1. Woo JN, Kim JE, Suh BC (2026) Structural rigidity of the I-II loop couples CaV β anchoring to CaV2.2 gating modes. Proc. Natl. Acad. Sci. USA 123, e2602744123.
2. Kim JE, Lee BC, Suh BC (2026) TMEM16E-mediated macropinocytosis promotes cell survival under acidic stress. Cell. Mol. Life Sci. In press
3. Yang SY, Yun T, Lee Y, Jeon JH, Kim S, Lim EY, Park J, Kim YG, Jung J, Woo JN, Zhang Y, Son H, Shannonhouse J, Kim J, Cho E, Sung YH, Hwang EM, Suh BC, Park P, Song MR, Baek M, Lee J, Kim YS, Park JY, Lee H (2026) TWIK-1 contributes to mechanical sensation in naïve and neuropathic conditions. Signal Transduct. Target. Ther. 11, 248.
4. Tian Y, Bae S, Wu X, Rouen KC, Gonzalez AH, Han Y, Tekreeti AA, Vu S, Vorobyov I, Yaro-Yarovoy V, Suh BC, Hwang S, Zheng J (2026) Heat- and PIP2-dependent TRPM4 activity underlies mutually exclusive human diseases. Proc. Natl. Acad. Sci. USA 123, e2530328123.
5. Jeong DJ, Woo JN, Yun T, Baek M, Suh BC (2025) Kv7 channels as an important contributor to alcohol-induced modulation of neuronal excitability in neonatal rat superior cervical ganglion. Cells 14(21), 1723. doi: 10.3390/cells14211723.
6. Kim BI, Yeon JH, Suh BC (2025) Palmitoylation Code and Endosomal Sorting Regulate ABHD17A Plasma Membrane Targeting and Activity. Int. J. Mol. Sci. 26(20), 10190. doi: 10.3390/ijms262010190.
7. Kim JE, Ko W, Jin S, Woo JN, Jung Y, Bae I, Choe HK, Seo D, Hille B, Suh BC (2025) Activation of TMEM16E scramblase induces ligand-independent growth factor receptor signaling and macropinocytosis for membrane repair. Commun. Biol. 8, 35. doi: 10.1038/s42003-025-07465-6.
8. Kim DY†, Moon KM†, Heo W†, Du EJ, Park CG, Cho J, Hahm JH, Suh BC, Kang KJ*, Kim K* (2024) A FMRFamide-like neuropeptide FLP-12 signaling regulates foraging-like behaviors in C. elegans. BMB Reports 47, 100124. doi: 10.1016/j.mocell.2024.100124.
9. Ko W, Lee E, Kim JE, Lim HH, Suh BC (2024) The plasma membrane inner leaflet PI(4,5)P2 is essential for the activation of proton-activated chloride channels. Nat. Commun. (2024) 15, 7008.
10. Wayesssa RA#, Woo JN#, Kim SY#, Choi H#, Sung HY, Choi MS, Choi M, Yoon SE, Kim YJ, Suh BC*, Kang KJ*, Kwon JY* (2024) Molecular and cellular basis of sodium sensing in Drosophila labellum. iScience 27, 110248.
11. Lee H, Cho S, Kim MJ, Park YJ, Cho E, Jo YS, Kim YS, Lee JY, Thoudam T, Woo SH, Lee SI, Jeon J, Lee YS, Suh BC, Yoon JH, Go Y*, Lee IK*, Seo J* (2023) ApoE4-dependent lysosomal cholesterol accumulation impairs mitochondrial homeostasis and oxidative phosphorylation in human astrocytes. Cell Rep. 42, 113183.
12. Kim YS, Yeon JH, Ko W, and Suh BC (2023) Two-step structural change of M3 receptor activation relies on the coupled Gq protein cycle. Nat. Commun. 14, 1276.
13. Kim YE*, Kim YS*, Lee HE, So KH, Choe Y, Suh BC, Kim JH, Park SK, Mathern GW, Gleeson JG, Rah JC**, and Baek ST** (2023) Reversibility and developmental neuropathology of linear nevus sebaceous syndrome caused by dysregulation of the RAS-MAPK pathway. Cell Rep. 42, 112003.
14. Jeong DJ, Kim KW, and Suh BC (2023) Dual regulation of Kv7.2/7.3 channels by long-chain n-alcohols. J. Gen. Physiol. 154, e202113074.
15. Kim Y* and Suh BC* (2022) Editorial: Brain Cells’ Compensatory Mechanisms in Response to Disease Risk Factors. Front. Mol. Neurosci. 15, 1096287. *co-correspondence.
16. Park CG, Yu W, and Suh BC (2022) Molecular basis of the PIP2-dependent regulation of the CaV2.2 voltage-gated Ca2+ channel and its modulation by CaV β subunits. eLife 11, e69500.
17. Moon S, Kim YJ, Park HE, Kim J, Gho YS, Hong WJ, Kim EJ, Lee SK, Suh BC, An G, and Jung KH (2022) GTD5/OsSNDP3 functions for the polar tip growth in rice pollen together with OsSNDP2, a paralog of GTD5/OsSNDP3. Rice 15, 39.
18. Jensen JB, Falkenburger B, Dickson E, de la Cruz L, Dai G, Myeong J, Jung SR, Kruse M, Vivas O, Suh BC, and Hille B (2022) Biophysical physiology of phosphoinositide rapid dynamics and regulation in living cells. J. Gen. Physiol. 154, e202113074.
19. Kim KW#, Kim K#,*, Kim HJ, Baek M, and Suh BC* (2021) Post-transcriptional modulation of KCNQ2 gene expression by the miR-106b microRNA family. Proc. Natl. Acad. Sci. USA 118, e2110200118. #co-first, *co-correspondence.
20. Moon KM, Kim J, Seong Y, Suh BC, Kang KJ, Choe HK, and Kim K (2021) Proprioception, the regulator of motor function. BMB Reports 54, 393-402.
21. Kim KW and Suh BC (2021) Regulation of Kv7.2/7.3 channel open probability and PI(4,5)P2 affinity by ethanol. BMB Reports 54, 311-316.
22. Ko W and Suh BC (2021) Differential regulation of Ca2+-activated Cl- channel TMEM16A splice variants by membrane PI(4,5)P2. Int. J. Mol. Sci. 22, 4088.
23. Myeong J, Park CG, Suh BC, and Hille B (2021) Compartmentalization of phosphatidylinositol 4,5-bisphosphate metabolism into plasma membrane liquid-ordered/raft domains. Proc. Natl. Acad. Sci. USA 118, e2025343118. F1000 Biology
24. Ko W*, Jung SR*, Kim KW, Yeon JH, Park CG, Nam JH, Hille B, and Suh BC (2020) Allosteric modulation of alternatively spliced Ca2+-activated Cl- channels TMEM16A by PI(4,5)P2 and CaMKII. Proc. Natl. Acad. Sci. USA 117, 30787-30798.
25. Myeong J, de la Cruz L, Jung SR, Yeon JH, Suh BC, Koh DS, and Hille B (2020) Phosphatidylinositol 4,5-bisphosphate is regenerated by speeding of the PI 4-kinase pathway during long PLC activation. J. Gen. Physiol. 152, e202012627.
26. Kim KW, Kim K, Lee H*, and Suh BC* (2019) Ethanol elevates excitability of superior cervical ganglion neurons by inhibiting Kv7 channels in a cell type-specific and PI(4,5)P2-dependent manner. Int. J. Mol. Sci. 20, E4419.
27. Lee JS, Kweon HJ, Lee H*, and Suh BC* (2019) Rapid resensitization of ASIC2a is conferred by three amino acid residues in the N-terminus. J. Gen. Physiol. 151, 944-953. *co-correspondence.
28. Yeon JH, Park CG, Hille B*, and Suh BC* (2018) Translocatable voltage-gated Ca2+ channel β subunits in α1-β complexes reveal competitive replacement yet no spontaneous dissociation. Proc. Natl. Acad. Sci. USA 115, E9934-E9943 *co-correspondence.
29. Park CG and Suh BC (2018) Modulation mechanisms of voltage-gated calcium channels. Curr. Opin. Physiol. 2, 77-83.
30. Park CG and Suh BC (2017) The HOOK region of β subunits controls gating of voltage-gated Ca2+ channels by electrostatically interacting with plasma membrane. Channels (Austin) 5, 467-475.
31. Park CC, Park Y, and Suh BC (2017) The HOOK region of voltage-gated Ca2+ channel β subunits senses and transmits PIP2 signals to the gate. J. Gen. Physiol. 149, 261-276.
32. Kweon HJ, Cho JH, Jang IS, and Suh BC (2016) ASIC2a-dependent increase of ASIC3 surface expression enhances the sustained component of the currents. BMB Reports 49, 542-547.
33. Kweon HJ, Kim DI, Bae Y, Park JY, and Suh BC (2016) Acid-Sensing Ion Channel 2a (ASIC2a) promotes surface trafficking of ASIC2b via heteromeric assembly. Scientific Reports 6, 30684.
34. Suh BC*, Yeon JH, and Park CG (2016) PI(4,5)P2 and L-type Ca2+ channels partner up to fine-tune Ca2+ dynamics in β cells. Chemistry & Biology (Cell Chem. Biol.) 23, 753-755. Preview *correspondence
35. Kim DI, Kweon HJ, Park Y, Jang DJ, and Suh BC (2016) Ca2+ controls gating of voltage-gated calcium channels by releasing the β2e subunit from the plasma membrane. Science Signaling 9, ra67.
36. Keum D#, Kruse M#, Kim DI, Hille B*, and Suh BC* (2016) Phosphoinositide 5- and 3-phosphatase activities of a voltage-sensing phosphatase in living cells show identical voltage dependence. Proc. Natl. Acad. Sci. USA 113, E3686-E3695. #co-first, *co-correspondence.
^ Commentary in Proc. Natl. Acad. Sci. USA (2016) 113:7012-4
37. Jeong JY, Kweon HJ, and Suh BC (2016) Dual regulation of R-type CaV2.3 channels by M1 muscarinic receptors. Mol. Cells 39, 322-329. F1000 Biology
38. Kim DI and Suh BC (2016) Differential interaction of β2e with phospholipids: a comparative study between β2e and MARCKS. Channels (Austin) 10, 238-246.
39. Kim DI, Kang M, Kim S, Lee J, Park Y, Chang I*, and Suh BC* (2015) Molecular basis for dynamic membrane-interaction of β subunit of voltage-gated Ca2+ channels. Biophys. J. 109, 922-935. *co-correspondence
40. Moon H, Kim MJ, Son HJ, Kweon HJ, Kim JT, Kim Y, Shim J, Suh BC, and Rhyu MR (2015) Five hTRPA1 agonists found in indigenous Korean mint, Agastache rugose. PLoS One 10, e0127060.
41. Kim DI, Park Y, Jang DJ, and Suh BC (2015) Dynamic phospholipid interaction of β2e subunit regulates the gating of voltage-gated Ca2+ channels. J. Gen. Physiol. 145, 529-541.
42. Kweon HJ, Yu SY, Kim DI, and Suh BC (2015) Differential regulation of proton-sensitive ion channels by phospholipids: A comparative study between ASICs and TRPV1. PLoS One 10, e0122014.
43. Jun YW, Kim S, Kim KH, Lee JA, Lim CS, Chang I, Suh BC, Kaang BK, and Jang DJ (2015) Analysis of phosphoinositide-binding properties and subcellular localization of GFP-fusion proteins. Lipids 50, 427-436.
44. Hille B, Dickson EJ, Kruse M, Vivas O, and Suh BC (2015) Phosphoinositides regulate ion channels. Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1851, 844-856.
45. Keum D and Suh BC (2015) Molecular basis for N-type voltage-gated Ca2+ channel modulation by Gq protein-coupled receptors. Receptors Clin. Investig. 2, e515.
46. Keum D, Baek D, Kim DI, Kweon HJ, and Suh BC (2014) Voltage-dependent regulation of CaV2.2 channels by Gq-coupled receptor is facilitated by membrane localized β subunit. J. Gen. Physiol. 144, 297-309.
47. Kim KH, Jun YW, Park Y, Lee JA, Suh BC, Lim CS, Lee YS, Kaang BK, and Jang DJ (2014) Intracellular membrane association of Aplysia cAMP phosphodiesterase long- and short-form via different targeting mechanisms. J. Biol. Chem. 289, 25797-25811.
48. Kim MJ, Son HJ, Kim Y, Kweon HJ, Suh BC, Lyall V, and Rhyu MR (2014) Selective activation of hTRPV1 by N-geranyl cyclopropylcarboxamide, an amiloride-insensitive salt taste enhancer. PLoS One 9, e89062.
49. Kweon HJ and Suh BC (2013) Acid-sensing ion channels (ASICs): a therapeutic target for neurological diseases and its regulation. BMB Reports 46, 295-304.
50. Suh BC*, Dong-Il Kim, Falkenburger BH, and Hille B (2012) Membrane-localized β-subunits alter the PIP2 regulation of high-voltage activated Ca2+ channels. Proc. Natl. Acad. Sci. USA 109, 3161-3166. *Corresponding author. F1000 Biology
51. Suh BC*, Leal K, and Hille B (2010) Modulation of high-voltage activated Ca2+ channels by membrane phosphatidylinositol 4,5-bisphosphate. Neuron 67, 224-238. * Corresponding author. F1000 Biology.
52. Falkenburger BH, Jensen JB, Dickson EJ, Suh BC, and Hille B (2010) Phosphoinositides: lipid regulators of membrane proteins. J. Physiol. 588, 3179-3185. Symposium report
53. Chun SY, Shin S, Kim Y, Cho H, Park MK, Kim TW, Voronov SV, Di Paolo G, Suh BC, and Chung S (2010) Cholesterol modulates ion channels via downregulation of phosphatidylinositol 4,5-bisphosphate. J. Neurochem. 112, 1286-1294.
54. Suh BC and Hille B (2008) PIP2 is a necessary cofactor for ion channel function: How and why? Annu. Rev. Biophys. Biomol. Struct. 37, 175-195. Review
55. Suh BC and Hille B (2007) Electrostatic interaction of internal Mg2+ with membrane PIP2 seen with KCNQ K+ channels. J. Gen. Physiol. 130, 241-256. F1000 Biology
^Cover picture in J. Gen. Physiol. (2007) Sep 130(3)
56. Suh BC and Hille B (2007) Regulation of KCNQ channels by manipulation of phosphoinositides. J. Physiol. 43, 911-916. Symposium report
57. Suh BC*, Inoue T*, Meyer T, and Hille B (2006) Rapid chemically-induced changes of PtdIns(4,5)P2 gate KCNQ ion channels. Science 314, 1454-1457. *Contributed equally.
^Comment in Science (2006) 314:1402-3
^Spotlight in ACS Chem. Biol. (2006) 1:608
58. Suh BC and Hille B (2006) Does diacylglycerol regulate KCNQ channels? Pflugers Arch. 453, 293-301.
59. Horowitz LF*, Hirdes W*, Suh BC*, Hilgemann D, Mackie K, and Hille B (2005) Phospholipase C in living cells: Activation, inhibition, Ca2+ requirement, and regulation of M-current. J. Gen. Physiol. 126, 243-262. *Contributed equally. F1000 Biology
60. Suh BC and Hille B (2005) Regulation of ion channels by phosphatidylinositol 4,5-bisphosphate. Curr. Opin. Neurobiol. 15, 370-378. Review
61. Lee H, Jun DJ, Suh BC, Choi BH, Lee JH, Do MS, Suh BS, Ha H, and Kim KT (2005) Dual roles of P2 purinergic receptors in insulin-stimulated leptin production and lipolysis in differentiated rat white adipocytes. J. Biol. Chem. 280, 28556-28563.
62. Suh BC, Horowitz LF, Hirdes W, Mackie K, and Hille B (2004) Regulation of KCNQ2/KCNQ3 current by G protein cycling: the kinetics of receptor-mediated signaling by Gq. J. Gen. Physiol. 123, 663-683.
^Comment in J. Gen. Physiol. (2004) 123:657-62
^Highlight in Physiology (2004) 19:161
63. Namgung UK, Choi BH, Park SH, Lee JU, Seo HS, Suh BC, and Kim KT (2004) Activation of cyclin-dependent kinase 5 is involved in axonal regeneration. Mol. Cell. Neurosci. 25, 422-432.
64. Lee H, Choi BH, Suh BC, Lee SK, and Kim KT (2003) Attenuation of signal flow from P2Y6 receptor by protein kinase C-α in SK-N-BE(2)C human neuroblastoma cells. J. Neurochem. 85, 1043-1053.
65. Lee IS, Hur EM, Suh BC, Kim MH, Koh DS, Rhee IJ, Ha H, and Kim KT (2003) Protein kinase A- and C-induced insulin release from Ca2+-insensitive pools. Cell Signal. 15, 529-537.
66. Suh BC and Hille B (2002) Recovery from muscarinic modulation of M-current channels requires phosphatidylinositol 4,5-bisphosphate synthesis. Neuron 35, 507-520. F1000 Biology
^Comment in Neuron (2002) 35:411-2
^Highlight in Nat. Rev. Neurosci. (2002) 3:676
67. Suh BC, Lee H, Chun DJ, Chun JS, Namgung U, and Kim KT (2001) Inhibition of H2 histamine receptor-mediated cation channel opening by protein kinase C in HL-60 promyelocytic leukemia cells. J. Immunol. 167, 1663-1771.
68. Suh BC, Han S, and Kim KT (2001) Selective inhibition of β2-adrenergic receptor-mediated cAMP generation by the activation of P2Y2 receptor in mouse pineal tumor cells. J. Neurochem. 77, 1475-1485.
69. Suh BC, Lee H, and Kim KT (2001) Inhibition of histamine-induced [Ca2+]i rise and cAMP production by extracellular nucleotides in HL-60 promyelocytic leukemia cells. J. Leukoc. Biol. 69, 169-176.
70. Suh BC, Kim JS, Kim TD, and Kim KT (2001) Pharmacological characterization of adenosine receptors in PGT-β mouse pineal gland tumor cells. Br. J. Pharmacol. 134, 132-142.
71. Yi KS, Chung JH, Lee YH, Chung HG, Kim IJ, Suh BC, Kim E, Cocco L, Ryu SH, and Suh PG (2001) Inhibition of the EGF-induced activation of phospholipase C-γ1 by a single chain antibody fragment. Oncogene 20, 7954-7964.
72. Choi SY, Choi BH, Suh BC, Chae HD, Kim JS, Shin MJ, Kang SS, Negishi M, and Kim KT (2001) Potentiation of PGE2-mediated cAMP production during neuronal differentiation of human neuroblastoma SK-N-BE(2)C cells. J. Neurochem. 79, 303-310.
73. Suh BC, Kim JS, Namgung U, Ha H, and Kim KT (2001) P2X7 nucleotide receptor mediation of membrane pore formation and superoxide generation in human promyelocytes and neutrophils. J. Immunol. 166, 6754-6763.
74. Suh BC, Kim TD, Lee IS, and Kim KT (2000) Differential regulation of P2Y11 receptor-mediated signaling to phospholipase C and adenylyl cyclase by protein kinase C in HL-60 promyelocytes. Br. J. Pharmacol. 131, 489-497.
75. Suh BC, Kim MJ, Choi, G, Choi KY, Han JK, Chung SK, and Kim KT (2000) Differential stereoselectivity of D- and L-myo-inositol 1,2,4,5-tetrakisphosphate binding to the inositol 1,4,5-trisphosphate receptor and 3-kinase. Neurochem. Int. 37, 37-52.
76. Lee IS, Park TJ, Suh BC, Rhee IJ, Kim YS, and Kim KT (1999) Chlorpromazine-induced inhibition of catecholamine secretion by a differential blockade of nicotinic receptors and L-type Ca2+ channels in rat pheochromocytoma cells. Biochem. Pharmacol. 58, 1017-1024.
77. Suh BC, Chae HD, Chung JH, and Kim KT (1999) Pharmacological characterization of β2-adrenergic receptors in PGT-β mouse pineal gland tumor cells. Br. J. Pharmacol. 126, 399-406.
78. Chung SK, Shin BG, Chang YT, Suh BC, and Kim KT (1998) Syntheses of D- and L-myo-inositol 1,2,4,5-tetrakisphosphate and stereoselectivity of the Ins(1,4,5)P3 receptor binding. Bioorg. Med. Chem. Lett. 8, 659-662.
79. Suh BC, Lee IS, Chae HD, Han S, and Kim KT (1998) Characterization of Mas-7-induced pore formation in SK-N-BE(2)C human neuroblastoma cells. Mol. Cells 8, 162-168.
80. Suh BC, Choi SY, Chun JS, and Kim KT (1998) Opposing regulatory effects of protein kinase C on the cAMP cascade in human HL-60 promyelocytic leukemia cells. Eur. J. Pharmacol. 353, 105-115.
81. Park TJ, Shin SY, Suh BC, Suh EK, Kim YS, and Kim KT (1998) Differential inhibition of catecholamine secretion by amitriptyline through blockage of nicotinic receptors, sodium channels and calcium channels in bovine chromaffin cells. Synapse 68, 248-256.
82. Lee H, Suh BC, and Kim KT (1997) Feedback regulation of ATP-induced Ca2+ signaling in HL-60 cells is mediated by protein kinase A- and C-mediated changes in capacitative Ca2+ entry. J. Biol. Chem. 272, 21831-21838.
83. Suh BC, Son JH, Joh TH, and Kim KT (1997) Two distinct P2-purinergic receptors, P2Y and P2U, are coupled to phospholipase C in mouse pineal gland tumor cells. J. Neurochem. 68, 1622-1632.
84. Song SK, Suh BC, Lee H, and Kim KT (1997) Histamine inhibits ATP-induced [Ca2+]i rise through the activation of protein kinase A in HL-60 cells. Eur. J. Pharmacol. 322, 265-273.
85. Suh BC, Park TJ, and Kim KT (1996) Synergistic activation of adenylyl cyclase is dependent upon phospholipase C-mediated processes in SK-N-BE(2)C cells. Eur. J. Pharmacol. 314, 235-242.
86. Suh BC, Song SK, Kim YK, and Kim KT (1996) Induction of cytosolic Ca2+ elevation mediated by Mas-7-occurs through membrane pore formation. J. Biol. Chem. 271, 32753-32759.
87. Chae HD, Suh BC, Joh TH, and Kim KT (1996) AP-1 mediated transcriptional enhancement of the rat tyrosine hydroxylase gene by muscarinic stimulation. J. Neurochem. 66, 1264-1272.
88. Suh BC and Kim KT (1995) Identification of M3 muscarinic receptor which is coupled to phospholipase C and adenylyl cyclase in SK-N-BE(2)C cells. Mol. Cells 5, 86-92.
89. Suh BC, Lee CO, and Kim KT (1995) Signal flows from two phospholipase C-linked receptors are independent in PC12 cells. J. Neurochem. 64, 1071-1079.
90. Suh BC and Kim KT (1995) Stimulation of adenylyl cyclase mediated by phospholipase C-linked M3 muscarinic receptor in human neuroblastoma SK-N-BE(2)C cells. J. Neurochem. 64, 2500-2508.
91. Suh BC and Kim KT (1995) Inhibition of bradykinin-induced cytosolic Ca2+ elevation by muscarinic stimulation without attenuation of inositol 1,4,5-trisphosphate production in human neuroblastoma SK-N-BE(2)C cells. J. Neurochem. 65, 2124-2130.
92. Suh BC and Kim KT (1994) Inhibition by ethaverine of catecholamine secretion through blocking L-type Ca2+ channels in PC12 cells. Biochem. Pharmacol. 47, 1262-1266.