Laboratory of Human Metabolic Diseases

Discover histologic and molecular changes
in human obesity and diabetes

Adipose tissue

Identification of fibro-inflammation and senescence related genes by scRNAseq in human visceral adipose tissue
Quantification of individual patient fibrosis through histological evaluation system (FAT scoring)

Establishment of a Korean patient-specific cohort from Obesity, Type 2 diabetes, and normal human visceral adipose tissue with large scale human transcriptomic data
Detailed observation of adipose tissue total RNAseq with fractionated adipocyte and SVF
High resolution Spatial transcriptomics & proteomics

Long non-coding RNA (lncRNA)
1. 1. Exploring the deeper function of lncRNA in human metabolic disease stage development
  2. Investigate the anonymous lncRNA and their paired proteins or downstream target axis
eQTL
1. 1. Integrate WGS with bulk/snRNA-seq from a Korean visceral adipose tissue cohort to map cis/trans eQTLs and link lncRNAs to obesity/type 2 diabetes phenotypes
  2. Conduct GWAS colocalization and fine-mapping for obesity and type 2 diabetes to prioritize causal regulatory variants and target genes

Discover pathophysiology of GDM &
unveil the mechanism of adverse pregnancy outcomes

Analyze maternal cord blood and adipose tissue to assess fetal-impact pathways and early metabolic programming
Identify markers linking maternal glycemic status to neonatal outcomes and long-term risk

Profile vascular–immune dysregulation and endothelial dysfunction
Prioritize pathways and biomarkers for risk stratification and therapeutic targeting

Prolactin physiology
1. 1. Building on previous studies, conduct cross-tissue investigations (adipose, liver, pancreas) of PRL/PRLR signaling in metabolic regulation
  2. Map the downstream axes and relate prolactin activity to glucose–lipid homeostasis across gestation and postpartum

Investigate the etiology of type 2 diabetes & metabolic diseases

Identify changes in metabolically-diseased samples, in specific cell types with spatial information

Validate key targets and pathways using human samples, mouse models, and in vitro culture system

Screening the inhibitory effect of synthetic or extraction compound on target molecule in vitro - ASC52telo-human adipose tissue derived stem cell.
Evaluating the inhibitory effect of synthetic or extraction compound on target molecule for obesity/T2D induced fibro-inflammation induced fibrosis therapy

Funding

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