List of Publications

Bioresponsive MR Imaging Probes for Noninvasive Monitoring of AAV Gene Therapy
Srinivasan Jayakumar Jian-HongTang, Toloo Taghian, Giacomo Parigi, Claudio Luchinat, Erin Hall, Heather L. Gray-Edwards, Thomas J. Meade.
Bioconjugate Chemistry: https://doi.org/10.1021/acs.bioconjchem.5c00525

Identification of Non-Competitive and Reversible Inhibitors of Glycine Transporter 2: A Promising Non-Opioid Therapeutic Strategy for Neuropathic Pain
Christopher Cioffi, Tanmay Pati, Irina Lotsaris, Srinivasan Jayakumar, Julian Peiser-Oliver, Gaddam Mahesh, Ryan Cantwell Chater, Aravindan Jayaraman, Zachary Frangos, Krishna Suleria, Sally Evans, Ramajayam Kuppusamy, Arun Raja, Parthasarathy Muthuraman, Jay Mulmule, Suman Mishra, Snigdha Singh, Arunan Palanimuthu, Michael Michaelides, Azadeh Shahsavar, Sarasa Mohammadi, Robert Vandenberg.

Synthesis, Photophysical Characterization, and Bioimaging with Benzoquinolizine-Based Fluorescent Dyes Prepared through an Aryne-Induced Domino Reaction
Srinivasan Jayakumar, Avijit Panja, Nitesh K. Gupta, Wen-Chieh Huang, Kuo Chu Hwang, Munusamy Shanmugam, Yu-Chen Hu, Fa-Kuen Shieh, Shwu-Chen Tsay, Jih Ru Hwu
Chemphotochem.  https://doi.org/10.1002/cptc.202500212

The efficacy of the analgesic GlyT2 inhibitor, ORG25543, is determined by two connected allosteric sites
Cantwell Chater, Ryan; Quinn, Ada; Wilson, Katie; Frangos, Zachary; Sutton, Patrick; Srinivasan Jayakumar; Cioffi, Christopher; O'Mara, Megan; Vandenberg, Robert
J.Neurochem. 2023, 00,1–20 https://doi.org/10.1111/jnc.16028

Novel Phenylene Lipids That Are Positive Allosteric Modulators of Glycine Receptors and Inhibitors of Glycine Transporter 2
Casey I. Gallagher, Zachary J. Frangos, Diba Sheipouri, Susan Shimmon, Meryem-Nur Duman, Srinivasan Jayakumar, Christopher L.Cioffi, Tristan Rawling, and Robert J. Vandenberg*
ACS Chem. Neurosci. 2023, 14, 15, 2634–2647 https://doi.org/10.1021/acschemneuro.3c00167

Bis(Benzofuran–1,3-N,N-heterocycle)s as Symmetric and Synthetic Drug Leads against Yellow Fever Virus.
Nitesh K. Gupta, Srinivasan Jayakumar, Wen-Chieh Huang, Pieter Leyssen,Johan Neyts, Sergey O. Bachurin, Jih Ru Hwu *, Shwu-Chen Tsay
Int. J. Mol. Sci. 2022, 23, 12675. https://doi.org/10.3390/ijms232012675

Identification of Transthyretin Tetramer Kinetic Stabilizers That Are Capable of Inhibiting the Retinol-Dependent Retinol Binding Protein 4-Transthyretin Interaction: Potential Novel Therapeutics for Macular Degeneration, Transthyretin Amyloidosis, and Their Common Age-Related Comorbidities

Christopher L. Cioffi, * Arun Raja, Parthasarathy Muthuraman, Aravindan Jayaraman, Srinivasan Jayakumar, Andras Varadi, Boglarka Racz, and Konstantin Petrukhin*
J. Med. Chem. 2021, 64, 13, 9010−9041. https://doi.org/10.1021/acs.jmedchem.1c00099

Enterovirus Inhibition by Hinged Aromatic Compounds with Polynuclei

Jih Ru Hwu*, Avijit Panja, Srinivasan Jayakumar, Shwu-Chen Tsay, Kui-Thong Tan, WenChieh Huang, Yu-Chen Hu, Pieter Leyssen and Johan Neyts*
Molecules 2020, 25, 3821; https://doi.org/10.3390/molecules25173821

Synthesis and Human Anticancer Cell Line Studies on Coumarin- −carboline Hybrids as Possible Antimitotic Agents.
S. Samundeeswari, Manohar V. Kulkarni*, Shrinivas D. Joshi, Sheshagiri R. Dixit, Srinivasan Jayakumar, and R. M. Ezhilarasi
ChemistrySelect 2016, 1, 5019-5024. https://doi.org/10.1002/slct.201601020