Our Innovations
1. Sequence controlled CISS based ds-DNA Detection
In this work, we have sought to establish a correlation between the value of spin polarization and variations in DNA sequences by developing a gold-coated ferromagnetic device to investigate the flow of electrons through a Quantum Dot (QD)-DNA system. Our results demonstrate that the degree of sequence-specific structural disruption in a DNA molecule is commensurate with the yield of spin polarization. Finally, our findings would contribute to the development of spin-based DNA-detecting technologies.
https://doi.org/10.1063/5.0157931
2.First Spin-based DNA Biosensor for Dengue Virus Detection
A label-free DNA hybridization sensor based on the CISS effect was built and utilized to detect the Dengue virus. The results of our research have been promising, and they can be applied in creating commercial spin-based DNA hybridization sensors.
https://doi.org/10.1016/j.snb.2023.133447
3. Cysteine-coated spin based Ni/Au device for water splitting
Our results indicate that cysteine coated bilayer Ni/Au films exhibit excellent catalytic behavior for both OER and HER with significant reduction in over potential and remarkable enhancement (∼11-fold for HER) in the current density value at a fixed potential. The observed phenomena have been rationalized by chiral-induced spin-specific reaction at the electrode's surface.
https://doi.org/10.1016/j.ijhydene.2021.08.219
4. CISS-modulated Time-Correlated Single Photon Counting based DNA Detection
Herein, we explore the role of CISS effect in time-correlated single photon counting measurements to detect DNA hybridization. We observe that the average lifetime of optical excited states of quantum dots attached to double-strand DNA (dsDNA) varies with the directions of the applied magnetic field. Specifically, the difference in the nonradiative average decay lifetime for the two orientations of the applied magnetic field is ≈ 2.21 ns in the case of hybridized strands, which is 130 times higher than that observed with quantum dots attached to single-strand DNA.
In this work, chiral-induced spin selectivity (CISS)-based label-free detection of radiation-induced DNA damage was demonstrated. The inherent correlation between the charge-transfer resistance (Rct) and the spin selectivity of electrons through DNA was taken into account for the detection of DNA damage for the first time with a limit of detection achieved up to 10 picomolar concentrations of DNA.
https://doi.org/10.1021/acsomega.2c04659
