Neuronal Development and Dysfunction
Our research objectives fall in the intersection of basic and translational neuroscience. We broadly study several aspects of the neurodevelopmental process, e.g. cellular mechanisms that regulate neuronal function, molecular contributions that determine neuronal specifications, and pathogenic effects of disease-associated genetic mutations that impair neuronal properties. We are also interested in developing novel protocols to directly convert non-neuronal somatic cells or embryonic/induced pluripotent stem (ES/iPS, respectively) cells into human neurons, and using these transdifferentiated neurons to gain mechanistic insights into human neurodevelopment and neurological disorders. Our work employs interdisciplinary techniques, e.g. cellular reprogramming, electrophysiology, high-resolution imaging, molecular biology, gene-expression, and biochemical analyses.
A class of synaptic cell-adhesion molecules regulates the postsynaptic clustering of neurotransmitter receptors
Ectopic expression of a single transcription factor can reprogram non-neuronal cells into functional neurons
An autism-associated genetic mutation alters the synaptic properties of stem cell-derived human neuronal subtypes
Human neurons generated from stem cells can reveal the harmful effects of teratogenic drugs during pregnancy