Publication

Under Review

Han-Eol Park¹, Yu Tak Lee¹, Junsuk Lee, Hyelin Ji, Young-Lan Song, Jae Won Lee, Sung-Yon Kim, Junho K. Hur, Eunha Kim, Chung Whan Lee, Yoon Dae Han, Hyunki Kim, and Chang Ho Sohn*. Fixative eXchange (FX)-seq: scalable single-nucleus RNA sequencing enables transcriptome profiling of heavily PFA-fixed or FFPE mouse brain and human cancer tissue. bioRxiv 2026.03.05.709668 [Preprint]. https://www.biorxiv.org/content/10.64898/2026.03.05.709668v1

​Published

Verkhratsky, A., Lee, C. J., Chun, H., Göritz, C., Harkany, T., Lee, J.-H., Lee, S., Lindskog, M., Koh, W., Mulder, J., Nam, M.-H., Ottersen, O. P., Pekna, M., Pekny, M., Pękowska, A., Ryu, H., Sohn, C. H., Tretiakov, E. O., Untiet, V., Viney, T. J., Youn, W., Yi, C., Zorec, R., Yun, M., Cheong, E., & Nordberg, A. Curing the brain: in search for new astrocyte-specific therapies. Experimental & Molecular Medicine, 58, 1086–1127. https://doi.org/10.1038/s12276-026-01712-4 

Han-Eol Park¹, Yu Tak Lee¹, Junsuk Lee, Hyelin Ji, Young-Lan Song, Jae Won Lee, Sung-Yon Kim, Junho K. Hur, Eunha Kim, Chung Whan Lee, Yoon Dae Han, Hyunki Kim, and Chang Ho Sohn*. Fixative eXchange (FX)-seq: scalable single-nucleus RNA sequencing enables transcriptome profiling of heavily PFA-fixed or FFPE mouse brain and human cancer tissue. bioRxiv 2026.03.05.709668 [Preprint]. doi: https://doi.org/10.64898/2026.03.05.709668 

Dongsu Lee, Kyung Ah Han, Hyeonyeong Jeong, Go Eun Ha, Hyeongjin Lee, Beom Soo Kim, Chanmi Park, Yao Piao, Haeun Lee, Joon Kim, Taek Han Yoon, Seungjoon Kim, Byeongchan Kim, Jungsu Shin, Yujin Cho, Sunghyun Kang, Han-Eol Park, Ji Won Um, Chang Ho Sohn, John R. Huguenard, Jaewon Ko, Eunji Cheong. Juvenile-to-adult refinement of thalamic reticular circuits via LRRTM3 enables high-resolution sensory encoding. Neuron, 2026, ISSN 0896-6273, https://doi.org/10.1016/j.neuron.2025.12.020.

Dongwook Kim, Byeongchan Kim, Jinhu Kim, Na-Young Seo, Hyeonho Kim, Kyung Ah Han, Jubeen Yoon, Christian P. Macks, Joris de Wit, Chang Ho Sohn, Kea Joo Lee, Ji Won Um, Jaewon Ko. Paralogs of Slitrk cell adhesion molecules configure excitatory synapse specificity via distinct cellular mechanisms. PLOS Biology, 2025, 23(12): e3003576. DOI ​

​​Sungho Lee, Minjae Kim, Gha Yeon Park, Jubeen Yoon, Kunyoo Shin, Chang Ho Sohn*, and Myunghwan Choi* “Correlative Imaging Platform Linking Taste Cell Function to Molecular Identity.” Adv. Sci. (2025): e11309. DOI

Dae Hee Yun¹, Young-Gyun Park¹, Jae Hun Cho¹, Lee Kamentsky, Nicholas Evans, Nicholas DiNapoli, Katherine Xie, Seo Woo Choi, Alexandre Albanese, Yuxuan Tian, Chang Ho Sohn, Qiangge Zhang, Minyoung E. Kim, Justin Swaney, Webster Guan, Juhyuk Park, Gabi Drummond, Heejin Choi, Luzdary Ruelas, Guoping Feng, and Kwanghun Chung*. Uniform volumetric single-cell processing for organ-scale molecular phenotyping. Nat. Biotechnol., 2025, online. DOI

Hyelim Lee, Ju-Young Park, Jubeen Yoon, Wonjin Park, Miso Kang, Jeehee Lee, Gyubin Park, Minseob Koh, Hyejin Kim, Chang Ho Sohn, Sanghee Lee*, Eunha Kim*. Bioorthogonal imaging probe for STING protein in live cell and fixed tissue. Sensors Actuat. B Chem., 2024, 405, 135773. DOI

Kang-Hoon Kim¹, Jubeen Yoon¹, Christian P. Macks¹, Han-Eol Park, Jihyun Youn, Jung-uk Lee, Minji An, Jongseong Park, Jaewon Ko, and Chang Ho Sohn*. Molecular decrowding by tissue expansion allows precise determination of the spatial distribution of synaptic proteins at a nanometer scale by exTEM. ACS Nano, 2023, 17(10), 9919-9937. DOI

Han-Eol Park¹, Song Hyun Jo¹, Rosalind H. Lee¹, Christian P. Macks, Taeyun Ku, Jihwan Park, Chung Whan Lee, Junho K. Hur, and Chang Ho Sohn*. Spatial transcriptomics: technical aspects of recent developments and their applications in neuroscience and cancer research. Adv. Sci., 2023, 10(11), 2206939. DOI

Dongjoon Im, Soohyeong Kim, Gyusub Yoon, Da Gyeong Hyun, Yugon Eom, Chang Ho Sohn, Jeong-Mo Choi* and Hugh I. Kim*. Decoding the Roles of Amyloid-β (1-42)'s Key Oligomerization Domains Toward Designing Epitope-Specific Aggregation Inhibitors. JACS Au, 2023, 3(4), 1065-1075. DOI

Seongchan Kim, You Kyeong Jeong, Chang Sik Cho, SeokHoon Lee, Chang Ho Sohn, Jeong Hun Kim, Youngdo Jeong, Dong Hyun Jo*, Sangsu Bae*, and Hyojin Lee*. Enhancement of Gene Editing and Base Editing with Therapeutic Ribonucleoproteins... Adv. Healthcare Mater., 2023, 12(4), 2201825. DOI

Dongyup Shin, Hansol Choi, Jihun An, Chang Ho Sohn, Chang-Hyuck Choi, Hyeyoung Shin*, and Hyungjun Kim*. Enhanced Electroreduction of CO2 by Ni-N-C Catalysts from the Interplay Between Valency and Local Coordination Symmetry. J. Mater. Chem. A, 2022, 10, 22523-22530.

Alexandre Albanese, Justin M. Swaney, Dae Hee Yun, Nicholas B. Evans, Jenna M. Antonucci, Silvia Velasco, Chang Ho Sohn, Paola Arlotta, Lee Gehrke & Kwanghun Chung*. Multiscale 3D phenotyping of human cerebral organoids. Sci. Rep. 2020, 10, 21487.

Yandong Zhang¹, Chang Ho Sohn¹, Seoyeon Lee, Heejeong Ahn, Jinyoung Seo, Junyue Cao, and Long Cai*. Detecting protein and post-translational modifications in single cells with iDentification and qUantification sEparaTion (DUET). Commun. Biol., 2020, 3, 420. DOI

Taeyun Ku, Webster Guan, Nicholas B. Evans, Chang Ho Sohn, Alexandre Albanese, Matthew P. Frosch, and Kwanghun Chung*. Elasticizing tissues for reversible shape transformation and accelerated molecular labeling. Nat. Methods, 2020, 17, 609-613.

Young-Gyun Park¹, Chang Ho Sohn¹, Ritchie Chen¹, Margaret McCue, Dae Hee Yun, Gabrielle T. Drummond, Taeyun Ku, Nicholas B. Evans, Hayeon Caitlyn Oak, Wendy Trieu, Heejin Choi, Xin Jin, Varoth Lilascharoen, Ji Wang, Matthias C. Truttmann, Helena W. Qi, Hidde L. Ploegh, Todd R. Golub, Shih-Chi Chen, Matthew P. Frosch, Heather J. Kulik, Byung Kook Lim, Kwanghun Chung*. Protection of tissue physicochemical properties using polyfunctional crosslinkers. Nat. Biotechnol., 2019, 37, 73-83. DOI

Sowmya Chandrasekar, Michael J. Sweredoski, Chang Ho Sohn, Sonja Hess and Shu-ou Shan*. Co-evolution of two GTPases enables efficient protein targeting in an RNA-less chloroplast Signal Recognition Particle pathway. J. Biol. Chem., 2017, 292, 386-396.

Sheel Shah¹, Eric Lubeck¹, Maayan Schwarzkopf¹, Ting-Fang He¹, Alon Greenbaum¹, Chang Ho Sohn, Antti Lignell, Harry Choi, Viviana Gradinaru*, Niles Pierce*, and Long Cai*. Single-molecule RNA detection at depth via hybridization chain reaction and tissue hydrogel embedding and clearing. Development, 2016, 143, 2862-2867.

Yihan Lin, Chang Ho Sohn, Chiraj K. Dalal, Long Cai, and Michael B. Elowitz*. Combinatorial gene regulation by modulation of relative pulse timing. Nature, 2015, 527, 54-58.

Chang Ho Sohn, Sheng Yin, Ivory Peng, Joseph A. Loo and J. L. Beauchamp*. Investigation of the mechanism of electron capture and electron transfer dissociation of peptides with a covalently attached free radical hydrogen atom scavenger. Int. J. Mass Specrom., 2015, 390, 49-55.

Chang Ho Sohn, Jinshan Gao, Daniel A. Thomas, Tae-Young Kim, William A. Goddard III and J. L. Beauchamp*. Mechanisms and energetics of free radical initiated disulfide bond cleavage in model peptides and insulin by mass spectrometry. Chem. Sci., 2015, 6, 4550-4560.

Daniel A. Thomas, Chang Ho Sohn, and J. L. Beauchamp*. Hydrogen bonding constrains free radical reaction dynamics at serine and threonine residues in peptides. J. Phys. Chem. A 2014, 118, 8380-8392.

Paul J. Minor, Ting-Fang He, Chang Ho Sohn, Anand R. Asthagiri, Paul W. Sternberg*. FGF signaling upregulates Wnt in C. elegans vulval cell lineage polarity. Development 2013, 140, 3882-3891.

Jinshan Gao, Daniel A. Thomas, Chang Ho Sohn, and J. L. Beauchamp*. Biomimetic reagents for selective free radical and acid-base chemistry of glycans: application to glycan structure determination by mass spectrometry. J. Am. Chem. Soc. 2013, 135, 10684-10692.

Chang Ho Sohn¹, Heather D. Agnew¹, Geoffrey T. Smith, Michael J. Sweredoski, Robert L. Graham, Sonja Hess, Gregg Czerwieniec, Joseph A. Loo, Raymond J. Deshaies, James R. Heath and J. L. Beauchamp*. Designer reagents for mass spectrometry-based proteomics: clickable cross-linker for elucidation of protein structures and interactions. Anal. Chem. 2012, 84, 2662-2669.

Chang Ho Sohn, J. Eugene Lee, Geoffrey T. Smith, Michael J. Sweredoski, Robert L. Graham, Sonja Hess, Gregg Czerwieniec, Joseph A. Loo, Raymond J. Deshaies and J. L. Beauchamp*. Click chemistry facilitates formation of reporter ions and synthesis of amine-reactive multiplexed isobaric tags for protein quantification. J. Am. Chem. Soc., 2012, 134, 2672-2680.

Chang Ho Sohn, Cheol K. Chung, Sheng Yin, Prasanna Ramachandran, Joseph A. Loo and J. L. Beauchamp*. Probing the mechanism of electron capture and electron transfer dissociation using tags with variable electron affinity. J. Am. Chem. Soc., 2009, 131, 5444-5459