Research & Projects
Research & Projects
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An activatable magnetic resonance imaging contrast agent + drug delivery
An activatable magnetic resonance imaging contrast agent + drug delivery
With an iron oxide nanoparticle core synthesized via coprecipitation, then coated with stock poly(ethylene glycol) and a proprietary polymer synthesized in house called poly(gallol), we have the power to make an MRI contrast agent that will turn "on" in the presence of oxidative stress!
We're also working on the encapsulation of drug into these particles for a theranostic agent that can generate contrast while also delivering anti-inflammatory pharmaceuticals!
Iron oxide nanoparticle synthesis optimization project
Iron oxide nanoparticle synthesis optimization project
Coprecipitation is the most widely used chemical method of synthesizing iron oxide nanoparticles, which involves adding a precipitating agent to an iron chloride solution to initiate the reaction. But the dynamics of the reaction are complex, and a single change in a variable can have drastic implications on the outcome of your nanoparticle characteristics. We explored how the flow rate of ammonium hydroxide impacts the particle size, hydrodynamic size, colloidal stability, and polydispersity of iron oxide nanoparticles.
We were proud to publish our results in Colloids and Surfaces A: Physicochemical and Engineering Aspects!
View our paper here!
https://www.sciencedirect.com/science/article/abs/pii/S092777572401882X
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