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microRNAs (miRNAs) are short non-coding RNA species, which act as potent gene expression regulators. Accurate identification of miRNA targets is crucial to understanding their function. Currently, hundreds of thousands of miRNA:gene interactions have been experimentally identified. However, this wealth of information is fragmented and hidden in thousands of manuscripts and raw next-generation sequencing data sets. DIANA-TarBase was initially released in 2006 and it was the first database aiming to catalog published experimentally validated miRNA:gene interactions. DIANA-TarBase v7.0 ( ) aims to provide for the first time hundreds of thousands of high-quality manually curated experimentally validated miRNA:gene interactions, enhanced with detailed meta-data. DIANA-TarBase v7.0 enables users to easily identify positive or negative experimental results, the utilized experimental methodology, experimental conditions including cell/tissue type and treatment. The new interface provides also advanced information ranging from the binding site location, as identified experimentally as well as in silico, to the primer sequences used for cloning experiments. More than half a million miRNA:gene interactions have been curated from published experiments on 356 different cell types from 24 species, corresponding to 9- to 250-fold more entries than any other relevant database. DIANA-TarBase v7.0 is freely available.


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Mattermost v7.0 is generally available today and includes three of our top five most requested features, based directly on your input in our feature idea forum. The following new features are all included (see changelog for more details):

Thanks for all community contributions this month and, in particular, our v7.0 Most Valued Professional (MVP), Tom De Moor, who has contributed a lot to our localization community and has 39 lifetime code contributions. Thank you for your continued contributions, Tom!

New analyzers include one year of software maintenance, licensing that instrument for APx version 8.0 when it is released, as well as any minor releases that occur between versions 7.0 and 8.0. Release 7.0 is compatible with all analyzers in the APx500 Series, however an APx KeyBox is required to run v7.0 on Legacy APx analyzers.

Greater efficiency in PPDS v7.0 is accomplished through new Determinant Codes to broaden the scene description in relation to officer safety. The remaining Determinant Codes are renumbered and/or adjusted for clarification. The updated version also continues to highlight alternative call pathways that give EPDs the ability to route non-urgent or low-priority events to non-traditional responses or special referrals while in ProQA.

Protocol 123: Missing/Runaway/Found Person

PPDS v7.0 adds JAQs to determine if the missing child has been identified as within the autism spectrum and if there are any hazardous locations near where the child went missing (such as retention ponds). This set of questions conforms to a pilot training program for emergency telecommunicators by the Florida Department of Law Enforcement (FDLE) Missing Endangered Persons Information Clearinghouse (MEPIC).

Ed-Fi ODS / API v7.0 add support for implementing Ed-Fi Data Standard v5, which introduces important updates that impact multiple domains of the Ed-Fi data model. Refer to What's New - v5 for details. There are breaking changes to the model so implementers are advised to review the changes carefully.

In the past, each release of the Ed-Fi ODS / API implemented a specific version of the Data Standard. Ed-Fi ODS / API v7.0 introduces the capability to build and deploy APIs that adhere to either the Ed-Fi Data Standard v4 or Ed-Fi Data Standard v5. This enhancement involves updates to the source code structure, build process, packaging, and deployment components of the technology stack to process either one of the data standard versions. This flexibility empowers implementations to leverage bug fixes and advancements within the technology suite, while incorporating supported data standard upgrades at a pace suitable for their institution's needs.

It is important for implementers to note that Ed-Fi ODS / API v7.0 introduces breaking changes listed in the release notes. These changes will impact the behavior of the API in both Ed-Fi Data Standard v4 and Ed-Fi Data Standard v5 implementations. Additionally, Ed-Fi ODS / API v7.0 brings non-breaking changes to the ODS database schema, aimed at enhancing performance. Implementers are advised to upgrade their existing ODS to incorporate these schema changes, particularly when upgrading from an existing Ed-Fi Data Standard v4 (ODS / API v6.1) implementation. Beyond the ODS, it's essential to update the Admin and Security database schemas to the latest versions when upgrading to Ed-Fi ODS / API v7.0 for implementing Ed-Fi Data Standard v4.

Ed-Fi ODS / API profiles facilitate the creation of data policies for specific sets of API resources, thereby limiting the data (including properties, collections, and collection items) available for reading and writing. In the past releases, configuring profiles required code modifications, rebuilding and redeployment. Ed-Fi ODS / API v7.0 introduces the capability for runtime profile configuration and updates without the requirement for recompilation or redeployment. Additionally, profiles now integrate seamlessly with extension plugins. This enhancement empowers administrators to modify data policies even after the deployment of ODS / API throughout the school year, accommodating evolving consumer needs. For general overview of profiles feature refer to API Profiles and for for technical implementation details consult How To: Add Profiles to the Ed-Fi ODS / API.

In addition to profile configuration, Ed-Fi ODS / API v7.0 simplifies profile usage. The ODS / API now evaluates incoming API requests to determine whether the requested resource is linked to a single profile for the API client. If this is the case, API will automatically handles the request using that specific profile and API client is not obligated to to apply profile specific HTTP header to the request (i.e. Accept for GET requests, and Content-Type for PUT/POST requests).

Ed-Fi ODS / API v7.0 introduces architectural changes that enhance scalability, performance, and deployment flexibility beyond what was achievable in previous versions. ODS instances are now configured and linked to API clients within the Admin database, allowing configuration of complete connection strings. This setup enables ODS instances to reside on separate database servers, ensuring improved performance and security. Refer to API Client and ODS Instance Configuration for details. API administrators retain the ability to implement previously supported database segmentation strategies. API administrators can opt for implicit routes (segmentation information not visible in the routes). Additionally, administrators have the option to configure database segmentation for explicit routes with Context-Based Routing. Streamlined routes in ODS / API v7.0 offer simplified route configurations within client applications. Details on route patterns can be found in the API Routes section.

The newly redesigned SafeDispatch v7.0 is a professional client-hosted software application that enables two-way users to host and manage an intuitive radio system display, Voice Dispatch and AVL solution on their own computer without incurring any monthly fees associated with other web-based or cellular options.

SafeDispatch v7.0 provides all the necessary means to effectively track and monitor mobile assets and personnel by adding intelligent features that work in conjunction with the embedded capabilities of your DMR, TETRA and P-25 radios.

Adding SafeDispatch v7.0 solutions almost instantly provide a return on your investment through benefits including: increased productivity, time and route management, effective customer service, fleet maintenance monitoring, insurance premium reductions for incorporating GPS/AVL applications into your business model, improved communication, real-time data to pinpoint cost saving opportunities, reductions in overtime and other operating expenses and many more.

The enhanced capability of Voice over IP allows the dispatcher to communicate with their subscribers directly with Push-To-Talk capability for Private, Group and All Calls using the SafeDispatch v7.0 application interface on-screen and control stations. Voice Recording enables the recording and logging of all calls simultaneously through the Direct IP recording suite.

SafeDispatch v7.0 is enhanced with text messaging capability that allows for SMS communication between the radio(s) and the dispatcher. The dispatcher can send messages to any radio or group of radios and can also receive messages from radios in a dedicated user-friendly messaging screen.

The SafeDispatch v7.0 Reporting Module offers a variety of reports available for intuitive data interpretation to effectively monitor and improve productivity and performance: ARS, Speeding Report, End of Day Report, Stops Report, Fleet Report, Geofencing & Landmarking Report are just some of the many available.

Since then we have been working towards removing PhantomJS. In October 2019, when Grafana v6.4 was released, we announced the deprecation of PhantomJS. Grafana v7.0 removes all PhantomJS support which means that Grafana distribution no longer will include a built-in image renderer. e24fc04721

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