Publications

2019-Present

28. Tahtamouni LH*, Alderfer SA*, Kuhn TB, Minamide LS, Chanda S, Ruff MR, and Bamburg JR. Characterization of a human neuronal culture system for the study of Cofilin–Actin rod pathology. Biomedicines (2023); PMID: 38001943. *Co-first author.

27. Benner O*, Cast TP*, Minamide LS, Lenninger Z, Bamburg JR, and Chanda S. Multiple N-linked glycosylation sites critically modulate the synaptic abundance of Neuroligin isoforms. J Biol Chem (2023); PMID: 37865312. *Co-first author.

26. Mendez-Vazquez H*, Roach RL*, Nip K*, Chanda S, Sathler MF, Garver T, Danzman RA, Moseley MC, Roberts JP, Koch ON, Steger AA, Lee R, Arikkath J, and Kim S. The autism-associated loss of δ-catenin functions disrupts social behavior. Proc Natl Acad Sci USA (2023); PMID: 37216537. *Co-first author.

25. Haddad Derafshi B, Danko T, Chanda S, Batista PJ, Litzenburger U, Lee QY, Ng YH, Sebin A, Chang HY, Südhof TC, and Wernig M. The autism risk factor CHD8 is a chromatin activator in human neurons and functionally dependent on the ERK-MAPK pathway effector ELK1. Sci Rep (2022); PMID: 36575212.

24. Burlingham SR*, Wong NF*, Peterkin L*, Lubow L, Dos Santos Passos C, Benner O, Ghebrial M, Cast TP, Xu-Friedman MA#, Südhof TC#, and Chanda S#. Induction of synapse formation by de novo neurotransmitter synthesis. Nat Commun (2022); PMID: 35650274. *Co-first & #Co-corresponding author.

23. Ng YH, Chanda S, Janas JA, Yang N, Kokubu Y, Südhof TC, and Wernig M. Efficient generation of dopaminergic induced neuronal cells with midbrain characteristics. Stem Cell Reports (2021); PMID: 34171286.

22. Cast TP, Boesch DJ, Smyth K, Shaw AE, Ghebrial M, and Chanda S. An autism-associated mutation impairs Neuroligin-4 glycosylation and enhances excitatory synaptic transmission in human neurons. J Neurosci (2021); PMID: 33268543.

21. Lee QY*, Mall M*, Chanda S, Zhou B, Sharma KS, Schaukowitch K, Adrian-Segarra JM, Grieder SD, Kareta MS, Wapinski OL, Ang CE, Li R, Südhof TC, Chang HY, and Wernig M. Pro-neuronal activity of Myod1 due to promiscuous binding to neuronal genes. Nat Cell Biol (2020); PMID: 32231311. *Co-first author.

20. Marro SG*, Chanda S*, Yang N, Janas JA, Valperga G, Trotter J, Zhou B, Merrill S, Yousif I, Shelby H, Vogel H, Kalani MYS, Südhof TC, and Wernig M. Neuroligin-4 regulates excitatory synaptic transmission in human neurons. Neuron (2019); PMID: 31257103. *Co-first author.

19. Chanda S#, Ang CE, Lee QY, Ghebrial M, Haag D, Shibuya Y, Wernig M, and Südhof TC#. Direct reprogramming of human neurons identifies MARCKSL1 as a pathogenic mediator of valproic acid-induced teratogenicity. Cell Stem Cell (2019); PMID: 31155484. #Co-corresponding author.

2009-2018

18. Tanabe K*, Ang CE*, Chanda S, Olmos VH, Haag D, Levinson DF, Südhof TC, and Wernig M. Transdifferentiation of human adult peripheral blood T cells into neurons. Proc Natl Acad Sci USA (2018); PMID: 29866841. *Co-first author.

17. Chanda S#, Hale WD, Zhang B, Wernig M, and Südhof TC. Unique versus redundant functions of Neuroligin genes in shaping excitatory and inhibitory synapse properties. J Neurosci (2017); PMID: 28607166. #Corresponding author.

16. Yang N*, Chanda S*, Marro S, Ng YH, Janas JA, Haag D, Ang CE, Tang Y, Flores Q, Mall M, Wapinski O, Li M, Ahlenius H, Rubenstein JL, Chang HY, Buylla AA, Südhof TC, and Wernig M. Generation of pure GABAergic neurons by transcription factor programming. Nat Methods (2017); PMID: 28504679. *Co-first author.

15. Mall M, Kareta MS, Chanda S, Ahlenius H, Perotti N, Zhou B, Grieder SD, Ge X, Drake S, Ang CE, Walker BM, Vierbuchen T, Fuentes DR, Brennecke P, Nitta KR, Jolma A, Steinmetz LM, Taipale J, Südhof TC, and Wernig M. Myt1l safeguards neuronal identity by actively repressing many non-neuronal fates. Nature (2017); PMID: 28379941.

14. Chao MP, Gentles AJ, Chatterjee S, Lan F, Reinisch A, Corces MR, Xavy S, Shen J, Haag D, Chanda S, Sinha R, Morganti RM, Nishimura T, Ameen M, Wu H, Wernig M, Wu JC, and Majeti R. Human AML-iPSCs reacquire leukemic properties after differentiation and model clonal variation of disease. Cell Stem Cell (2017); PMID: 28089908.

13. Ahlenius H*, Chanda S*, Webb AE, Yousif I, Karmazin J, Prusiner SB, Brunet A, Südhof TC, and Wernig M. FoxO3 regulates neuronal reprogramming of cells from postnatal and aging mice. Proc Natl Acad Sci USA (2016); PMID: 27402759. *Co-first author.

12. Chanda S, Aoto J, Lee S, Wernig M, and Südhof TC. Pathogenic mechanism of an autism-associated Neuroligin mutation involves altered AMPA-receptor trafficking. Mol Psychiatry (2015); PMID: 25778475.

11. Chanda S*, Ang CE*, Davila J*, Pak C, Mall M, Lee QY, Ahlenius H, Jung SW, Südhof TC and Wernig M. Generation of induced neuronal cells by the single reprogramming factor Ascl1. Stem Cell Reports (2014); PMID: 25254342. *Co-first author.

10. Chanda S, Marro S, Wernig M, and Südhof TC. Neurons generated by direct conversion of fibroblasts reproduce synaptic phenotype caused by autism-associated neuroligin-3 mutation. Proc Natl Acad Sci USA (2013); PMID: 24046374.

9. Wapinski OL*, Vierbuchen T*, Qu K, Lee QY, Chanda S, Fuentes DR, Giresi PG, Ng YH, Marro S, Neff NF, Drechsel D, Martynoga B, Castro D, Webb AE, Südhof TC, Brunet A, Guillemot F, Chang HY, and Wernig M. Hierarchical mechanisms for transcription factor-mediated reprogramming of fibroblasts to neurons. Cell (2013); PMID: 24243019. *Co-first author.

8. Davila J, Chanda S, Ang CE, Südhof TC, and Wernig M. Acute reduction in oxygen tension enhances the induction of neurons from human fibroblasts. J Neurosci Methods (2013); PMID: 23562599.

7. Zhang Y, Pak C*, Han Y*, Ahlenius H, Zhang Z, Chanda S, Marro S, Patzke C, Acuna C, Covy J, Xu W, Yang N, Danko T, Chen L, Wernig M, and Südhof TC. Rapid single-step induction of functional neurons from human pluripotent stem cells. Neuron (2013); PMID: 23764284. *Equal contribution.

6. Lujan E, Chanda S, Ahlenius H, Südhof TC, and Wernig M. Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells. Proc Natl Acad Sci USA (2012); PMID: 22308465.

5. Chanda S and Xu-Friedman MA. Excitatory modulation in the Cochlear Nucleus through group I metabotropic glutamate receptor activation. J Neurosci (2011); PMID: 21593328.

4. Chanda S, Oh S, and Xu-Friedman MA. Calcium imaging of auditory nerve fiber terminals in the Cochlear Nucleus. J Neurosci Methods (2011); PMID: 21108967.

3. Chanda S and Xu-Friedman MA. Neuromodulation by GABA converts a relay into a coincidence detector. J Neurophysiol (2010); PMID: 20702743.

2. Chanda S and Xu-Friedman MA. A low-affinity antagonist reveals saturation and desensitization in mature synapses in the auditory brainstem. J Neurophysiol (2010); PMID: 20107122.

1. Strenzke N, Chanda S, Kopp-Scheinpflug C, Khimich D, Reim K, Bulankina AV, Neef A, Wolf F, Brose N, Xu-Friedman MA, and Moser T. Complexin-I is required for high-fidelity transmission at the endbulb of Held auditory synapse. J Neurosci (2009); PMID: 19553439.