Publications

On the Cover

Research Articles

[A61] Evaluation of a static mixer  as a new microfluidic method for liposome formulation

Aoba Ota, Ayaka Mochizuki, Keitaro Sou, Shinji Takeoka 

Frontiers in Bioengineering and Biotechnology, 11, 1229829 (2023).

doi/10.3389/fbioe.2023.1229829

[A60] Temperature-responsive liposome-linked immunosorbent assay for the rapid detection of SARS-CoV-2 using immunoliposomes 

Runkai Hu, Morihiro Hotta, Taro Maruyama, Mizuki Fujisawa, Keitaro Sou, Shinji Takeoka 

ACS Omega, 7, 26936-26944 (2022).

doi/10.1021/acsomega.2c03597

[A59] Squaraine probes for the bimodal staining of lipid droplets and endoplasmic reticulum imaging in live cells 

Ferdinandus, Jie Ren Tan, Jin Heng Lim, Satoshi Arai, Keitaro Sou, Chi-Lik Ken Lee 

Analyst, 147, 3570-3577 (2022).

doi.org/10.1039/D2AN00803C

[A58] A rapid and highly sensitive biomarker detection platform based on a temperature-responsive liposome-linked immunosorbent assay 

Runkai Hu, Keitaro Sou, Shinji Takeoka

Scientific Reports, 10, 18086 (2020).

doi: 10.1038/s41598-020-5441875011-x

[A57] Nanocapsule pH regulator: Sustained continuous alkali release from thermosensitive liposomes reduces acid erosion 

Jian Rong Chong, Duc Long Le, Hirotaka Sato, Keitaro Sou

ACS Applied Materials & Interfaces, 12(19), 21463-21469 (2020).

doi.org/10.1021/acsami.0c03814

[A56] Electrochemical system encapsulated by nanoscale liposomes enabling on-demand triggering of electroless deposition at selected areas 

Jing Zhan, Ming Lin, Satoshi Arai, Wei Yang Wan, Keitaro Sou, Hirotaka Sato

ACS Applied Nano Materials, 3(6), 5098-5106 (2020).

doi.org/10.1021/acsanm.0c00366

[A55] Nano capsule based chemical releasing system for insect-computer hybrid robot

Duc Long Le, Keitaro Sou, Hirotaka Sato

2020 IEEE 33rd International Conference on Micro Electro Mechanical Systems (MEMS), 433-436 (2020).

doi: 10.1109/MEMS46641.2020.9056335

[A54] Highly cooperative fluorescence switching of self-assembled squaraine dye at tunable threshold temperatures using thermosensitive nanovesicles for optical sensing and imaging

Keitaro Sou, Li Yan Chan, Satoshi Arai, Chi-Lik Ken Lee

Scientific Reports, 9, 17991 (2019).

doi: 10.1038/s41598-019-54418-1

[A53] An assay to evaluate the function of liposomal platelet substitutes delivered to platelet aggregates

Suyun Janet Tan, Keiko Nakahara, Keitaro Sou, Shinji Takeoka

Frontiers in Bioengineering and Biotechnology, 7, 77 (2019).

doi:10.3389/fbioe.2019.0007

[A52] Nanocapsules for programmed neurotransmitter release: Toward artificial extracellular synaptic vesicles 

Keitaro Sou, Duc Long Le, Hirotaka Sato

Small, 15(17), 1900132 (2019).

doi:10.1002/smll.201900132

Featured on the inside front cover of the journal. [Link]

Abstract Image

[A51] Neurotransmitter-loaded nanocapsule triggers on-demand muscle relaxation in living organism

Duc Long Le, Ferdinandus, Chin Kiat Tnee, T. Thang Vo Doan, Satoshi Arai, Madoka Suzuki, Keitaro Sou, Hirotaka Sato

ACS Applied Materials & Interfaces, 10(44), 37812-37819 (2018).

doi:10.1021/acsami.8b11079

[A50] Near infrared fluorophore-tagged chloroquine in Plasmodium falciparum diagnostic imaging 

Li Yan Chan, Joshua Ding Wei Teo, Kevin Shyong-Wei Tan, Keitaro Sou, Wei Lek Kwan, Chi-Lik Ken Lee

Molecules, 23(10), 2635 (2018).

doi:10.3390/molecules23102635

[A49] Development of temperature-responsive liposomes and their application for drug delivery system

Keitaro Sou

Artificial Blood 26(1), 47-54 (2018) (in Japanese).

温度応答性リポソームの開発と薬物送達システムへの応用

宗 慶太郎

人工血液 26(1), 47-54 (2018).

[A48] Far-red fluorescent liposomes for folate receptor-targeted bioimaging

Sheng Dong, Joshua Ding Wei Teo, Li Yan Chan, Chi-Lik Ken Lee, Keitaro Sou

ACS Applied Nano Materials 1(3), 1009-1013 (2018). 

doi:10.1021/acsanm.8b00084

Abstract Image

[A47] Photo-switchable and self-erasable fluorescent nanoprobe

Keitaro Sou, Li Yan Chan, Chi-Lik Ken Lee

Journal of Photochemistry and Photobiology A: Chemistry, 332, 25-31 (2017). 

doi:10.1016/j.jphotochem.2016.08.001

image

[A46] Temperature tracking in a three-dimensional matrix using thermosensitive liposome platform

Keitaro Sou, Li Yan Chan, Chi-Lik Ken Lee

ACS Sensors, 1(6), 650-655  (2016). 

doi: 10.1021/acssensors.6b00222

Abstract Image

[A45] Thermosensitive nanoplatforms for photothermal release of cargo from liposomes under intracellular temperature monitoring 

Satoshi Arai, Chi-Lik Ken Lee, Young-Tae Chang, Hirotaka Sato, Keitaro Sou

RSC Advances, 5(113), 93530-93538 (2015).

doi: 10.1039/C5RA19729E

Graphical abstract: Thermosensitive nanoplatforms for photothermal release of cargo from liposomes under intracellular temperature monitoring

[A44] Establishment of a total liquid ventilation system using saline-based oxygen micro/nano-bubble dispersions in rats

Kenta Kakiuchi, Kenichi Matsuda, Norikazu Harii, Keitaro Sou, Junko Aoki, Shinji Takeoka

Journal of Artificial Organs 18(3), 220-227 (2015).

doi: 10.1007/s10047-015-0835-z

[A43] Engineered liposomes for drug delivery and biomedical imaging

Keitaro Sou

Recent Patents on Nanomedicine 4(2), 95-101 (2015).

doi: 10.2174/1877912305666150121001827

[A42] Therapeutic impact of erythropoietin-encapsulated liposomes targeted to bone marrow on renal anemia

Yuri Miyazaki, Kazuaki Taguchi, Keitaro Sou, Hiroshi Watanabe, Yu Ishima, Toshikazu Miyakawa, Hiroaki Mitsuya, Masafumi Fukagawa, Masaki Otagiri, Toru Maruyama

Molecular Pharmaceutics 11(11), 4238-4248 (2014).

doi: 10.1021/mp500453a

Abstract Image

[A41] Application of surface-modified liposomes with succinic acid for drug delivery system targeting bone marrow 

Keitaro Sou

Membrane 39(5), 290-295 (2014) (in Japanese).

コハク酸で表面修飾したリポソームの骨髄標的化DDSへの応用

宗 慶太郎

, 39(5), 290-295 (2014).

[A40] Cationic amino acid-based lipids as effective non-viral gene delivery vectors for primary neurons

Yumiko Aoshima, Ryosuke Hokama, Keitaro Sou, Satya Ranjan Sarker, Kabuto Iida, Hideki Nakamura, Takafumi Inoue, Shinji Takeoka

ACS Chemical Neuroscience 4(12), 1514-1519 (2013).

doi: 10.1021/cn400036j

Featured on the cover of the journal.

Abstract Image

[A39] Arginine-based cationic liposomes for efficient in vitro plasmid DNA delivery with low cytotoxicity

Satya Ranjan Sarker, Yumiko Aoshima, Ryosuke Hokama, Takafumi Inoue, Keitaro Sou, Shinji Takeoka

International Journal of Nanomedicine 8, 1361-1375 (2013).

doi: 10.2147/IJN.S38903

[A38] Cardiopulmonary hemodynamic responses to the small injection of hemoglobin-vesicles (artificial oxygen carriers) in miniature pigs

Hiromi Sakai, Yuji Suzuki, Keitaro Sou, Mayumi Kano

Journal of Biomedical Materials Research Part A 100(10), 2668-2677 (2012).

doi: 10.1002/jbm.a.34208

[A37] Curcumin towards nanomedicine

Keitaro Sou

Recent Patents on Nanomedicine 2(2), 133-145 (2012).

doi: 10.2174/1877912311202020133

[A36] Removal of cellular-type hemoglobin-based oxygen carrier (hemoglobin-vesicles) from blood by using centrifugation and ultrafiltration

Hiromi Sakai, Keitaro Sou, Hirohisa Horinouchi, Eishun Tsuchida, Koichi Kobayashi

Artificial Organs 36(2), 202-209 (2012).

doi: 10.1111/j.1525-1594.2011.01236.x

[A35] Phagocytosis of liposome particles by rat splenic immature monocytes makes them transiently and highly immunosuppressive

Daisuke Takahashi, Hiroshi Azuma, Hiromi Sakai, Keitaro Sou, Daiko Wakita, Hideki Abe, Mitsuhiro Fujihara, Hirohisa Horinouchi, Takashi Nishimura, Koichi Kobayashi, Hisami Ikeda

The Journal of Pharmacology and Experimental Therapeutics, 337(1), 42-49 (2011).

doi: 10.1124/jpet.110.172510

[A34] Electrostatics of carboxylated anionic vesicles for improving entrapment capacity

Keitaro Sou

Chemistry and Physics of Lipids, 164(3), 211-215 (2011).

doi: 10.1016/j.chemphyslip.2011.01.002

[A33] Bone marrow-targeted liposomal carriers

Keitaro Sou, Beth Goins, Babatunde O Oyajobi, Bruno L Travi, and William T Phillips

Expert Opinion on Drug Delivery 8(3), 317-328 (2011).

doi: 10.1517/17425247.2011.553218

[A32] Hemoglobin-vesicle, a cellular artificial oxygen carrier, that fulfils the physiological roles of the red blood cells structure

Hiromi Sakai, Keitaro Sou, Hirohisa Horinouchi, Koichi Kobayashi, Eishun Tsuchida

Advances in Experimental Medicine and Biology 662, 433-438 (2010).

doi: 10.1007/978-1-4419-1241-1_62

[A31] Bone marrow-targeted drug delivery carriers based on liposome technology

Keitaro Sou

Artificial Blood 18(4), 134-141 (2010) (in Japanese).

リポソーム技術を基盤とする骨髄指向性薬物送達キャリアー

宗 慶太郎

人工血液, 18(4), 134-141 (2010).

[A30] Bone marrow-targeted liposomal carriers: A feasibility study in nonhuman primates

Keitaro Sou, Beth Goins, Michelle M Leland, Eishun Tsuchida, William T Phillips

Nanomedicine 5(1), 41-49 (2010).

doi: 10.2217/nnm.09.78

[A29] Artificial oxygen carriers, hemoglobin vesicles and albumin-hemes based on bioconjugate chemistry 

Eishun Tsuchida, Keitaro Sou, Akito Nakagawa, Hiromi Sakai, Teruyuki Komatsu, Koichi Kobayashi

Bioconjugate Chemistry 20(8), 1419-1440 (2009).

doi: 10.1021/bc800431d

Featured on the cover of the journal.

[A28] Static structure and dynamics of hemoglobin vesicle (HbV) developed as a transfusion alternative

Takaaki Sato, Hiromi Sakai, Keitaro Sou, Matrin Medebach, Otto Glatter, Eishun Tsuchida

The Journal of Physical Chemistry B. 113(24), 8418-8428 (2009).

doi: 10.1021/jp9002142

[A27] Review of hemoglobin-vesicles as artificial oxygen carriers

Hiromi Sakai, Keitaro Sou, Hirohisa Horinouchi, Koichi Kobayashi, Eishun Tsuchida

Artificial Organs 33(2),139-145 (2009).

doi: 10.1111/j.1525-1594.2008.00698.x

[A26] Clinical laboratory test of blood specimens containing hemoglobin-vesicles. Interference avoidance by addition of dextran

Keitaro Sou, Risa Komine, Hiromi Sakai, Koichi Kobayashi, Eishun Tsuchida, Mitsuru Murata

Artificial Blood 17(1), 6-15 (2009) (in Japanese).

ヘモグロビン小胞体を含有する血液検体の臨床検査-デキストラン添加による干渉作用の回避

宗 慶太郎, 小峰梨沙, 酒井宏水, 小林紘一, 土田英俊, 村田 満

人工血液, 17(1), 6-15 (2009).

[A25] Characterization and cytotoxicity of self-organized assemblies of curcumin and amphiphatic poly(ethylene glycol)

Keitaro Sou, Babatunde O Oyajobi, Beth Goins, William T Phillips, Eishun Tsuchida

Journal of Biomedical Nanotechnology 5(2), 202-208 (2009).

doi: 10.1166/jbn.2009.1025

[A24] Cerebral oxygen delivery by liposome-encapsulated hemoglobin: A positron-emission tomographic evaluation in a rat model of hemorrhagic shock

Keitaro Sou

Artificial Blood 16(3), 169-174 (2008) (in Japanese).

ヘモグロビン内包リポソームによる脳への酸素供給:出血性ショックラットモデルでのPETイメージングによる評価

宗 慶太郎

人工血液, 16(3), 169-174 (2008).

[A23] Electrostatic interactions and complement activation on the surface of phospholipid vesicles containing acidic lipids: Effect of the structure of acidic groups

Keitaro Sou, EishunTsuchida

Biochimica et Biophysica Acta-Biomembranes, 1778(4), 1035-1041 (2008).

doi: 10.1016/j.bbamem.2008.01.006

[A22] Loading of curcumin into macrophages using lipid-based nanoparticles

Keitaro Sou, Shunsuke Inenaga, Shinji Takeoka, Eishun Tsuchida

International Journal of Pharmaceutics, 352(1-2), 287-293 (2008). 

doi: 10.1016/j.ijpharm.2007.10.033

[A21] Hemoglobin-vesicles as artificial oxygen carriers: Present situation and future vision

Hiromi Sakai, Keitaro Sou, Hirohisa Horinouchi, Koichi Kobayashi, Eishun Tsuchida

Journal of Internal Medicine, 263(1), 4-15 (2008).

doi: 10.1111/j.1365-2796.2007.01893.x

Featured on the cover of the journal.

[A20] Selective uptake of surface-modified phospholipid vesicles by bone marrow macrophages in vivo

Keitaro Sou, Beth Goins, Shinji Takeoka, Eishun Tsuchida, William T Phillips

Biomaterials, 28(16), 2655-2666 (2007).

doi: 10.1016/j.biomaterials.2007.01.041.

[A19] Poly(ethylene glycol)-conjugated phospholipids in aqueous micellar solutions: Hydration, static Structure, and interparticle interactions

Takaaki Sato, Hiromi Sakai, Keitaro Sou, Richard Buchner, Eishun Tsuchida

The Journal of Physical Chemistry B, 111(6), 1393-1401 (2007).

doi: 10.1021/jp067011k

[A18] Solution to the problems of acellular Hbs by encapsulation, and the intrinsic issues of Hb-vesicles as a molecular assembly

Hiromi Sakai, Keitaro Sou, Eishun Tsuchida

Transfusion Alternative in Transfusion Medicine, 9(4), 226-236 (2007).

doi: 10.1111/j.1778-428X.2007.00089.x

[A17] Circulation kinetics and organ distribution of Hb-vesicles developed as a red blood cell substitute

Keitaro Sou, Robert Klipper, Beth Goins, Eishun Tsuchida, William T Phillips

The Journal of Pharmacology and Experimental Therapeutics, 312(2), 702-709 (2005).

doi: 10.1124/jpet.104.074534

[A16] Oxygen infusions (hemoglobin-vesicles and albumin-hemes) based on nano-molecular sciences

Eishun Tsuchida, Hiromi Sakai, Teruyuki Komatsu, Shinji Takeoka, Yubin Huang, Keitaro Sou, Akito Nakagawa, Yuji Teramura, Koichi Kobayashi

Polymers for Advanced Technologies, 16(2-3), 73-83 (2005).

doi: 10.1002/pat.559

[A15] Physiologic capacity of reticuloendothelial system for degradation of hemoglobin-vesicles (artificial oxygen carriers) after massive intravenous doses by daily repeated infusions for 14 days

Hiromi Sakai, Yohei Masada, Hirohisa Horinouchi, Eiji Ikeda, Keitaro Sou, Shinji Takeoka, Makoto Suematsu, Masuhiko Takaori, Koichi Kobayashi,  Eishun Tsuchida

The Journal of Pharmacology and Experimental Therapeutics, 311(3), 874-884 (2004).

doi: 10.1124/jpet.104.073049

[A14] Detection of lipopolysaccharide in hemoglobin-vesicles by Limulus amebocyte lysate test with kinetic-turbidimetric gel clotting analysis and pretreatment with a surfactant

Hiromi Sakai, Shuji Hisamoto, Ippei Fukutomi, Keitaro Sou, Shinji Takeoka, Eishun Tsuchida

Journal of Pharmaceutical Science, 93(2), 310-321 (2004).

doi: 10.1002/jps.10525

[A13] Effective encapsulation of proteins into size-controlled phospholipid vesicles using the freeze-thawing and extrusion

Keitaro Sou, Yoshiyasu Naito, Taro Endo, Shinji Takeoka, Eishun Tsuchida

Biotechnology Progress, 19(5), 1547-1552 (2003).

doi: 10.1021/bp0201004

[A12] Detection of lipopolysaccharide contaminating hemoglobin-vesicles as artificial oxygen carriers

Shuji Hisamoto, Hiromi Sakai, Ippei Fukutomi, Keitaro Sou, ShinjiTakeoka, Eishun Tsuchida

Artificial Blood, 11(3), 173-178 (2003) (in Japanese).

酸素輸液ヘモグロビン小胞体に混在するリポポリサッカライドの定量法

久本秀治, 酒井宏水, 福富一平, 宗 慶太郎, 武岡真司, 土田英俊

人工血液, 11(3), 173-178 (2003).

[A11] Safety of oxygen infusion (artificial red cells) and the ability to supply oxygen to tissues

Eishun Tsuchida, Keitaro Sou, Hiromi Sakai, Teruyuki Komatsu, Shinji Takeoka, Hirohisa Horinouchi, Makoto Suematsu, Koichi Kobayashi

Masui. The Japanese journal of anesthesiology, 52, 55-66 (2003) (in Japanese).

酸素輸液(人工赤血球)の安全度 と 体組織への酸素供給

土田英俊, 宗 慶太郎, 酒井宏水, 小松晃之, 武岡真司, 堀之内宏久, 末松 誠, 小林紘一

麻酔 増刊号, 52, 55-66 (2003).

[A10] Oxygen infusion (artificial red cells)

Eishun Tsuchida, Hiromi Sakai, Shinji Takeoka, Keitaro Sou, Koichi Kobayashi

Igaku no Ayumi, 205(9), 558-566 (2003) (in Japanese).

酸素輸液(人工赤血球)

土田英俊, 酒井宏水, 武岡真司, 宗 慶太郎, 小林紘一

医学のあゆみ, 205(9), 558-566 (2003). 

[A9] Report: Vlllth international symposium on blood substitutes (Vlll-lSBS)

Keitaro Sou

Artificial Blood, 9(1), 30-31 (2001) (in Japanese).

学会報告:第8回血液代替物国際会議

宗 慶太郎

人工血液, 9(1), 30-31 (2001).

[A8] Poly(ethylene glycol)-modification of the phospholipid vesicles by using the spontaneous incorporation of poly(ethylene glycol)-lipid into the vesicles

Keitaro Sou, Taro Endo, Shinji Takeoka, Eishun Tsuchida

Bioconjugate Chemistry, 11(3), 372-379 (2000).

doi: 10.1021/bc990135y

[A7] Synthesis and assembly of poly(ethylene glycol)-lipids with mono-, di-, and tetraacyl chains and a poly(ethylene glycol) chain of various molecular weights

Shinji Takeoka, Katsura Mori, Haruki Ohkawa, Keitaro Sou, Eishun Tsuchida

Journal of the American Chemical Society, 122(33), 7927-7935 (2000).

doi: 10.1021/ja000835+

[A6] Poly(ethylene glycol)-conjugation and deoxygenation enable long term preservation of hemoglobin-vesicles as oxygen carriers in a liquid state

Hiromi Sakai, Ken-ichi Tomiyama, Keitaro Sou, Shinji Takeoka, Eishun Tsuchida

Bioconjugate Chemistry,11(3), 425-432 (2000).

doi: 10.1021/bc990173h

[A5] Long term preservation of oxygen infusion (hemoglobin-vesicles) achieve by poly(oxyethylene)-conjugation and deoxygenation

Hiromi Sakai, Ken-ichi Tomiyama, Keitaro Sou, Shinji Takeoka, Eishun Tsuchida

Artificial Blood, 7(4), 95-100 (1999) (in Japanese).

ポリオキシエチレン修飾と脱酸素化による酸素輸液(ヘモグロビン小胞体)の長期保存

酒井宏水, 富山賢一, 宗 慶太郎, 武岡真司, 土田英俊

人工血液, 7(4), 95-100 (1999). 

[A4] Disk-like assemblies of a synthetic glycolipid and their association with Concanavalin A

Shinji Takeoka, Keitaro Sou, Takeru Ohgushi, Eishun Tsuchida

Supramolecular Science, 5(1-2), 159-162 (1998).

doi: 10.1016/S0968-5677(97)00001-1

[A3] Physical properties and packing states of molecular assemblies of synthetic glycolipid in aqueous dispersions

Shinji Takeoka, Keitaro Sou, Christoph Boettcher, Jurgen-Hinrich Fuhrhop, Eishun Tsuchida

Journal of the Chemical Society, Faraday Transactions, 94(15), 2151-2158 (1998).

doi: 10.1039/A800289D

[A2] Effect of surface-modification of hemoglobin-vesicles (HbV) with polyethyleneglycol-lipid or glycolipid

Sung Ick Park, Keitaro Sou, Hiromi Sakai, Shinji Takeoka, Hiroyuki Nishide, Eishun Tsuchida

Artificial Blood, 4(1), 9-14 (1996) (in Japanese).

ポリエチレングリコール型脂質および糖脂質によるヘモグロビン小胞体(HbV)の表面修飾効果

朴 晟翼, 宗 慶太郎, 酒井宏水, 武岡真司, 西出宏之, 土田英俊

人工血液, 4(1), 9-14 (1996). 

[A1] Critical molecular weight effects in the aggregation of phospholipid vesicles triggered by water-soluble polymers and an integrated glycolipid

Shinji Takeoka, Keitaro Sou, Shinya Arase, Takeru Ohgushi, Eishun Tsuchida

Macromolecules, 29(25), 8132-8136 (1996). 

doi: 10.1021/ma961064q

Book Chapters

[B10] リポソーム製剤の骨髄へのDDS応用

宗 慶太郎, 田口和明

In: DDS先端技術の製剤への応用開発 第6章 6節, 技術情報協会 360-368 (2017). ISBN: 978-4-86104-663-6

[B9] Radiolabeled liposomes as drug delivery nano-theranostics

William T Phillips, Ande Bao, Keitaro Sou, Shihong Li, Beth Goins

In: Drug Delivery Applications of Noninvasive Imaging: Validation from Biodistribution to Sites of Action, Chapter 11 (Eds. By C. Li and M. Tian, John Wiley & Sons)  252-267 (2013). ISBN: 978-0-470-63347-2

[B8] Advanced drug carriers targeting bone marrow 

Keitaro Sou

In: Recent Advances in Novel Drug Carrier Systems, Chapter 15 (Ed. By A.D. Sezer, InTech) 419-436 (2012). ISBN: 979-953-307-1092-8.

doi: 10.5772/51206

[B7] Radiolabeled liposomes as theranostic agents

William T Phillips, Beth Goins, Keitaro Sou, Ande Bao

In: Nanoimaging, Chapter 4 (Eds. By B. Goins and W.T. Phillips, Pan Stanford Publishing Pte Ltd.) 71-108 (2011). ISBN: 9789814267090.

[B6] 人工赤血球

酒井宏水, 宗 慶太郎, 武岡真司, 小林紘一, 土田英俊

In: 医療分野における材料と機能膜 第5章, シーエムシー出版 107-118 (2011). ISBN:978-4-7813-0335-2. 

[B5] Hemoglobin vesicles as an artificial oxygen carrier

Hiromi Sakai, Keitaro Sou, Eishun Tsuchida

In: Methods in Enzymology (Ed. by N. Duzgunes, Elsevier, Academic Press), 465, 363-384 (2009). ISBN: 978-0123813794.

doi: 10.1016/S0076-6879(09)65019-9

[B4] Hemoglobin-vesicles as a molecular assembly: characteristics of preparation process and performances as artificial oxygen carriers

Hiromi Sakai, Keitaro Sou, Shinji Takeoka, Koichi Kobayashi, Eishun Tsuchida

In: Blood Substitutes, Chapter 44 (Ed. By Robert M. Winslow, Elsevier, Academic Press) 514-522 (2005). ISBN: 978-0-12-759760-7.

doi: 10.1016/B978-012759760-7/50055-X

[B3] 人工赤血球

酒井宏水, 宗 慶太郎, 武岡真司, 小林紘一, 土田英俊

In: 医療用マテリアルと機能膜 第II編 人工臓器 第5章, シーエムシー出版107-118 (2005). ISBN: 978-4-88231-503-2. 

[B2] Hemoglobin-vesicles (HbV) as artificial oxygen carriers

Hiromi Sakai, Keitaro Sou, Shinji Takeoka, Koichi Kobayashi, Eishun Tsuchida

In: Artificial Oxygen Carrier, Its Front line: Keio University International Symposia for Life Sciences and Medicine Vol.12, (Eds. By K. Kobayashi, E. Tsuchida, H. Horinouchi, Springer-Verlag) 135-168 (2005). ISBN: 978-4-431-26651-8.

doi: 10.1007/4-431-26651-8_10

[B1] Safety and efficacy of hemoglobin-vesicles and albumin-hemes

Koichi Kobayashi, Hirohisa Horinouchi, Masazumi Watanabe, Yotaro Izumi, Yuji Teramura, Akito Nakagawa, Yubin Huang, Keitaro Sou, Hiromi Sakai, Teruyuki Komatsu, Shinji Takeoka, Eishun Tsuchida

In: Artificial Oxygen Carrier, Its Front line: Keio University International Symposia for Life Sciences and Medicine Vol.12, (Eds. By K. Kobayashi, E. Tsuchida, H. Horinouchi, Springer-Verlag) 1-21(2005). ISBN: 978-4-431-26651-8.

doi: 10.1007/4-431-26651-8_1

Patents

[P10] 温度応答性蛍光粒子を用いた生体分子の同時検出方法 

S. Takeoka, K. Sou, T. Maruyama

JP特願2023-139373

[P9] 生体分子検出のための温度応答性蛍光粒子

S. Takeoka, K. Sou, R. Hu, C.L.K. Lee, L.Y. Chan

特許第7284470号; PCT/JP2020/021358

[P8] Bone marrow-directing drug delivery materials and their applications

K. Sou, S. Takeoka, E. Tsuchida, B. Goins, W.T. Phillips

US2009/0297608; EP1906924; JP2008-542360

[P7] Zwitterionic lipid compound and uses thereof

E. Tsuchida, S. Takeoka, K. Sou, K. Mori 

US 6,965,049; EP1219659; JP2001-064383

[P6] Carboxylic acid-type lipid

E. Tsuchida, S. Takeoka, K. Sou, H. Ohkawa, K. Mori 

US6949663; EP1340740; JP4226324 

[P5] Amphiphilic compounds having a dendritic branch structure

E. Tsuchida, S. Takeoka, K. Sou, H. Ohkawa

US6933352; EP1219659; JP3181276

[P4] Method for Preserving oxygen infusions

E. Tsuchida, H. Sakai, K. Tomiyama, S. Takeoka, K. Sou 

US6864049; CA2383977; JP3466516 

[P3] Method for producing a vesicle dispersion

E. Tsuchida, S. Takeoka, K. Sou, T. Endo, Y. Naito 

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