Low-Intensity Focused Ultrasound Neuromodulation for Tic Disorder Therapy: Preclinical Validation with Clinically Relevant Parameters. 

Soobin Park*, Miseon Kang*, Meonghyeon, Yehhyun Jo,  Jeongyeon Kim*, Hyunjoo Jenny Lee*

IEEE TNSRE. 2025 Oct 27 (accepted) 

Role of phospholipase Cη1 in lateral habenula astrocytes in depressive-like behavior in mice.

Song S*, Kang M*, Lee J*, Yang YR, Lee H, Kim JI, Kim B, Choi HS, Hong EB, Nam MH, Suh PG, Kim J.* 

Exp Mol Med. 2025 April 10 

Aberrant ERK signaling in astrocytes impairs learning and memory in RASopathy-associated BRAF mutant mouse models.

Kang M* , Choi J, Han J, Araki T, Kim SW, Ryu HH, Kim MG, Kim S, Jang H, Kim SY, Hwang KD, Kim S, Yoo M, Lee J, Kim K, Park P, Choi JE, Han DH, Kim Y, Kim J, Chang S, Kaang BK, Ko JM, Cheon KA, An JY, Kim SJ, Park H, Neel BG, Kim CH, Lee YS* 

J Clin Invest. 2025 Feb 18 

TNF-α-NF-κB activation through pathological α-Synuclein disrupts the BBB and exacerbates axonopathy. 

Jeon MT, Cogill SA, Kim KS, Kim Y, Kim H, Lee CY, Kim S, Son S, Kim J, Lee J, Park I, Cheon M, Kim DG*

Cell Reports. 2025 Jul 22 18 

Central Role of Hypothalamic Circuits for Acupuncture's Anti-Parkinsonian Effects. 

Oh JY, Lee H, Jang SY, Kim H, Park G, Serikov A, Jang JH, Kim J, Yang S, Sa M, Lee SE, Han YE, Hwang TY, Jung SJ, Kim HY, Lee SE, Oh SJ, Kim J, Kim J, Kim J, McHugh TJ, Lee CJ, Nam MH*, Park HJ*. 

Advanced Science. 2024 Nov 

ARNT2 controls prefrontal somatostatin interneurons mediating affective empathy.

Choi J, Jung S, Kim J, So D, Kim A, Kim S, Choi S, Yoo E, Kim JY, Jang YC, Lee H, Kim J, Shin HS, Chae S, Keum S*. 

Cell Reports. 2024 Sep 24 

The mineralocorticoid receptor and extra-synaptic NMDA receptor in the lateral habenula involve in the vulnerability to early life stressin the maternal separation model.

Miseon Kang*, Jun-mo Chung, Jihyun Noh* , Jeongyeon Kim*

Neurobiology of Stress. 2023 Sep 18 

A Review on the Use of Gold Nanoparticles in Cancer Treatment. 

Sultana R, Yadav D, Puranik N, Chavda V, Kim J, Song M. *

Anticancer Agents Med Chem. 2023 Oct 11. 

General-purpose ultrasound neuromodulation system for chronic, closed-loop preclinical studies in freely behaving rodents.

Yehhyun Jo, Sang-Mok Lee, Taesub Jung, Gijae Park, Chanhee Lee, Geun Ho Im, Seongju Lee, Jin Soo Park, Chaerin Oh, Geon Kook, Hyunggug Kim, Seongyeon Kim, Byung Chul Lee, Greg S.B. Suh, Seong-Gi Kim, Jeongyeon Kim*, Hyunjoo J. Lee*  

Advanced Science.  2022 Oct 19.  Read PDF »

Transcranial focused ultrasound stimulation with high spatial resolution.

Seongyeon Kim*, Yehhyun Jo*, GeonKook, Cristina Pasquinelli, Hyunggug Kim, Kipom Kim, Hyang-sook Hoe,Youngshik Choe, Hyewhon Rhim, Axel Thielscher,  Jeongyeon Kim*, Hyunjoo Jenny Lee*

Brain Stimulation.  2021 Jan 15.   Read PDF »

The Aftermath: Post-pandemic Psychiatric Implications of the COVID-19 Pandemic, a South Korean Perspective

Min Sooyeon, Jeong Yun Ha, Kim Jeongyeon, Koo Ja Wook*, Ahn Yong Min*

Front. Psychiatry.  2021 Oct 21.   Read PDF »

Oxytocin-induced anxiogenic behavior in juvenile male rats

Minji Jang, Taesub Jung, Miseon Kang, Jeongyeon Kim & Jihyun Noh

Animal Cells and Systems.  2021 Oct 31.   Read PDF »

A role of anterior cingulate cortex in the emergence of worker-parasite relationship

Soyoun Ahn , Yujeong Kang , Jong Won Lee , Se Jin Jeong , Yoo Jin Lee , Soomin Lee , Jeongyeon Kim , Ja Wook Koo , Jeansok J Kim , Min Whan Jung

Proc Natl Acad Sci U S A. 2021 Nov 30.    Read PDF »

Aberrant Tonic Inhibition of Dopaminergic Neuronal Activity Causes Motor Symptoms in Animal Models of Parkinson's Disease.

Heo JY*, Nam MH*, Yoon HH*, Kim J*, Hwang YJ*, Won W, Woo DH, Lee JA, Park HJ, Jo S, Lee MJ, Kim S, Shim JE, Jang DP, Kim KI, Huh SH, Jeong JY, Kowall NW, Lee J, Im H, Park JH, Jang BK, Park KD, Lee HJ, Shin H, Cho IJ, Hwang EM, Kim Y, Kim HY, Oh SJ, Lee SE, Paek SH, Yoon JH, Jin BK, Kweon GR, Shim I, Hwang O, Ryu H, Jeon S, Lee CJ.

Current Biology.  2020 Jan 20.   Read PDF »

GSK-3β activation is required for ZIP-induced disruption of learned fear.

Song S, Kim J, Park K, Lee J, Park S, Lee S, Kim J, Hong I, Song B, Choi S. 

Scientific Reports. 2020 Oct 26.

Nonmuscle myosin IIB regulates Parkin-mediated mitophagy associated with amyotrophic lateral sclerosis-linked TDP-43. 

Jun MH, Jang JW, Jeon P, Lee SK, Lee SH, Choi HE, Lee YK, Choi H, Park SW, Kim J, Jang DJ, Lee JA.  

Cell Death Dis. 2020 Nov 5. 

The novel DYRK1A inhibitor KVN93 regulates cognitive function, amyloid-beta pathology, and neuroinflammation.

Lee HJ, Woo H, Lee HE, Jeon H, Ryu KY, Nam JH, Jeon SG, Park H, Lee JS, Han KM, Lee SM, Kim J, Kang RJ, Lee YH, Kim JI, Hoe HS.

Free Radic Biol Med.  2020 Nov 20.    Read PDF »

Deletion of PLCγ1 in GABAergic neurons increases seizure susceptibility in aged mice.

Kim HY, Yang YR, Hwang H, Lee HE, Jang HJ, Kim J, Yang E, Kim H, Rhim H, Suh PG, Kim JI.

Scientific Reports.  2019 Nov 20.   Read PDF »

Multifunctional multi-shank neural probe for investigating and modulating long-range neural circuits in vivo.

Shin H, Son Y, Chae U, Kim J, Choi N, Lee HJ, Woo J, Cho Y, Yang SH, Lee CJ, Cho IJ.

Nature Communications.  2019 Aug 22.   Read PDF »

ALWPs Improve Cognitive Function and Regulate Aβ Plaque and Tau Hyperphosphorylation in a Mouse Model of Alzheimer's Disease.

Nam Y, Joo B, Lee JY, Han KM, Ryu KY, Koh YH, Kim J, Koo JW, We YM, Hoe HS.

Frontiers in Molecular Neuroscience.   2019 Aug 16.    Read PDF »

Newly developed reversible MAO-B inhibitor circumvents the shortcomings of irreversible inhibitors in Alzheimer’s disease.

Park JH, Ju YH, Choi JW, Song HJ, Jang BK, Woo J, Chun H, Kim HJ, Shin SJ, Yarishkin O, Jo S, Park M, Yeon SK, Kim S, Kim J, Nam MH, Londhe AM, Kim J, Cho SJ, Cho S, Lee C, Hwang SY, Kim SW, Oh SJ, Cho J, Pae AN, Lee CJ, Park KD.

Science Advances.  2019 Mar 20.   Read PDF »

Endogenous amyloid-β mediates memory forgetting in the normal brain.

Lee S*, Kim J*, Choi S.

Biochemical and Biophysical Research Communications.  2018 Nov 30.   Read PDF »

The small molecule CA140 inhibits the neuroinflammatory response in wild-type mice and a mouse model of AD.

Lee JY, Nam JH, Nam Y, Nam HY, Yoon G, Ko E, Kim SB, Bautista MR, Capule CC, Koyanagi T, Leriche G, Choi HG, Yang J, Kim J*, Hoe HS*.

The Journal of Neuroinflammation.  2018 Oct 11.   Read PDF » 

An Aqueous Extract of Herbal Medicine ALWPs Enhances Cognitive Performance and Inhibits LPS-Induced Neuroinflammation via FAK/NF-κB Signaling Pathways.

Lee JY, Joo B, Nam JH, Nam HY, Lee W, Nam Y, Seo Y, Kang HJ, Cho HJ, Jang YP, Kim J, We YM, Koo JW, Hoe HS.

Frontiers in Aging Neuroscience.  2018 Sep 26.   Read PDF »

Ibrutinib suppresses LPS-induced neuroinflammatory responses in BV2 microglial cells and wild-type mice.

Nam HY, Nam JH, Yoon G, Lee JY, Nam Y, Kang HJ, Cho HJ, Kim J, Hoe HS.

The Journal of Neuroinflammation.  2018 Sep 19.   Read PDF »

Control of motor coordination by astrocytic tonic GABA release through modulation of excitation/inhibition balance in cerebellum.

Woo J, Min JO, Kang DS, Kim YS, Jung GH, Park HJ, Kim S, An H, Kwon J, Kim J, Shim I, Kim HG, Lee CJ, Yoon BE.

PNAS.  2018 May 8.   Read PDF »

Ultra-sensitive detection of brain-derived neurotrophic factor (BDNF) in the brain of freely moving mice using an interdigitated microelectrode (IME) biosensor. 

Yong Kyoung Yoo, Jaekwang Lee, Jinsik Kim, Gangeun Kim, Sunpil Kim, Jeongyeon Kim, Heejung Chun, Jeong Hoon Lee, C. Justin Lee and Kyo Seon Hwang.

Scientific Reports.  2016 Sep 19.   Read PDF »

In vivo optical modulation of neural signals using monolithically integrated two-dimensional neural probe arrays. 

Yoojin Son, Hyunjoo Jenny Lee, Jeongyeon Kim, C. Justin Lee, Eui-Sung Yoon, Euisik Yoon, Kensall D. Wise, Tae Geun Kim, and Il-Joo Cho.

Scientific Reports.  2015 Oct 23.   Read PDF »

Neural probes with multi-drug delivery capability.

Hyogeun Shin, Hyunjoo Lee, Uikyu Chae, Huiyoung Kim, Jeongyeon Kim, Nakwon Choi, Jiwon Woo, Yakdol Cho, C. Justin Lee, Eui-Sung Yoon, and Il-Joo Cho.

Lab on a Chip.  2015 Jul 20.   Read PDF »

mGluR2/3 in the lateral amygdala is required for fear extinction: cortical input synapses onto the lateral amygdala as a target site of the mGluR2/3 action. 

Jihye Kim, Bobae An, Jeongyeon Kim, Sewon Park, Sungmo Park, Ingie Hong, Sukwon Lee, Kyungjoon Park, Sukwoo Choi

Neuropsychopharmacology. 2015 May 25.   Read PDF »

A multichannel neural probe with embedded microfluidic channels for simultaneous in vivo neural recording and drug delivery.

Hyunjoo J. Lee, Yoojin Son, Jeongyeon Kim, C. Justin Lee, Eui-Sung Yoon and Il-Joo Cho.

Lab on a Chip.  2015 Mar 21.   Read PDF »

Group I mGluR-dependent depotentiation in the lateral amygdala does not require the removal of calcium-permeable AMPA receptors.

Kyungjoon Park, Sukwoon Song, Ingie Hong, Beomjong Song, Jeongyeon Kim, Sungmo Park, Junuk Lee, Sangho Song, Bobae An, Jihye Kim, C Justin Lee, Ki Soon Shin, Sukwoo Choi, Sukwon Lee.

Frontiers in Behavioral Neuroscience.  2014 Aug 8.   Read PDF »

ABA renewal involves enhancements in both GluA2-lacking AMPA receptor activity and GluA1 phosphorylation in the lateral amygdala.

Park K*, Song B*, Kim J*, Hong I*, Song S*, Lee J*, Park S, Kim J, An B, Lee HW, Lee S, Kim H, Lee JC, Lee S, Choi S.

PLOS ONE.  2014 Jun 12.   Read PDF »

MONNA, a Potent and Selective Blocker for TMEM16A/Anoctamin-1. 

Oh SJ, Hwang SJ, Jung J, Yu K, Kim J, Choi JY, Hartzell HC, Roh EJ, Lee CJ.

Molecular Pharmacology.  2013 Nov 1.   Read PDF »

GluA1 phosphorylation at Serine 831 in the lateral amygdala is required for fear renewal.

Sukwon Lee*, Beomjong Song*, Jeongyeon Kim*, Kyungjoon Park, Ingie Hong, Bobae An, Sangho Song, Jiwon Lee, Sungmo Park, Jihye Kim, Dongeun Park, C. Justin Lee, Kyungjin Kim, Ki Soon Shin, Richard W. Tsien, Sukwoo Choi.

Nature Neuroscience.  2013 Aug 25.   Read PDF »

FcγRIIb mediates amyloid-β neurotoxicity and memory impairment in Alzheimer’s disease.

Tae-In Kam, Sungmin Song, Youngdae Gwon, Hyejin Park, Ji-Jing Yan, Isak Im, Ji-Woo Choi, Tae-Yong Choi, Jeongyeon Kim, Dong-Keun Song, Toshiyuki Takai, Yong-Chul Kim, Key-Sun Kim, Se-Young Choi, Sukwoo Choi, William L. Klein, Junying Yuan and Yong-Keun Jung.

Journal of Clinical Investigation.  2013 Jun 10.   Read PDF »

AMPA receptor exchange underlies transient memory destabilization on retrieval.

Hong I*, Kim J*, Kim J*, Lee S, Ko HG, Nader K, Kaang BK, Tsien RW, Choi S.

PNAS.  2013 May 14.   Read PDF »

Quantitative Proteomic Analysis of the Hippocampus in the 5XFAD Mouse Model at Early Stages of Alzheimer's Disease Pathology.

Hong I, Kang T, Yoo Y, Park R, Lee J, Lee S, Kim J, Song B, Kim SY, Moon M, Yun KN, Kim JY, Mook-Jung I, Park YM, Choi S.

Journal of Alzheimer's Disease.  2013 Mar 18.   Read PDF »

Quantitative proteomics of auditory fear conditioning.

Hong I, Kang T, Yun KN, Yoo Y, Park S, Kim J, An B, Song S, Lee S, Kim J, Song B, Kwon KH, Kim JY, Park YM, Choi S.

Biochemical and Biophysical Research Communications.  2013 Apr 26.   Read PDF »

Ex vivo depotentiation of conditioning-induced potentiation at thalamic input synapses onto the lateral amygdala requires GluN2B-containing NMDA receptors.

Sungmo Park, Sukwon Lee, Jeongyeon Kim*, Sukwoo Choi*.

Neuroscience Letters.  2012 Nov 21.   Read PDF »

Fear conditioning occludes late-phase long-term potentiation at thalamic input synapses onto the lateral amygdala in rat brain slices.

Hong I, Kim J, Song B, Park K, Shin K, Eom KD, Han PL, Lee S, Choi S.

Neuroscience Letters.  2012 Jan 6.   Read PDF »

Impairment of fear memory consolidation in maternally stressed male mice offspring: Evidence for nongenomic glucocorticoid action on the amygdala.

Eun Jeong Lee, Gi Hoon Son, Sooyoung Chung, Sukwon Lee, Jeongyeon Kim, Sukwoo Choi, Kyungjin Kim.

Journal of Neuroscience.  2011 May 11.   Read PDF »

Reversible plasticity of fear memory-encoding amygdala synaptic circuits even after fear memory consolidation. 

Hong I, Kim J, Lee J, Park S, Song B, Kim J, An B, Park K, Lee HW, Lee S, Kim H, Park SH, Eom KD, Lee S, Choi S.

Plos One. 2011 Sep 19.   Read PDF »

In vitro synaptic reconsolidation in amygdala slices prepared from rat brains.

Sukwon Lee, Jeongyeon Kim, Sukwoo Choi.

Biochemical and Biophysical Research Communications.  2011 Apr 8.   Read PDF »

Modulation of fear memory by retrieval and extinction: A clue for memory deconsolidation.

Ingie Hong*, Jeongyeon Kim*, Sukwon Lee, Beomjong Song, Sungmo Park, Junuk Lee, Jihye Kim, Bobae An, Sukwoo Choi.

Reviews in the Neurosciences.  2011 Apr 12.   Read PDF »

Reactivation of fear memory renders consolidated amygdala synapses labile.

Jeongyeon Kim*, Beomjong Song*, Ingie Hong, Junuk Lee, Jaeyong Eom, C. Justin Lee, Sukwon Lee, Sukwoo Choi.

Journal of Neuroscience.  2010 Jul 14.   Read PDF »

Extinction of cued fear memory involves a distinct form of depotentiation at cortical input synapses onto the lateral amygdala.

Ingie Hong, Beomjong Song, Sukwon Lee, Jihye Kim,Jeongyeon Kim, Sukwoo Choi.

European Journal of Neuroscience.  2009 Dec 3.   Read PDF »

Amygdala depotentiation ex vivo requires mitogen-acctivated protein kinases and protein synthesis.

Park S, Kim J, Lee S, Choi S.

Neuroreport.  2009 Mar 25.   Read PDF »

Amygdala depotentiation and fear extinction.

Kim J*, Lee S*, Park K*, Hong I8, Song B*, Son G, Park H, Kim WR, Park E, Choe HK, Kim H, Lee C, Sun W, Kim K, Shin KS, Choi S.

PNAS.  2007 Dec 26.   Read PDF »

Blockade of amygdala metabotropic glutamate receptor subtype 1 impairs fear extinction. 

Kim J,* Lee S*, Park H, Song B, Hong I, Geum D, Shin K, Choi S.

Biochemical and Biophysical Research Communications.  2007 Mar 30.   Read PDF »

Long-lasting facilitation by dehydroevodiamine. HClof synaptic responses evoked in the CA1 region of rat hippocampal slices. 

Park EJ, Suh YH, Kim J, Choi S, Lee CJ.

Neuroreport.  2003 Mar 3.   Read PDF »

Modulation of amygdala synaptic transmission by metabotropic glutamate receptors.

Kim J,  Park EJ, Chang DJ, Choi S.

The Korean Journal of Physiology and Pharmacology.  2013 Dec 21.   Read PDF »