Soto Lab Publications

Murray CE, Betancourt-Trompa DS, Martinez MS, Carson JM, Walsh LJ, Remillard WC, Fordyce KB, Reddy R, Soto I. Role of mTORC1 signaling in postnatal microglia activation preceding neurodegeneration in a mouse model for Niemann-Pick disease Type C. PLOS One. 2025 Sep 5;20(9):e0330437. https://doi.org/10.1371/journal.pone.0330437

Walsh LJ, Espinal-San Miguel IM, Rodriguez AV, Peña UM, Flynn KE, Remillard WC, Brazier SR, Anderson NI, Clark AJ, De Varona TA, Soto I. PTEN deficiency in postnatally developing Purkinje cells disrupts metabolic signaling, leading to dendritic abnormalities and sex-specific behavioral deficits. Sci Rep. 2025 Jul 8;15(1):24460. 10.1038/s41598-025-09059-y

MacLeod CM, Yousufzai FAK, Spencer LT, Kim S, Rivera-Rosario LA, Barrera ZD, Walsh L, Krummenacher C, Carone B, Soto I (2023). Trehalose enhances mitochondrial deficits in human NPC1 mutant fibroblasts but disrupts mouse Purkinje cell dendritic growth ex vivo. PLOS One. 18(11):e0294312. 10.1371/journal.pone.0294312

Kim S, Ochoa K, Melli SE, Yousufzai FAK, Barrera ZD, Williams AA, McIntyre G, Delgado E, Bolish JN, Macleod CM, Boghos M, Lens HP, Ramos AG, Wilson VB, Maloney K, Padron ZM, Khan AH, Blanco RE, Soto I (2023). Disruptive lysosomal-metabolic signaling and neurodevelopmental deficits that precede Purkinje cell loss in a mouse model of Niemann-Pick Type-C disease. Sci Rep. 13(1):5665. 10.1038/s41598-023-32971-0

Boyle BR, Melli SE, Altreche RS, Padron ZM, Yousufzai FAK, Kim S, Vasquez MD, Carone DM, Carone BR and Soto I (2020). NPC1 deficiency impairs cerebellar postnatal development of microglia and climbing fiber refinement in a mouse model of Niemann-Pick Type C disease. Development. 147 (21): dev189019. 10.1242/dev.189019

Kavetsky L, Green KK, Boyle BR, Yousufzai FAK, Padron ZM, Melli SE, Kuhnel VL, Jackson HM, Blanco RE, Howell GR, Soto I (2019). Increased interactions and engulfment of dendrites by microglia precede Purkinje cell degeneration in a mouse model of Niemann Pick Type-C. Sci Rep. 9(1):14722.  10.1038/s41598-019-51246-1