eduardo Pérez-Palma, Sumaiya Iqbal, Dennis Lal.
Time to move beyond genetics towards biomedical data-driven translational genomic research in severe pediatric epilepsies.
European Journal of Paediatric Neurology, 24, 35-39, 2020. PMID: 31924506, DOI: 10.1016/j.ejpn.2019.12.001.
Zaara Rifat, Shehab Ahmed, Arthur J. Campbell, A. Keith Dunker, Sohel Rahman, Sumaiya Iqbal.
Map of Genetically Constrained Regions in Human Intrinsically Disordered Proteins.
Biophysical Journal (Abstract Issue), 118 (3), Supp. 1, 537A, 2020. DOI: https://doi.org/10.1016/j.bpj.2019.11.2942.
Shehab Ahmed, Zaara Rifat, Arthur J. Campbell, A. Keith Dunker, Sohel Rahman, Sumaiya Iqbal.
Burden of Functional Features and Genetic Variations in Human Intrinsically Disordered Proteins.
Biophysical Journal (Abstract Issue, Selected for platform talk), 118 (3), Supp. 1, 5A, 2020. DOI: https://doi.org/10.1016/j.bpj.2019.11.220.
S. Iqbal, E. Perez-Palma, J. Jespersen, P. May, D. Hoksza, H. Heyne, S. Ahmed, Z. Rifat, S. Rahman, K. Lage, A. Palotie, J. Cottrell, F. Wagner, M. Daly, A. Campbell, D. Lal.
Protein function-specific structural insights into the effect of Mendelian disease variants in 1,330 human genes.
American Society of Human Genetics Annual Meeting (Abstract, Selected for platform talk), Oct, 2019.
Tobias Brünger, Sumaiya Iqbal, Eduardo Perez-Palma, Mark J. Daly, Arthur J. Campbell, Patrick May, Dennis Lal. Identification of functionally essential sites using 3D single protein and multiprotein complexes across 73 neurodevelopmental disorder-associated genes.
American Society of Human Genetics Annual Meeting (Abstract, Selected for platform talk), Oct, 2019.
Chris Balak, Marianne Benard, Elise Schaefer, Sumaiya Iqbal, Keri Ramsey, Michèle Ernoult-Lange, Francesca Mattioli, Lorida Llaci, Véronique Geoffroy, Maité Courel, Marcus Naymik, Kristine K. Bachman, Rolph Pfundt, Patrick Rump, Johanna ter Beest, Ingrid M. Wentzensen, Kristin G. Monaghan, Kirsty McWalter, Ryan Richholt, Antony Le Béchec, Wayne Jepsen, Matt De Both, Newell Belnap, Anne Boland, Ignazio S. Piras, Jean-François Deleuze, Szabolcs Szelinger, Hélène Dollfus, Jamel Chelly, Jean Muller, Arthur Campbell, Dennis Lal, Sampathkumar Rangasamy, Jean-Louis Mandel, Vinodh Narayanan, Matt Huentelman, Dominique Weil, Amélie Piton.
Rare De Novo Missense Variants in RNA Helicase DDX6 Cause Intellectual Disability and Dysmorphic Features and Lead to P-Body Defects and RNA Dysregulation.
American Journal of Human Genetics, S0002-9297(19)30273-a, Aug 05, 2019. PMID: 31422817. DOI: https://doi.org/10.1016/j.ajhg.2019.07.010.
Juanjiangmeng Du, Monica Sudarsanam, Eduardo Pérez-Palma, Andrea Ganna, Laurent Francioli, Sumaiya Iqbal, Lisa-Marie Niestroj, Costin Leu, Ben Weisburd, Tim Poterba, Peter Nürnberg, Mark J Daly, Aarno Palotie, Patrick May, Dennis Lal.
Variant Score Ranker—a web application for intuitive missense variant prioritization.
Bioinformatics, 35 (21), 4478–4479, 2019. PMID: 31086968. DOI: https://doi.org/10.1093/bioinformatics/btz252.
Sumaiya Iqbal, Jakob Berg Jespersen, Eduardo Perez-Palma, Patrick May, Kasper Lage, Aarno Palotie, Florence F. Wagner, Jeffrey R. Cottrell, Mark Daly, Arthur J Campbell, Dennis Lal.
Functional Interpretation of Single Amino Acid Substitutions in 1,330 Disease-associated Genes.
Biophysical Journal (Abstract Issue), 116 (3), 420a-421a, 2019. DOI: 10.1016/j.bpj.2018.11.2266.
Heather E. Olson, Scott T. Demarest, Elia M. Pestana-Knight, Lindsay C. Swanson, Sumaiya Iqbal, Dennis Lal, Helen Leonard, J. Helen Cross, Orrin Devinsky, Tim A. Benke.
Cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder: clinical review.
Pediatric Neurology (accepted), 2019. PMID: 30928302. DOI: 10.1016/j.pediatrneurol.2019.02.015.
Sumaiya Iqbal, Md Tamjidul Hoque. PBRpredict-Suite: A Suite of Models to Predict Peptide Recognition Domain Residues from Protein Sequence. Bioinformatics, 11(9), e0161452, 2018. PMID: 29726965. DOI: 10.1093/bioinformatics/bty352.
Sumaiya Iqbal, Eduardo Perez-Palma, Jakob Berg Jespersen, Patrick May, Henrike Heyne, Kasper Lage, Florence F. Wagner, Mark Daly, Arthur J Campbell, Dennis Lal. Interpretation of Functional Consequences of Genetic Variants in Epilepsies using Protein Structures. American Epilepsy Society (Abstract), Nov, 2018.
Sumaiya Iqbal, Eduardo Perez-Palma, Jakob Berg Jespersen, Patrick May, Henrike Heyne, Kasper Lage, Florence F. Wagner, Mark Daly, Arthur J Campbell, Dennis Lal. Identification of Protein Features Associated with Mendelian Disease Variants. American Society of Human Genetics Annual Meeting (Abstract), Oct, 2018.
H.O. Heyne; S. Iqbal; T. Singh; E. Perez ; D. Palmer; H.-R. Wang; N. Whiffin; K. Johannesen; R. Møller; M.K. Veerapen; A. Palotie; F. Wagner; P. May; A.J. Campbell; D. Lal; M.J. Daly. Predicting pathogenicity and functional effects of missense variants in voltage-gated sodium and calcium channels. American Society of Human Genetics Annual Meeting, 2018.
A. Rochtus; S. Iqbal; E. Pérez-Palma; L. Smith; D. Lal; A. Poduri. Disease-associated sites in PCDH19 cluster in between cadherin domains depleted from the general population. American Society of Human Genetics Annual Meeting, 2018.
E. Pérez-Palma; P. May; S. Iqbal; H. Heyne; P. Nürnberg; A. Palotie; M. Daly; D. Lal. Exploring disease-associated regions across genes and gene families at mbv.broadinstitute.org. American Society of Human Genetics Annual Meeting, 2018.
Sumit Tarafder, Md. Toukir Ahmed, Sumaiya Iqbal, Md Tamjidul Hoque, M. Sohel Rahman. RBSURFpred: Modeling Protein Accessible Surface Area in Real and Binary Space using Regularized and Optimized Regression. Journal of Theoretical Biology, 2018, 441, 44 - 57. PMID: 29305182. DOI: 10.1016/j.jtbi.2017.12.029.
Sumaiya Iqbal, Jakob Berg Jespersen, Eduardo Perez-Palma, Patrick May, Henrike Heyne, Kasper Lage, Rikke Steensbjerre Moller, Florence F. Wagner, Mark Daly, Arthur J Campbell, Dennis Lal. Identification and Characterization of Variant Intolerant Sites Across Human Protein 3-dimensional Structures. Biophysical Journal (Abstract Issue), 114 (3), 664a, Feb, 2018. DOI: 10.1016/j.bpj.2017.11.3583.
Samin Rastgoufard, Sumaiya Iqbal, Md Tamjidul Hoque, Dimitrios Charalampidis. Genetic Algorithm Variant based Effective Solutions for Economic Dispatch Problems. IEEE Texas Power and Energy Conference, 2018. DOI: 10.1109/TPEC.2018.8312096
Denson Smith, Sumanth Yenduri, Sumaiya Iqbal, P. Venkata Krishna. An Efficient Distributed Protein Disorder Prediction using Pasted Samples. Computers & Electrical Engineering, 65, 342 - 356, 2017. DOI: 10.1016/j.compeleceng.2017.08.002
Sumaiya Iqbal, Md Tamjidul Hoque. A Study of Disorder-to-Order Transition by Characterizing the Binding Partners using a Statistical Potential. Biophysical Journal (Abstract Issue), 112(3), 209a, Feb 2017. DIO: 10.1016/j.bpj.2016.11.1153.
Sumaiya Iqbal, Md Tamjidul Hoque. hGRGA: A Scalable Genetic Algorithm using Homologous Gene Schema Replacement. Swarm and Evolutionary Computation, 2017, 34, 33 - 49. DOI: 10.1016/j.swevo.2016.12.001.
Md Tamjidul Hoque, Sumaiya Iqbal. Genetic Algorithm based Improved Sampling for Protein Structure Prediction. International Journal of Bio-Inspired Computation, 2017, 9(3), 129 - 141. DOI: 10.1504/IJBIC.2017.083702
Sumaiya Iqbal, Md Tamjidul Hoque. Prediction of Peptide-Binding Residues of Receptor Proteins in a Complex. The 5th Annual Conference on Computational Biology and Bioinformatics, Abstract, April 2017.
Sumaiya Iqbal, Md Tamjidul Hoque. Estimation of Position Specific Energy as a Feature of Protein Residues from Sequence alone for Structural Classification. PloS One, 11(9), e0161452, 2016. PMID: 27588752. DOI: 10.1371/journal.pone.0161452. GitHub: PSEE (https://github.com/iqbals/Position_Specific_Estimated_Energy), DisPredict2(https://github.com/tamjidul/DisPredict2_PSEE)
Avdesh Mishra, Sumaiya Iqbal and Md Tamjidul Hoque. Discriminate Protein Decoys from Native by using a Scoring Function based on Ubiquitous Phi and Psi Angles Computed for All Atom. Journal of Theoretical Biology, 2016, 398, 112 - 121. PMID: 27029514. DOI: 10.1016/j.jtbi.2016.03.029.
Mahmood A. Rashid, Sumaiya Iqbal, Firas Khatib, Md Tamjidul Hoque and Abdul Sattar. Guided Macro-mutation in a Graded Energy based Genetic Algorithm for Protein Structure Prediction. Computational Biology & Chemistry, 2016, 61, 162 - 177. PMID: 26878130. DOI: 10.1016/j.compbiolchem.2016.01.008.
Avdesh Mishra, Sumaiya Iqbal and Md Tamjidul Hoque. Evolutionary Approach to Template Free Ab-Initio Protein Structure Prediction Guided by Statistical Energy Function. Critical Assessment of Techniques for Protein Structure Prediction (CASP12), (Abstract), 2016, pp. 180 - 182.
Sumaiya Iqbal, Md Tamjidul Hoque. A Homologous Gene Replacement based Genetic Algorithm. Genetic and Evolutionary Computing Conference (Extended Abstract), March, 2016, pp. 91 - 92, Denver, CO, USA. DOI:10.1145/2908961.2909020.
Sumaiya Iqbal, Md Tamjidul Hoque. Estimation of Free Energy Contribution of Protein Residues as Feature for Structure Prediction from Sequence. The Great Lakes Bioinformatics and the Canadian Computational Biology Conference (GLBIO/CCBC), (Full paper), March, 2016, Toronto, ON, Canada.
Sumaiya Iqbal, Denson Smith, Md Tamjidul Hoque. Accurate Identification of Disordered Protein Residues using Deep Neural Network. The 4th Annual Conference on Computational Biology and Bioinformatics, Abstract, March 2016.
Denson Smith, Sumaiya Iqbal, and Md Tamjidul Hoque. A hybrid feature selection method for microarray data. The 4th Annual Conference on Computational Biology and Bioinformatics, Abstract, March 2016.
Avdesh Mishra, Sumaiya Iqbal and Md Tamjidul Hoque. An Eclectic Energy Function to Discriminate Native from Decoys. The 4th Annual Conference on Computational Biology and Bioinformatics, Abstract, March 2016.
Sumaiya Iqbal, Md Tamjidul Hoque. DisPredict: A Predictor of Disordered Protein using Optimized RBF Kernel. PloS One, 2015, 10(10), e141551. PMID: 26517719. DOI: 10.1371/journal.pone.0141551, GitHub: DisPredict (https://github.com/tamjidul/DisPredict_v1.0)
Md Nasrul Islam, Sumaiya Iqbal, Ataur R Katebi and Md Tamjidul Hoque. A Balanced Secondary Structure Predictor. Journal of Theoretical Biology, 2015, 389, 60 - 71. PMID: 26549467 DOI: 10.1016/j.jtbi.2015.10.015.
Sumaiya Iqbal, Avdesh Mishra, Md Tamjidul Hoque. Improved Prediction of Accessible Surface Area Results in Efficient Energy Function Application. Journal of Theoretical Biology, 2015, 380, 380 - 391. PMID: 26092374 DOI: 10.1016/j.jtbi.2015.06.012, Source: REGAd3p (http://cs.uno.edu/~tamjid/Software/REGAd3p/REGAd3p.tar.gz)
Sumaiya Iqbal, M Kaykobad, M Sohel Rahman. Solving the Multi-objective Vehicle Routing problem with Soft Time Windows with the Help of Bees. Swarm and Evolutionary Computation, 2015, 24(C), 50 - 64. DOI: 10.1016/j.swevo.2015.06.001.
Sumaiya Iqbal, Denson Smith, Avdesh Mishra, Md Nasrul Islam, Md Tamjidul Hoque. Disordered Protein Prediction by Spiders. Critical Assessment of Techniques for Protein Structure Prediction (CASP11), Abstract, 2014, pp. 215 - 216.
Shihabur Rahman Chowdhury, Md Mahbubul Hasan, Sumaiya Iqbal, M Sohel Rahman. Computing a Longest Common Palindromic Subsequence. Fundamenta Informaticae, 2014, 129(4), 329 - 340, IOS Press. DOI: 10.3233/FI-2014-974.
Sumaiya Iqbal, Md Nasrul Islam, Md Tamjidul Hoque. Improved Protein Disorder Predictor by Smoothing Output. [pdf]. International Conference on Computer & Information Technology (ICCIT), pages 110 - 115, IEEE, 2014. DOI: 10.1109/ICCITechn.2014.7073113.
Sumaiya Iqbal, M Sohel Rahman. Vehicle Routing Problems With Soft Time Windows. In Proceedings of 7th International Conference on Electrical & Computer Engineering (ICECE), 2012, 634 - 638, IEEE. DOI: 10.1109/ICECE.2012.6471630
Shihabur Rahman Chowdhury, Md Mahbubul Hasan, Sumaiya Iqbal, M Sohel Rahman. Computing a Longest Common Palindromic Subsequence. Combinatorial Algorithms (Proceedings of 23rd International Workshop IWOCA), 2012, 7643, pp 219-223, Springer Berlin Heidelberg. DOI: 10.1007/978-3-642-35926-2_24
Sumaiya Iqbal, Shihabur Rahman Chowdhury, Chowdhury Sayeed Hyder, Athanasios V Vasilakos, Cheng-Xiang Wang.Vehicular communication: protocol design, testbed implementation and performance analysis. In Proceedings of the 2009 International Conference on Wireless Communications and Mobile Computing: Connecting the World Wirelessly, 410 - 415, ACM, 2009. DOI: http://dl.acm.org/citation.cfm?id=1582469.
Machine Learning based Protein Sequence to (un)Structure Mapping and Interaction Prediction, PhD Dissertation, August, 2017. [link]
Accurate prediction of disordered protein from sequence alone, PhD Dissertation Proposal, 05 May, 2016.[proposal] [presentation]
Vehicle Routing Problems with Soft Time Windows. M.Sc. Thesis, 2012. [link]
Algorithms in Bioinformatics. B.Sc. Thesis, 2009. [link]