Systems Physiology Lab.

Constructing predictive models of cellular states using generative AI and large-scale omics data.

• Single-cell Foundation Model

• Multi-omics Integration

• Perturbation Biology

• Network Control Theory

Dissecting spatiotemporal evolution of cancer drug resistance  and microenvironmental interactions.

• Spatial Transcriptomics

• Combinatorial Immunotherapy

• Acquired Resistance

• Tumor-Immune Microenvironment

Uncovering master regulators and mechanism-driven therapeutics for complex diseases.

• Sarcopenia & Muscle Atrophy

• Neurodegenerative Disease
  (Alzheimer's & Parkinson's disease)

• Aging & Regeneration

Molecular signature-guided drug discovery and repositioning by predicting mechanism of action (MoA).

• Drug Repositioning

• Natural Product / Herbal Medicine

• Pharmacotranscriptomics

• Docking Simulation & Molecular Dynamics