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Why we research for biomolecular condensates?
Biomolecular condensates are believed to perform various physiological functions within the cell such as compartmentalization, regulation of biochemical reactions, dynamic response to cellular signals, gene regulation, and stress response.
The formation of condensates is likely to be controlled by protein domains of their components, and we elucidate their molecular grammar.
Components and mechanisms of P-body formation differ between chronic aging and external stress.
Nst1 of budding yeast associates with P-body components to form biomolecular condensates in response to aging-related stress, but not under glucose deprivation.
Nst1 is densely associated with P-bodies of yeast cells.
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